Devices for therapeutic nasal neuromodulation and associated systems and methods are disclosed herein. A system for therapeutic neuromodulation in a nasal region configured in accordance with embodiments of the present technology can include, for example, a shaft and a therapeutic element at a distal portion of the shaft. The shaft can locate the distal portion intraluminally at a target site inferior to a patient's sphenopalatine foramen. The therapeutic element can include an energy delivery element configured to therapeutically modulate postganglionic parasympathetic nerves at microforamina of a palatine bone of the human patient for the treatment of rhinitis or other indications. In other embodiments, the therapeutic element can be configured to therapeutically modulate nerves that innervate the frontal, ethmoidal, sphenoidal, and maxillary sinuses for the treatment of chronic sinusitis.

Devices for therapeutic nasal neuromodulation and associated systems and methods are disclosed herein. A system for therapeutic neuromodulation in a nasal region configured in accordance with embodiments of the present technology can include, for example, a shaft and a therapeutic element at a distal portion of the shaft. The shaft can locate the distal portion intraluminally at a target site inferior to a patient's sphenopalatine foramen. The therapeutic element can include an energy delivery element configured to therapeutically modulate postganglionic parasympathetic nerves at microforamina of a palatine bone of the human patient for the treatment of rhinitis or other indications. In other embodiments, the therapeutic element can be configured to therapeutically modulate nerves that innervate the frontal, ethmoidal, sphenoidal, and maxillary sinuses for the treatment of chronic sinusitis.

Devices for therapeutic nasal neuromodulation and associated systems and methods are disclosed herein. A system for therapeutic neuromodulation in a nasal region configured in accordance with embodiments of the present technology can include, for example, a shaft and a therapeutic element at a distal portion of the shaft. The shaft can locate the distal portion intraluminally at a target site inferior to a patient's sphenopalatine foramen. The therapeutic element can include an energy delivery element configured to therapeutically modulate postganglionic parasympathetic nerves at microforamina of a palatine bone of the human patient for the treatment of rhinitis or other indications. In other embodiments, the therapeutic element can be configured to therapeutically modulate nerves that innervate the frontal, ethmoidal, sphenoidal, and maxillary sinuses for the treatment of chronic sinusitis.

Wearable heat transfer devices and associated systems and methods are disclosed herein. In some embodiments, a representative heat transfer device can comprise (i) a thermoelectric component (TEC) including a first side configured to be operated at a desired temperature and a second side opposite the first side, (ii) a thermally conductive contact member thermally coupled to the TEC, and (iii) a heat transfer system configured to distribute heat from the TEC. The heat transfer system includes a heat transfer structure thermally coupled to the TEC, and a heat exchanger thermally coupled to the heat transfer structure.

A device for effecting change in tissue at a treatment site includes a housing having an aperture for receiving a user's finger, a cold plate supported by said housing for cooling the tissue at the treatment site, and at least one thermoelectric cooling semiconductor thermally coupled to said cold plate and electrically coupled to a power source. In another embodiment, the cold plate may include a surface for contacting the treatment site, and at least a portion of said cold plate including said surface may extend from said housing.

Cryocatheter including an elongated flexible catheter member having a short rigid catheter tip for introduction into a therapy site and a heat exchange arrangement for freezing the catheter tip to a cryo-temperature from between about 15 C. to about 30 C. for freezing human tissue at the therapy site. Cerebral medical procedures include inter alia employing a local ice ball for sealing a bleeding rupture in an arterial wall in the case of a stroke hemorrhage, employing a local ice ball for mapping electrical disorder foci in a brain, for example, epileptic foci, and the like.

Disclosed are methods for dermatological treatment that in some embodiments include contacting a plurality of cooling probes with an area of skin and maintaining the plurality of cooling probes in contact with the area of skin for a period of time while the distal ends of the plurality of cooling probes substantially cool a volume of tissue, thereby causing a beneficial effect as a result of the substantial cooling of the volume of tissue, as well as devices useful for implementing the method.

Apparatus for applying thermotherapy to a part of the human or animal body comprising an applicator having a flexible enclosure in which thermal energy transfer fluid can circulate, a connector for connecting the applicator to a control system, an interface layer for providing a thermally conductive interface between the flexible enclosure and a treatment site and, an electrically conductive supporting layer for supporting the interface layer and capable of being energized by an electrical signal from the control system to improve the thermal conductivity of the interface layer. The apparatus also includes a valve unit for connecting the applicator to a control system, a heat exchanger for cooling a thermal energy transfer fluid and a control system for controlling the application of thermotherapy. The apparatus permits manipulation and control of the molecules of the interface layer and a thermal energy transfer fluid to improve the thermal energy transfer efficiency between the applicator and a treatment site.

A probe for performing an ablation treatment includes a shell defining an outer surface and a cryogen supply conduit positioned in the shell. The probe also includes a flexible circuit positioned on at least a portion of the outer surface of the shell. The flexible circuit includes at least one radio frequency (RF) emitter for delivering RF energy to a target tissue.