A system for application of neurostimulation includes an outer sheath, an elongate inner member in the outer sheath and movable relative to the outer sheath. The inner lumen has a distal end. An expandable member is coupled to the distal end of the inner member and is in the outer sheath. The expandable member is self-expanding upon from a compressed state in the outer sheath to an expanded state out of the outer sheath. The expandable member includes a distal portion including a plurality of wires woven together and a proximal portion including the plurality of wires extending parallel to a longitudinal axis. The system includes a plurality of electrode assemblies outward of the expandable member and circumferentially spaced around the expandable member. Each electrode assembly is coupled to two of the wires extending parallel to the longitudinal axis. Each electrode assembly includes a plurality of longitudinally-spaced electrodes.

An ablation procedure guidance method is provided herein. The ablation procedure guidance method is implemented by a generation engine executing on a processor. The ablation procedure guidance method includes receiving inputs including images and conduction velocity vector estimations and generating a digital twin of an anatomical structure utilizing the images and the conduction velocity vector estimations. The ablation procedure guidance method also includes presenting, via a user interface of the generation engine, the digital twin to provide precision ablation guidance of the anatomical structure and provide electrophysiology information of the anatomical structure.

An intraluminal microneurography probe has a probe body configured to be introduced into an artery near an organ of a body without preventing the flow of blood through the artery. An expandable sense electrode and an expandable stimulation electrode are fixed to the probe body at one end of each electrode such that movement of the other end toward the fixed end causes the sense electrode to expand from the probe body toward a wall of the artery. A ground electrode is configured to couple to the body, and a plurality of electrical connections are operable to electrically couple the electrodes to electrical circuitry. The sense electrode is operable to measure sympathetic nerve activity in response to excitation of the stimulation electrode. A radio frequency ablation element is located between the expandable sense electrode and expandable stimulation electrode, and is operable to ablate nerves proximate to the artery.

According to some embodiments, a medical instrument (for example, an ablation device) comprises an elongate body having a proximal end and a distal end, an energy delivery member positioned at the distal end of the elongate body, a first plurality of temperature-measurement devices carried by or positioned within the energy delivery member, the first plurality of temperature-measurement devices being thermally insulated from the energy delivery member, and a second plurality of temperature-measurement devices positioned proximal to a proximal end of the energy delivery member, the second plurality of temperature-measurement devices being thermally insulated from the energy delivery member.

A surgical instrument end effector assembly includes a first jaw member defining an insulative tissue-contacting surface and first and second electrically-conductive tissue-contacting surfaces disposed on either side of the insulative surface. A second jaw member of the end effector assembly includes an ultrasonic blade body positioned to oppose the insulative surface of the first jaw member, and first and second electrically-conductive tissue-contacting surfaces disposed on either side of the ultrasonic blade body and positioned to oppose the first and second electrically-conductive surfaces, respectively, of the first jaw member. The first jaw member is movable relative to the second jaw member between a spaced-apart position and an approximated position to grasp tissue therebetween. The first and second electrically-conductive surfaces of the second jaw member are movable, independent of the first jaw member, relative to the first jaw member and the ultrasonic blade body between a retracted position and an extended position.

Disclosed herein is an electroporation system including a catheter shaft, at least one electrode coupled to the catheter shaft at a distal end thereof, and a signal generator. The signal generator is coupled in communication with the at least one electrode. The signal generator supplies a biphasic pulse to the at least one electrode, the biphasic pulse including a first phase having a first polarity, a first initial voltage amplitude, and a first pulse width. The biphasic pulse including a second phase having a second polarity opposite to the first polarity, a second initial voltage amplitude, and a second pulse width, wherein at least one of the first initial voltage amplitude or the first pulse width is different from the second initial voltage amplitude or the second pulse width, respectively. A leading edge of the second phase occurs after an interphase delay following a trailing edge of the first phase.

The present disclosure provides catheter systems, electrode assemblies, and methods for electrically stimulating one or more points about the circumference of the renal artery to provide real time intraprocedural operational feedback to the operator of a renal denervation procedure to allow for more precise and thorough ablation of the renal artery and better patient outcomes. In many embodiments, an electrode assembly is provided that includes multiple splines that extend from an insulated proximal hub to an insulated distal hub and are interconnected to an electrical wire to allow the splines to independently function as electrical stimulation electrodes. The electrically active splines can then be energized at one or more desired points during a renal denervation procedure to provide operational feedback.

The disclosed technology includes couplers, nose pieces, and strain relief hubs for ablation catheter assemblies and methods of using the same. The disclosed technology can include a medical probe having a coupler having a first portion, a second portion, and a vent port. The second portion can slide between a first position and a second position. When in the first position, the vent port can be at least partially obstructed by the first portion and, when in the second position, the vent port can be unobstructed by the first portion. The medical probe can include a nose piece having an outer diameter of less than 0.14 inches and an aperture extending therethrough. The aperture can be sized to receive a catheter. The medical probe can include a strain relief hub having a first portion and a second portion and configured to be coupled to a handle of the medical probe.

Flexible circuit strips of a catheter balloon may comprise a substrate and a contact electrode disposed on the substrate. A cover may be disposed over a peripheral portion of the contact electrode and an adjacent portion of the substrate The cover is intended to increase robustness of the contact electrode in response to fatigue that might arise from repeated expansion and contraction of the catheter balloon.

An apparatus includes a catheter shaft assembly and an end effector. The end effector is configured to transition between a first configuration and a second configuration. The end effector is configured to fit within an outer sheath in the first configuration. The end effector is configured to expand outwardly away from the longitudinal axis in the second configuration when exposed distally relative to the distal end of the outer sheath. The end effector includes a resilient frame assembly that is configured to resiliently bias the end effector toward the second configuration. The end effector further includes a first flex circuit assembly secured to the resilient frame assembly. The first flex circuit assembly includes a first flexible substrate and a first plurality of electrodes positioned on the first flexible substrate. The electrodes are configured to pick up electrical potentials from tissue or blood or ablate tissue.