An interference cancellation circuit includes finite impulse response (FIR) filter configured to set a channel impulse response (CIR) coefficient for each transmission path for a transmission signal and obtain a CIR-adapted transmission signal by applying the CIR coefficient to the transmission signal, a kernel generation circuit configured to generate an interference model based on the CIR-adapted transmission signal, an adaptive filter configured to estimate an interference signal for each reception path by estimating an interference model coefficient for the interference model and generate an interference-cancelled signal by filtering out the interference signal from a reception signal, and a CIR estimation circuit configured to estimate the CIR coefficient in a next sample period based on the interference-cancelled signal through a backpropagation method and transmit the estimated CIR coefficient to the FIR filter.