A method for real-time and in-vivo detecting cancerous status of a suspected mass to in a living body. The method includes putting two electrodes of an electrical probe in contact with the suspected mass, recording an electrical impedance spectroscopy (EIS) from the suspected mass utilizing an impedance analyzer device connected to the electrical probe by plotting an impedance phase diagram respective to a swept range of frequencies while applying an alternating current (AC) voltage between the two electrodes, calculating an impedance phase slope (IPS) of the plotted impedance phase diagram in a frequency range between 100 kHz and 500 kHz, and detecting cancerous status of the suspected mass based on the calculated IPS. Detecting cancerous status of the suspected mass based on the calculated IPS includes detecting the suspected mass is a cancerous mass or a precancerous mass if the calculated IPS is less than a reference IPS.

An electrosurgical generator includes a first radio frequency source having a first power supply configured to output a first direct current waveform; a first radio frequency inverter coupled to the first power supply and configured to generate a first interrogation waveform and a first radio frequency waveform from the first direct current waveform; and a first controller configured to control the first radio frequency inverter to output the first radio frequency waveform based on a response of the first interrogation waveform. The generator also includes a second radio frequency source having a second power supply configured to output a second direct current waveform; a second radio frequency inverter coupled to the second power supply and configured to generate a second interrogation waveform simultaneously as the first interrogation waveform and a second radio frequency waveform simultaneously as the first radio frequency waveform; and a second controller configured to control the second radio frequency inverter to output the second radio frequency waveform based on a response of the second interrogation waveform.

A method for identifying cancerous status of margins of a tumor. The method includes putting at least two electrodes of a bioimpedance sensor in contact with a target region of surface of a freshly dissected tumor tissue, measuring two impedimetric criteria associated with the target region, and detecting cancerous status of the target region based on the two measured impedimetric criteria. The two measured impedimetric criteria includes an electrical impedance magnitude of the target region at a frequency of 1 kHz (Z.sub.1 kHz) and an impedance phase slope (IPS) of the target region in a frequency range of 100 kHz to 500 kHz.

The disclosure relates to variable power modular electronic systems for generating unipolar and bipolar electrical pulses and associated uses thereof. In an embodiment, such a system includes one or more pulse generators for generating electrical pulses that can be connected in series; a charging circuit for charging the pulse generators; and a controller communicatively coupled to the pulse generators and the charging circuit. Advantageously, each pulse generator may include an AC/DC rectifier and a DC/AC inverter connected to said AC/DC rectifier in a bridge configuration to generate bipolar output electrical pulses or pulse trains. In addition, the charging circuit may include a DC/DC step-up converter connected to an indirect DC/AC inverter. The system provided in various embodiments of the disclosure also provides a great versatility for adaptation to various applications and high output voltage and current values.

A protection circuit for a direct-current (DC) ablation prostate therapy system. The protection circuit is selectively coupled to a power source that provides DC constant current to a plurality of electrodes in a catheter configured to deliver DC ablation therapy to prostate tissue. The protection circuit is controlled by a controller and a switching circuit to buffer energy from the power source in response to a monitoring circuit that monitors at least one parameter of the DC ablation therapy, such as voltage or impedance. The controller is configured to selectively activate the switching circuit based on the monitoring circuit detecting an undesirable increase in the energy delivered for the DC ablation therapy.

Catheter systems, tools and methods are disclosed for the selective and rapid application of DC voltage to drive irreversible electroporation, with the system controller configurable to apply voltages to an independently selected subsets of electrodes, such that voltages of one polarity are applied to a multiplicity of electrodes on a first medical device and voltages of the opposite polarity to a multiplicity of electrodes on a second medical device. The first and second medical devices can be epicardial catheters positioned such that their opposing distal tips are approximately aligned and whose segments with electrodes collectively wrap around the pulmonary veins.

The present disclosure provides electroporation systems and methods of energizing a catheter for delivering electroporation. A catheter for delivering electroporation includes a distal section and an electrode assembly. The distal section is configured to be positioned in a vein within a body. The vein defines a central axis. The electrode assembly is coupled to the distal section and includes a structure and a plurality of electrodes distributed thereabout. The structure is configured to at least partially contact the vein. Each of the electrodes is configured to be selectively energized to form a circumferential ring of energized electrodes that is concentric with the central axis of the vein.

An electrosurgical system is provided and includes a bipolar electrosurgical instrument and an electrosurgical generator. The bipolar electrosurgical instrument is arranged to seal and cut tissue captured between jaws of the bipolar electrosurgical instrument. The electrosurgical generator is arranged to supply RF energy through the bipolar electrosurgical instrument, monitor the supplied RF energy, and adjust or terminate the supplied RF energy to optimally seal the tissue.

The present disclosure provides electroporation systems, methods of controlling electroporation systems to limit electroporation arcs through intracardiac catheters, and catheters for electroporation systems. One method of controlling an electroporation system including a direct current (DC) energy source, a return electrode connected to the DC energy source, and a catheter connected to the DC energy source is disclosed. The catheter has a at least one catheter electrode. The method includes positioning the return electrode near a target location within a body and positioning the catheter electrode adjacent the target location within the body. A system impedance is determined with the return electrode positioned near the target location and the catheter electrode positioned within the body. The system impedance is adjusted to a target impedance to limit arcing from the catheter electrode.

An electrosurgical system can include an electrosurgical generator, a feedback circuit or controller, and an electrosurgical tool. The feedback circuit can provide an electrosurgery endpoint by determining the phase end point of a tissue to be treated. The electrosurgical system can include more than one electrosurgical tool for different electrosurgical operations and can include a variety of user interface features and audio/visual performance indicators. The electrosurgical system can also power conventional bipolar electrosurgical tools and direct current surgical appliances.