Systems, devices, and methods for automatic control of laser treatment of target structure in a body of a subject based on acoustic feedback in response to delivery of laser energy to the target are disclosed. An exemplary laser energy delivery system comprises a laser system to direct laser energy at a body target, and a controller circuit to receive an acoustic signal in response to delivery of laser energy to the target, and to measure acoustic properties from the acoustic signal. The control circuit may generate control signals for controlling the laser system to adjust laser energy output, or for controlling an actuator to adjust a position of a laser fiber distal end relative to the target to achieve a desired therapeutic effect.

In certain embodiments, a system for controlling a position of a focal point of a laser beam comprises a beam expander, a scanner, an objective lens, and a computer. The beam expander controls the focal point of the laser beam and includes a mirror and expander optical devices. The mirror has a surface curvature that can be adjusted to control a z-position of the focal point. The expander optical devices direct the laser beam towards the mirror and receive the laser beam reflected from the mirror. The scanner receives the laser beam from the beam expander and manipulates the laser beam to control an xy-position of the focal point. The objective lens receives the laser beam from the scanner and directs the beam towards the target. The computer receives a depth instruction, and sets actuation parameters to control the surface curvature of the mirror according to the depth instruction.

An ophthalmic surgical laser system and method for forming a lenticule in a subject's eye using “fast-scan-slow-sweep” scanning scheme. A high frequency scanner forms a fast scan line, which is placed by the XY and Z scanners at a location tangential to a parallel of latitude of the surface of the lenticule. The XY and Z scanners then move the scan line in a slow sweep trajectory along a meridian of longitude of the surface of the lenticule in one sweep. Multiple sweeps are performed along different meridians to form the entire lenticule surface, and a prism is used to change the orientation of the scan line of the high frequency scanner between successive sweeps. In each sweep, the sweeping speed along the meridian is variable, being the slowest at the edge of the lenticule and the fastest near the apex.

Systems and methods are disclosed for flexibly controlling laser pulses being output from a laser system. An example surgical system comprises a laser, a laser energy control system configured to regulate the amount of electromagnetic energy of each laser pulse that exits the laser system, and a laser pulse controller. The control signals communicated by the laser pulse controller may include a sub-carrier signal that modulates the amount of electromagnetic energy of the laser pulses that exit the laser system. The control signals may further include a threshold signal and/or a maximum power signal. The sub-carrier signal may oscillate between the threshold power and a maximum power.

A catheter system for treating site within or adjacent to a vessel wall or a heart valve includes a light source, a first and second light guide, and an optical alignment system. The light source generates light energy. The first and second light guides receive the light energy from the light source and have respective guide proximal ends. A multiplexer directs the light energy toward the guide proximal ends of the first and second light guides. The optical alignment system determines an alignment of the light energy relative to at least one of the guide proximal ends and adjusts the positioning of the light energy relative to the at least one of the guide proximal ends based at least partially on the alignment of the light energy relative to the at least one of the guide proximal ends.

An automated laser-surgery system for performing a closed-loop surgical procedure is disclosed. The procedure includes forming a post-procedural goal based on a three-dimensional (3D) image of a surgical site, planning a path for a surgical laser signal based on the post-procedural goal, performing a procedural pass by steering the surgical laser signal along the path, measuring the surface of the surgical site after the procedural pass, updating a model based on the measured effect at the surgical site, and evaluating the success of the procedural pass based on the surface measurement and the post-procedural goal. If necessary, a new path is planned based on the post-procedural goal and the surface measurement a new pass based on that path is performed, and the surface is again measured to evaluate the success of the new pass. These operations are repeated as a closed-loop sequence as many times as necessary to achieve success.

A method for laser assisted delivery of therapeutic agents includes selectively controlling a valve connected to a first channel disposed within a first sidewall of a nozzle, applying, through the first channel, a first substance to penetrate dermis to a predetermined depth, and administering, through a second channel unconnected with the valve and disposed within a second sidewall of the nozzle, a second substance to remove debris.

A medical handpiece having a laser irradiation unit connected to a body for generating a laser beam, so as to irradiate a subject with the laser beam; a laser tip which is brought into contact with a predetermined surgical site of the subject so as to guide the laser thereto; a sensor installed in the laser tip so as to measure pressure applied by the laser tip to the predetermined surgical site; and a processor for checking whether the measured pressure is within the pressure range set for the predetermined surgical site, determining, according to the result of the checking, whether the pressure applied to the predetermined surgical site needs to be adjusted, and performing control such that a guide signal for the laser tip is output.

Provided herein is a multifunctional aesthetic system including a housing, an electromagnetic array situated in the housing and having one or more electromagnetic radiation (EMR) sources, a controller in electronic communication with the array to operate the one or more of the EMR sources to direct the EMR beam to a treatment area, and one or more sensors in electronic communication with the controller for providing feedback to the controller based on defined parameters to allow the controller to adjust at least one operating condition of the multifunctional system in response to the feedback.

A method includes generating a plurality of primary beams from a laser beam, and generating, from a primary beam one or more secondary beams. The method also includes focusing the first secondary beam to a first focal region in the target tissue and the second secondary beam to a second focal region in the target tissue. The first focal region and the second focal region can be located at different depths in the target tissue.