The presently disclosed subject matter provides techniques for inducing collagen cross-linking in human tissue, such as cartilage or cornea, without using a photosensitizer (e.g., riboflavin), by inducing ionization of the water contained in the tissue to produce free radicals that induce chemical cross-linking in the human tissue. In an embodiment, a femtosecond laser operates at sufficiently low laser pulse energy to avoid optical breakdown of tissue. In an embodiment, the femtosecond laser operates in the infrared frequency range.

The present invention relates to a medical skin wrinkle improvement device using a peak of a laser pulse wave, and more specifically, to a medical skin wrinkle improvement device using a peak of a laser pulse wave, thereby lowering the degree of carbonization of a skin tissue having the laser irradiated thereon, thus enhancing a skin generation effect and shortening recovery time. The present invention comprises: a main body (100) which has formed on the upper part thereof a holding groove (110) having a tablet computer (200) attached/detached thereto, and which has mounted therein a controller (120) for controlling a hand piece (300) and the tablet computer (200); the hand piece (300) which comprises a laser oscillation unit (320), an optical unit (330) and a laser scanner, the laser oscillation unit (320) generating a laser to be irradiated for skin treatment, the optical unit (330) irradiating, as a parallel light, the laser generated by the laser oscillation unit (320), and the laser scanner adjusting the irradiation location of the laser transferred from the optical unit (330); and the tablet computer (200) which is provided with data input and screen display functions by means of a touch screen method, and which remotely controls the main body (100) through the transmission/reception of a bi-directional wireless signal.

The presently disclosed subject matter provides techniques for inducing collagen cross-linking in human tissue, such as cartilage or cornea, without using a photosensitizer (e.g., riboflavin), by inducing ionization of the water contained in the tissue to produce free radicals that induce chemical cross-linking in the human tissue. In an embodiment, a femtosecond laser operates at sufficiently low laser pulse energy to avoid optical breakdown of tissue. In an embodiment, the femtosecond laser operates in the infrared frequency range.

An exemplary treatment system can be provided which can include a laser system configured to emit at least one laser beam, and an optical system configured to focus the laser beam(s) to a focal region at a selected distance from a surface of a tissue. The focal region can be configured to illuminate at least a portion of a target. The optical system can cause an irradiation energy transferred to the focal region of the laser beam(s) to (i) generate a plasma in a first region of the tissue adjacent to the target, and (ii) avoid a generation of a plasma in a second region of the tissue. The optical system has a numerical aperture that is in the range of about 0.5 to about 0.9. An exemplary method can also be provided to control such treatment system.

An applicator comprising multiple laser assemblies connected to a power supply and a controller that switches each pulse to a different one of the laser assemblies. Each laser assembly deposits a laser spot on the skin and the result is to produce a large aggregate spot without requiring extra power or extra lasers. In one embodiment, each pulse serves as a trigger to switch the next pulse to the next laser assembly.

The device comprises at least a laser source (5); an optical fiber (1) with an optical radiation entrance end (1.2) and an optical radiation output end (1.1); and a coupling system (8) for coupling the laser source (5) and the optical fiber (1), adapted to inject an optical radiation emitted by the laser source (5) into the entrance end (1.2) of the optical fiber (1). The optical fiber (1) is a multi-mode optical fiber. The coupling system (8) is adapted to inject the optical radiation into the optical fiber (1) with such an inclination (a) as to reduce or eliminate the fundamental transmission mode and to promote the transmission according to at least one higher-order transmission mode The optical radiation at the output end (1.1) of the optical fiber (1) has a cone-shaped distribution (3) wherein the intensity is maximal on the peripheral volume of an emission cone and is minimal inside the emission cone.

Techniques are disclosed for delivering laser radiation to a target site in an organism. Preferably, pulsed laser radiation is delivered to the target site using a hypodermic needle. Depending on the embodiment, a focusing lens is used to focus the laser radiation into the needle shaft through which the laser light is propagated and delivered/transferred to the target site. The hypodermic needle may be a standard hypodermic needle or a modified hypodermic needle containing a lens. Various types of adapters are disclosed that attach to standard optical connectors at one end and to the standard connections of a hypodermic needle at the other end. In variations, the laser-delivery hypodermic needles of the instant design are self-contained and wirelessly controlled. The embodiments can be practiced to benefit a variety of use-cases in the medical, healthcare, life sciences and other fields.

An apparatus and method of treatment of an animal using the apparatus are disclosed. The apparatus includes a scalpel, a laser included in the scalpel, and a visible light source included in the scalpel. The visible light source provides a visible targeting beam. The method of treatment includes activating a visible targeting beam in a laser scalpel. The visible targeting beam has an illumination intensity. The method further includes illuminating a tumor that includes cancerous cells and non-cancerous cells with the visible targeting beam, activating an invisible mid-infrared laser included in the scalpel to produce a laser spot at the tumor, and ablating the cancerous cells while leaving the non-cancerous cells substantially undamaged.

A laser pulse energy control system which includes a laser source and a beam divider positioned to receive a calibration laser pulse produced by the laser source. The beam divider reflects a first portion of the calibration laser pulse along a first optical path toward a first plane and transmits a second portion of the calibration laser pulse along a second optical path toward a second plane. An energy meter determines an energy of the first portion of the calibration laser pulse at the first plane and a fluence profiler determines a fluence profile of the second portion of the calibration laser pulse at the second plane. The processor controls an energy of an ablation laser pulse produced by the laser source based on the fluence profile of the second portion of the calibration laser pulse and the energy of the first portion of the calibration laser pulse.

In one aspect of the present disclosure, a laser fiber may include an optical fiber. The optical fiber may include a proximal portion. The optical fiber also may include a distal portion having a distal end. The optical fiber may be configured to transmit laser energy from the proximal portion to the distal portion for emission of the laser energy from the distal end. The optical fiber also may include a distal tip surrounding the distal portion to protect the distal portion. The distal tip may include a sheet glass material having a laser energy emitting surface. The laser energy emitting surface may be defined by a chemically-strengthened surface layer.