A system for treating uterine tissue having a seal assembly configured for positioning in a patient's cervical canal and uterine cavity; an expandable distal balloon portion; an expandable elongate medial balloon portion configured for movement between a first transversely expanded shape for engaging a cervical canal and a second transversely non-expanded shape for trans-cervical insertion; and a fluid source in communication with distal balloon portion and medial balloon portion for expansion of said balloon portions.

Methods for treating a patient using therapeutic renal neuromodulation and associated devices, systems, and methods are disclosed herein. One aspect of the present technology is directed to biomarker sampling in the context of neuromodulation devices, systems, and methods. Some embodiments, for example, are directed to catheters, catheter systems, and methods for sampling biomarkers that change in response to neuromodulation. A system can include, for example, an elongated shaft and a neuromodulation and sampling assembly having a neuromodulation and a sampling element.

Embodiments described herein relate to methods, systems, and devices that are used in the radio frequency ablation of tissues in a medical treatment. Probe tips may include an expandable balloon or basket with an active RF treatment area localized on a particular portion of the expandable balloon or basket. The broad or localized active treatment region on the balloon or basket allows a medical practitioner to more completely provide treatment to a region of target tissue, a volume within a tissue such as a bone, or a surface of a tissue such as a bone. Probe tips may also use magnetic materials which reduce the risk of injuring surrounding tissues adjacent to tissues under treatment.

Neuromodulation cryotherapeutic devices and associated systems and methods are disclosed herein. A cryotherapeutic device configured in accordance with a particular embodiment of the present technology can include an elongated shaft having distal portion and a supply lumen along at least a portion of the shaft. The shaft can be configured to locate the distal portion intravascularly at a treatment site proximate a renal artery or renal ostium. The supply lumen can be configured to receive a liquid refrigerant. The cryotherapeutic device can further include a cooling assembly at the distal portion of the shaft. The cooling assembly can include an applicator in fluid communication with the supply lumen and configured to deliver cryotherapeutic cooling to nerves proximate the target site when the cooling assembly is in a deployed state.

A device for delivering energy and/or measuring electrical activity in a tubular part of a body has a catheter and/or an inflatable balloon and at least one electrode. A distal end of the catheter with the at least one electrode, or the at least one electrode, is disposed on the outside of an envelope of the balloon. So as to achieve good contact between the at least one electrode and the wall of the vessel to be treated and continuous blood flow, the elasticity of the envelope of the balloon is less in at least one first region than in a second region that different from the first region. The distal end of the catheter with the at least one electrode is disposed in the at least one first region, or the at least one electrode is disposed in the at least one second region of the balloon.

A catheter for intraluminal lithotripsy including an outer wall, at least one balloon extending from the outer wall, the balloon having a first portion, a second portion proximal of the first portion and an intermediate portion between the first and second portions such that a transverse dimension of the intermediate portion is less than a transverse dimension of the first and second portions. The catheter includes a first lumen, at least one energy emitter mounted on the balloon for emitting energy to break down or soften calcium and a connector connecting the at least one energy emitter to an external energy source, the connector extending through the catheter.

A catheter for intravascular lithotripsy including an outer wall, at least one torus balloon mounted on the outer wall, a first lumen extending therein, and at least one energy emitter for emitting energy to break down calcium. The at least one energy emitter is mounted on the balloon and a connector connects the energy emitter to an external energy source, the connector extending through the catheter. The balloon has a passageway for blood flow therethrough.

A medical device that includes an expandable member, a fluid lumen, and a heating element. The expandable member has an inner expandable member and an outer expandable member. The fluid lumen is between the inner expandable member and the outer expandable member. The heating element is located inside of the fluid lumen.

A method for ablating a uterine endometrium enlarges an expandable-contractible frame to expand a compliant energy-delivery surface into a planar triangular shape and engage the surface against the walls of a patient's uterine cavity. The frame has flexible outer elements in lateral contact with the compliant surface and flexible inner elements not in said lateral contact, wherein the inner flexible element and outer flexible elements have substantially dissimilar material properties. Energy is applied through the compliant energy-delivery surface to ablate the endometrium.

An interatrial shunt device includes an opening main body. The opening main body includes an opening component for penetrating the atrial septum and expanding the atrial septal tissue to form an opening. An ablation mechanism that may damage the tissue activity at the opening of the atrial septum is disposed where the opening component contacts the atrial septal tissue. An interatrial shunt system includes the interatrial shunt device, a control mechanism of the interatrial shunt device, and an ablation power source.