An exemplary treatment system can be provided which can include a laser system configured to emit at least one laser beam, and an optical system configured to focus the laser beam(s) to a focal region at a selected distance from a surface of a tissue. The focal region can be configured to illuminate at least a portion of a target. The optical system can cause an irradiation energy transferred to the focal region of the laser beam(s) to (i) generate a plasma in a first region of the tissue adjacent to the target, and (ii) avoid a generation of a plasma in a second region of the tissue. The optical system has a numerical aperture that is in the range of about 0.5 to about 0.9. An exemplary method can also be provided to control such treatment system.

Apparatuses and methods are disclosed for applying laser energy having desired pulse characteristics, including a sufficiently short duration and/or a sufficiently high energy for the photomechanical treatment of skin pigmentations and pigmented lesions, both naturally-occurring (e.g., birthmarks), as well as artificial (e.g., tattoos). The laser energy may be generated with an apparatus having a resonator with a sub-nanosecond round trip time.

Systems, devices, and methods for identifying a target in vivo are disclosed. A target identification system for use in electrosurgery includes a probe, an optical splitter, and a spectroscopy system. The probe includes an optical pathway to pass a first optical signal to an anatomical target and at least a portion of a second optical signal from the anatomical target. The optical splitter includes a first port to direct the first optical signal to the optical pathway and to receive the at least a portion of the second optical signal from the optical pathway, a second port to receive the first optical signal, and a parabolic reflector to redirect the portion of the second optical signal. The spectroscopy system can identify a characteristic of the anatomical target based on the redirected at least a portion of the second optical signal.

An ablation instrument (e.g., an ablation balloon catheter system) includes an elongate catheter having a housing with a window formed therein. An energy emitter is coupled to the elongate catheter and is configured to deliver ablative energy. A controller is received within the window and is coupled to the energy emitter such that axial movement of the controller within the window is translated to axial movement of the energy emitter and rotation of the controller within the window is translated into rotation of the energy emitter. The instrument includes a motor that is at least partially disposed within the housing of the catheter; a first gear that is operatively connected to and driven by the motor; and a second gear that is coupled to the energy emitter and is driven by the first gear to cause rotation of the energy emitter, while allowing the energy emitter to move axially.

A tissue ablating laser device (100) comprises a laser source (110) configured to generate a base laser beam (140) and a beam shaping optics (120) configured to receive the base laser beam (140) and to transform the base laser beam (140) to an emitting laser beam (143). The beam shaping optics (120) further is configured to focus the base laser beam (140) such that the emitting laser beam (143) has a focusing angle (142) of about 10° or less.

A laser system includes a first cavity to output a laser light along a first path, a first mirror to receive the laser light from the first cavity, and redirect the laser light along a second path that is different than the first path, a beam splitter removably located at a first position on the second path, a beam combiner removably located at a second position on the second path, and an alignment device having first and second alignment features. The first and second alignment features occupy the first position and the second position, respectively, on the second path, when the beam splitter and the beam combiner are removed from the first position and the second position.

A laser system includes a laser source generating a laser beam having ultra-short pulses; a laser delivery assembly optically receiving the laser beam and comprising: a beam splitter configured to split the laser beam between a first beam delivery path and a second beam delivery path; and at least one focusing lens optically coupled to the beam splitter and configured to focus the laser beam from each of the first beam delivery path and the second beam delivery path to a focal point on a predefined plane; wherein the first beam delivery path intersects the predefined plane at a first angle, the second beam delivery path intersects the predefined plane at a second angle, and a first pulse from the first beam delivery path and a second pulse from the second beam delivery path are coincident at the focal point.

A system includes a focus optic configured to converge an electromagnetic radiation (EMR) beam to a focal region located along an optical axis. The system also includes a detector configured to detect a signal radiation emanating from a predetermined location along the optical axis. The system additionally includes a controller configured to adjust a parameter of the EMR beam based in part on the signal radiation detected by the detector. The system also includes a window located a predetermined depth away from the focal region, between the focal region and the focus optic along the optical axis, wherein the window is configured to make contact with a surface of a tissue.

Provided herein are cranial implant devices that include a cranial implant housing configured for subgaleal scalp implantation within, beneath, and/or over at least one cranial opening of a subject. The cranial implant housing comprises a substantially anatomically-compatible shape and is fabricated from one or more sonolucent materials that permit transmission of mechanical waves through the sonolucent materials when the cranial implant device is subgaleally implanted. The cranial implant housing also includes a pressure sensor operably connected to the cranial implant housing, which pressure sensor is configured to sense intracranial pressure (ICR). The cranial implant housing also includes at least a first controller operably connected to the pressure sensor, which first controller is configured to selectively effect the pressure sensor to sense the ICR within a cranium of the subject to generate ICP data and to transmit the ICP data to an ICP data receiver. In addition, the cranial implant housing also includes a power source operably connected or connectable at least to the first controller. Other aspects are directed to various related systems, computer readable media, and methods.

Apparatuses and methods are disclosed for applying laser energy having desired pulse characteristics, including a sufficiently short duration and/or a sufficiently high energy for the photomechanical treatment of skin pigmentations and pigmented lesions, both naturally-occurring (e.g., birthmarks), as well as artificial (e.g., tattoos). The laser energy may be generated with an apparatus having a resonator with a sub-nanosecond round trip time.