Tumor treating fields (TTFields) can be delivered by implanting a plurality of sets of implantable electrode elements within a person's body. Temperature sensors positioned to measure the temperature at the electrode elements are also implanted, along with a circuit that collects temperature measurements from the temperature sensors. In some embodiments, an AC voltage generator configured to apply an AC voltage across the plurality of sets of electrode elements is also implanted within the person's body.

A plasma treatment unit having a high-voltage stage (5, 6), arranged in a housing, for generating high-voltage signals suitable for the generation of a plasma, and having a head part (2) which is connectable to the high-voltage stage (5, 6) and in which there is situated an electrode arrangement (13) shielded by a dielectric (9), is suitable for plasma treatments in particular in the body interior by virtue of the fact that the head part (2) has an elongate transition piece (10) which is attachable to the housing and on that end of which which is not connectable to the housing there is arranged a treatment head (16, 16), the dimensions of which perpendicular to the longitudinal direction of the transition piece (10) greatly exceed the dimensions of the transition piece (10), and that, in the treatment head (16, 16), the electrode arrangement (13) forms a spatially closed flexible sheath (12) around a resiliently elastic core (14) and is covered at its outer lateral surface by a thin layer (15) of the flexible dielectric (9), such that the treatment head (16, 16) can, as it is inserted into a body interior, assume the shape of the surrounding tissue in the body interior.

One embodiment of the present application sets forth a method for predicting recurrence of cancerous cells in a patient that includes measuring, by a first subset of electrodes included in an electrode array operating at a first frequency, a first impedance of a first section of a first sample of tissue excised from the patient, computing a first Cole relaxation frequency for the first section of the first sample based on the first impedance, and generating a first prediction relating to cancerous cells in the patient based at least in part on the first Cole relaxation frequency.

An apparatus comprising: at least one electrode, having a first potential, arranged to sense a biosignal; a conductive shield provided over the at least one electrode where the conductive shield is configured to be driven to a second potential wherein the second potential is equivalent to the first potential plus a multiple of an inverted common mode voltage; and wherein the conductive shield is coupled to a drain to enable triboelectric charges to be dissipated.

Various aspects of the invention relate to methods and devices for treating diseases and conditions including atherosclerosis and endocarditis using low-temperature, non-equilibrium plasmas. A device may be, for example, a catheter that carries electrodes and a dielectric material for generating a localized, non-equilibrium plasma in a bodily fluid such as blood.

Tissue is treated using a radiofrequency power supply connected to an applicator having a chamber filled with an electrically non-conductive gas surrounded by a thin dielectric wall. A radiofrequency voltage is applied at a level sufficient to ionize the gas into a plasma and to capacitively couple the ionized plasma with the tissue to deliver radiofrequency current to ablate or otherwise treat the tissue.

A catheter tip electrode has a tissue contacting surface which electrically conducts RF energy to the tissue and is more thermally conductive than adjacent non-electrically conductive coating or cover which prevents RF conduction to the tissue contacting that surface. The tip electrode has a shell with a nonablating hollow proximal neck portion and a distal ablating portion defining a fluid chamber, and a plug-like support member which is configured with a fluid channel on its outer surface so a fluid passage is provided between the member and the neck portion for convective or direct cooling of the nonablating neck portion and nonconductive tubing covering it.

A method and system of providing therapy to a patient's uterus is provided, which can include any number of features. The method can include the steps of inserting a uterine device into the uterus and performing a uterine integrity test to determine that the uterus is intact and not perforated. If it is determined that the uterus is not perforated, a patency test can be performed to determine that the uterine device is not clogged or embedded in tissue. If the uterus is intact and the device is not clogged or embedded in tissue, the uterus can be treated with the uterine device, e.g., uterine ablation. Systems for performing these methods are also disclosed.

A device having an optical element with a conductive coating. The device may include an optical element, a conductive material and at least one connector. The conductive material is disposed on at least a portion of the optical element. The optical element, for example, may be an object lens of an endoscope or an optical coupler. The connectors (acting as terminal(s)) are capable of providing energy (such as electrical energy) to the conductive material. In one aspect, the conductive material is an optically transparent material. Advantageously, the device may allow visualization of an objectsuch as body tissue or other matterconcurrent with the application of energy to the object via the conductive coating. This allows the user to observe the alteration of tissue and other matter in real time as the energy is delivered.

The disclosure provides a method of manufacturing a flexible circuit electrode assembly and an apparatus manufactured by said method. According to the method, an electrically conductive sheet is laminated to an electrically insulative sheet. An electrode is formed on the electrically conductive sheet. An electrically insulative layer is formed on a tissue contacting surface of the electrode. The individual electrodes are separated from the laminated electrically insulative sheet and the electrically conductive sheet. In another method, a flexible circuit is vacuum formed to create a desired profile. The vacuum formed flexible circuit is trimmed. The trimmed vacuum formed flexible circuit is attached to a jaw member of a clamp jaw assembly.