A system for inflating a cryogenic ablation catheter balloon, the system comprising a fluid source containing a fluid in a liquid state, a first supply line fluidly coupled to the fluid source and configured to be fluidly coupled to an internal space within the cryogenic ablation catheter balloon, the first supply line including an inline multi-stage pressure regulating system. The multi-stage pressure regulating system includes a first stage configured to cause the fluid to transition from the liquid state to a gas state, and a second stage downstream of the first stage configured to maintain the fluid downstream of the second stage at a pressure corresponding to an inflation pressure of cryogenic ablation catheter balloon.

Systems, devices, and methods for electroporation ablation therapy are disclosed, with a protection device for isolating electronic circuitry, devices, and/or other components from a set of electrodes during a cardiac ablation procedure. A system can include a first set of electrodes disposable near cardiac tissue of a heart and a second set of electrodes disposable in contact with patient anatomy. The system can further include a signal generator configured to generate a pulse waveform, where the signal generator coupled to the first set of electrodes and configured to repeatedly deliver the pulse waveform to the first set of electrodes. The system can further include a protection device configured to selectively couple and decouple an electronic device to the second set of electrodes.

A catheter including an elongated shaft having a distal end and a proximal end, where the catheter includes a thermal element at the distal end thereof. The thermal element may be used in an ablation procedure or other procedure to heat a tissue adjacent a vessel. In some instances, the thermal element may be positioned in a first vessel and may operate to heat tissue adjacent a second vessel or adjacent an ostium between the first vessel and the second vessel. Further, the catheter may include an expandable portion on which the thermal element may be connected or positioned. The expandable portion(s) may comprise a basket or cage, a balloon, a memory shape and formable portion, and/or to other mechanical expanders.

Systems and methods for monitoring return patch impedances are provided. A tissue therapy system includes a catheter comprising at least one electrode, the catheter implantable in a patient, a first return patch electrode configured to be applied to skin of the patient, a second return patch electrode configured to be applied to the skin of the patient, and an impedance measuring circuit lectrically coupled to the at least one catheter electrode, the first return patch electrode, and the second return patch electrode. The impedance measuring circuit is configured to drive currents between the at least one catheter electrode, the first return patch electrode, and the second return patch electrode, detect, using a voltage at the at least one catheter electrode as a reference voltage, voltages generated in response to the driven currents, and measure impedances based on the driven currents and the detected voltages.

Devices and systems for the selective positioning of an intravascular neuromodulation device are disclosed herein. Such systems can include, for example, an elongated shaft and a therapeutic assembly carried by a distal portion of the elongated shaft. The therapeutic assembly is configured for delivery within a blood vessel. The therapeutic assembly can include a pre-formed shape and can be transformable between a substantially straight delivery configuration; and a treatment configuration having the pre-formed helical shape to position the therapeutic assembly in stable contact with a wall of the body vessel. The therapeutic assembly can also include a mechanical decoupler operably connected to the therapeutic assembly that is configured to absorb at least a portion of a force exerted on the therapeutic assembly by the shaft so that the therapeutic assembly maintains a generally stationary position relative to the target site.

It is an object of the present invention to provide a balloon-type ablation catheter that can measure the electric potential around the entire circumference of the pulmonary vein at a position near the left atrium with electrodes attached to a catheter distal end part of an electrode catheter inserted in a shaft in a state where a balloon is pressed against the area around the ostium of the pulmonary vein. The balloon-type ablation catheter of the present invention includes a catheter shaft (10) having a multi-lumen structure in which a plurality of lumens (11 to 17) are formed that include a liquid feeding lumen (13), (16) and an electrode catheter insertion lumen (12), a distal end tip (30) attached to the distal end of the catheter shaft (10), a balloon (50) attached to the distal end part of the catheter shaft (10), and a high-frequency current application electrode (70) provided in the balloon (50). A side hole (32) that communicates with the electrode catheter insertion lumen (12) and that opens on the side peripheral surface of the distal end tip (30) is formed in the distal end tip (30).

An electrophysiology catheter is disclosed having a balloon with a membrane. Electrodes may be disposed on the membrane. Each electrode may include a radiopaque marker. The markers may have different forms, e.g., alphanumeric or polygonal, to facilitate visualization of the electrodes using a bi-stable image and allow for selection of the appropriate electrodes to be energized during ablation of tissue. The inventive subject matter allows for proper orientation of electrodes on the balloon under a two-dimensional imaging system. This allows the operator or physician to determine if certain electrodes are adjacent or contiguous to the posterior surface of the left atrium and ablate such posterior surface for shorter duration or at a lower power to create an effective transmural lesion on the posterior wall of the left atrium while reducing the chances of damaging the adjacent anatomical structures.

A method is described for decreasing activity of at least one sympathetic nerve, nerve fiber or neuron innervating at least one blood vessel in the pulmonary vasculature of a patient to ameliorate pulmonary hypertension. In one embodiment, the method may involve advancing an intravascular treatment device to a target location in a target blood vessel within the pulmonary vasculature of the patient and using the treatment device to decrease activity of at least one sympathetic nerve, nerve fiber or neuron innervating the target blood vessel at or near the target location to ameliorate pulmonary hypertension.

A medical probe includes a shaft and a basket assembly. The shaft is configured for insertion into a cavity of an organ of a patient. The basket assembly, which is connected at a distal end of the shaft, includes (a) multiple electrically-conductive spines that are electrically-connected to one another so as to form a distributed electrode, and (b) a plurality of spine mounted electrodes, which are disposed along the spines and are configured to (i) sense electrical activity in the cavity, (ii) ablate and (iii) prevent the distributed electrode from indenting tissue in the cavity.

A system for use with performing a medical procedure is provided which comprises a balloon catheter and a processing device. The balloon catheter comprises a plurality of ablation electrodes configured to ablate tissue of patient anatomy, a stem electrode and an edge electrode. The processing device comprises a processor configured to acquire first impedance measurements between each of the ablation electrodes of the balloon catheter and an edge electrode of the balloon catheter, acquire second impedance measurements between each of the ablation electrodes of the balloon catheter and a stem electrode of the balloon catheter, determine, during ablation of the tissue, changes to at least one of the first and second impedance measurements, and indicating lesion formation based on the changes to at least one of the first and second impedance measurements.