The present invention generally relates to an image-guided laser irradiation device for targeted ablation, stimulation, molecular delivery and therapy. Specifically, the invention relates to application of the device in therapies needing precise and targeted removal of a sample, or delivery of impermeable molecules for therapeutic outcome. More specifically, the invention relates to the application of the device in the therapy of visual disorders.

In one aspect of the present disclosure, a laser fiber may include an optical fiber. The optical fiber may include a proximal portion. The optical fiber also may include a distal portion having a distal end. The optical fiber may be configured to transmit laser energy from the proximal portion to the distal portion for emission of the laser energy from the distal end. The optical fiber also may include a distal tip surrounding the distal portion to protect the distal portion. The distal tip may include a sheet glass material having a laser energy emitting surface. The laser energy emitting surface may be defined by a chemically-strengthened surface layer.

In a laser beam delivery system for an ophthalmic laser system, a single multi-use beam sampler is employed to form three sampled laser beams, including two for redundant laser energy monitoring and one for laser focal point depth measurement. The beam sampler is a transparent plate with preferably parallel front and back surfaces. The front surface reflects a fraction of the incoming beam to form the first sampled beam toward an energy monitoring detector. The back surface reflects another fraction of the beam to form a second sampled beam exiting backwardly from the front surface toward another energy monitoring detector. An objective lens focuses the transmitted beam onto a target, and collects back reflected or scattered light from the target to form a return beam. The back surface of the beam sampler reflects a fraction of the return beam to form the third sampled beam toward a third detector.

An ophthalmic surgery laser system and method of laser delivery for an ophthalmic surgery laser system are disclosed herein. Embodiments of the system and method are directed to an ophthalmic surgery laser system including a laser engine, a laser guide, and a laser shaper. Embodiments of the system and method are directed to a laser delivery system for an ophthalmic surgery laser system. Embodiments of the system and method are directed to an ophthalmic surgery laser system including additional functionality such as laser scanning confocal microscopy, 3D laser scanning, and laser beam diagnostics. Embodiments further include the use of a lower power illumination source.

The present invention relates to a flexible surgical system for endoscopic spinal decompression and methods thereof. Various methods of accessing the epidural space with this instrument are described. The system design enables placement of the device through several approaches. It is then advanced under direct visualization or fluoroscopic (X-Ray), for example, into areas of the spine including lumbar (low back), thoracic (mid and upper back) and cervical (neck). The pathologies encroaching upon the spinal space can then be visualized wherein the epidural membrane can optionally be displaced to further aid in visualization. The membrane can be used to protect regions of tissue adjacent the site to tissue removal.

The presently disclosed subject matter provides techniques for inducing collagen cross-linking in human tissue, such as cartilage, by inducing ionization of the water contained in the tissue to produce free radicals that induce chemical cross-linking in the human tissue. In an embodiment, a femtosecond laser operates at sufficiently low laser pulse energy to avoid optical breakdown of the tissue being treated. In an embodiment, the femtosecond laser operates in the infrared frequency range.

A system includes a focus optic configured to converge an electromagnetic radiation (EMR) beam to a focal region located along an optical axis. The system also includes a detector configured to detect a signal radiation emanating from a predetermined location along the optical axis. The system additionally includes a controller configured to adjust a parameter of the EMR beam based in part on the signal radiation detected by the detector. The system also includes a window located a predetermined depth away from the focal region, between the focal region and the focus optic along the optical axis, wherein the window is configured to make contact with a surface of a tissue.

A surgical laser capsulorhexis system includes a laser source, configured to generate a laser cutting beam; a beam guidance system, configured to guide the laser cutting beam from the laser source; a beam focuser, configured to guide the laser cutting beam from the laser source and to generate a focused laser cutting beam, the focused laser cutting beam having a two-dimensional beam pattern; a beam coupler, configured to redirect the focused laser cutting beam; and a patient interface lens, configured to guide the redirected focused laser cutting beam to a tissue surface of a procedure eye.

The present disclosure relates to a laser irradiating apparatus including a laser resonator configured to generate a laser beam and output the laser beam forwards, a first passage part located in front of the laser resonator and configured to allow the laser beam generated from the laser resonator to pass through, and a second passage part located as being spaced from the first passage part and configured to allow the laser beam passing through the first passage part to pass through.

A laser apparatus according to the present invention may comprise: a plurality of reflection mirrors which form a resonance path so as for light to be amplified by an induced emission; a medium having a first surface which forms a vertical surface with respect to the resonance path, and a second interface which does not form a vertical surface with respect to the resonance path, and absorbs energy from a light source and amplifies and emits the light; and a saturable absorber having a second surface which forms a vertical surface with respect to the resonance path, and a second interface which does not form a vertical surface with respect to the resonance path, and generates ultrashort pulses. The laser apparatus according to the present invention has the effects of cutting a saturable absorber having a specific crystallographic axis to thereby make polarization capacity in one direction advantageous and minimize propagation loss. In addition, the laser apparatus according to the present invention has the effect of maximizing transmittivity maintenance capacity of polarization orientation in one direction by arranging a medium and a saturable medium so as to have a specific inclined plane.