A cryoprobe having a head to which cryofluid is supplied via a capillary tube. A hose serves for removal of the cryofluid, wherein the capillary tube extends through the lumen thereof. The capillary tube comprises a flexible section that is bridged by a pull element. In this manner a cryoprobe that can be handled well is obtained that can be easily and very largely bent and still transmits tensile forces for sample extraction.

Exhaust removal apparatus and methods for cryogenic treatment are described herein. The apparatus may generally include a housing having an inlet for fluidly coupling to a source of water and an outlet for fluidly coupling to a drain, and a suction chamber in fluid communication with the housing, wherein the suction chamber is further configured to be detachably coupled to an exhaust collection reservoir having a volume of exhaust gas. Introduction of water through the inlet generates a pressure reduction within the suction chamber such that the volume of exhaust gas is drawn from the exhaust collection reservoir and into the housing for dissolving into the water and out through the drain.

A method for cryogenically treating tissue. A connection is detected between a probe having a disposable secure processor (DSP) to a handpiece having a master control unit (MCU) and a handpiece secure processor (HSP), the probe having at least one cryogenic treatment applicator. The probe is fluidly coupled to a closed coolant supply system within the handpiece via the connection. An authentication process is initiated between the DSP and the HSP using the MCU. As a result of the authentication process, one of at least two predetermined results is determined, the at least two predetermined results being that the probe is authorized and non-authorized.

In some embodiments, devices, systems, and methods for cryogenic biopsy sampling are provided. In some embodiments, a device for cryogenic biopsy sampling is provided, the device including: a dual lumen tube; an elongated probe tip coupled to the distal end of the dual lumen tube, with a first lumen extending into a hollow portion in the tip and a second lumen in fluid communication with the hollow portion; a first port in fluid communication with the first lumen; a second port in fluid communication with the second lumen, wherein the first lumen, the elongated probe element, and the second lumen provide a closed pathway through which a substance introduced through the first port can flow through the first lumen into the elongated probe element, and out of the elongated probe element through the second lumen to the second port.

Apparatus and methods for regulating cryogenic treatments are disclosed which comprise devices and methods for delivering controlled treatment of a cryoablative agent. In one variation, such devices may generally comprise an elongate probe having a distal tip and a flexible length, at least one infusion lumen positioned through or along the elongate probe, wherein the infusion lumen defines one or more openings along its length, and a liner expandably enclosing the probe. An inflow reservoir or canister valve may be fluidly coupled with a reservoir or canister containing the cryoablative agent and a modulation control unit may also be fluidly coupled with the inflow reservoir or canister valve and in fluid communication with the at least one infusion lumen. Additionally, a warming element may also be thermally coupled with the reservoir or canister.

Catheters, systems, and methods for cryogenic ablation of gastrointestinal tract tissue are described. Catheter includes a probe and a cryogenic supply assembly housed within the probe. The cryogenic supply assembly includes a sprayer orifice assembly having a sprayer tube and a seal chamber component, and a cryogenic supply line within the sprayer orifice assembly. The sprayer tube includes one or more sprayer orifices for delivery of a cryogenic fluid from the cryogenic supply line to the probe. The seal chamber component includes a seal chamber associated with each of the one or more sprayer orifices and forms a fluidic conduit between the cryogenic supply line and the one or more sprayer orifices through which the cryogenic fluid flows to the probe. The cryogenic supply assembly is configured so that the cryogenic supply line and the sprayer tube move either axially independent of one another or axially together as one unit.

A method for cryogenically treating tissue. A connection is detected between a probe having a disposable secure processor (DSP) to a handpiece having a master control unit (MCU) and a handpiece secure processor (HSP), the probe having at least one cryogenic treatment applicator. The probe is fluidly coupled to a closed coolant supply system within the handpiece via the connection. An authentication process is initiated between the DSP and the HSP using the MCU. As a result of the authentication process, one of at least two predetermined results is determined, the at least two predetermined results being that the probe is authorized and non-authorized.