A method for laser assisted delivery of therapeutic agents includes selectively controlling a valve connected to a first channel disposed within a first sidewall of a nozzle, applying, through the first channel, a first substance to penetrate dermis to a predetermined depth, and administering, through a second channel unconnected with the valve and disposed within a second sidewall of the nozzle, a second substance to remove debris.

An ophthalmological laser device for treatment of eye tissue is disclosed, comprising a base station having a treatment laser source configured to generate a treatment laser beam, an application head, an arm arranged between the base station and the application head, wherein the arm is configured to provide a beam path for the treatment laser beam, the arm having at least one joint, and a scanner arranged in the joint and configured to dynamically deflect the treatment laser beam about two axes, wherein the treatment laser beam upstream of the scanner is collinear with an axis of rotation of the joint and an orientation of the scanner is dependent on a movement of the joint.

A treatment device for fractional laser-based skin treatment includes an emission window having an elongated area and predefined locations that are arranged in an elongated array which extends along a treatment axis of the window. A treatment generator has a treatment laser for emitting laser light towards skin tissue from the predefined locations in the emission window for generating, in use, laser-based lesions inside the skin tissue. The treatment device also includes a motion sensor for sensing motion of the treatment device relative to the skin surface, and a controller for determining a non-zero sequence of at least one of the predefined locations from which laser light is consecutively emitted in dependence on the sensed motion. The controller allows generation of the non-zero sequence when the sensed motion of the treatment device relative to the skin surface only has a component in a direction parallel to the treatment axis.

Improved, efficient devices/methods for medical and cosmetic applications, involving the delivery of laser energy to tissue are provided. In a preferred embodiment a portable, easy-to-use laser system comprises at least one laser source operating at one or more laser wavelengths; an electronic visual display having a n-dimensional input interface to set/select laser parameters; and at least one waveguide optically coupled to the laser source to convey laser radiation to a treatment site. The n-dimensional input interface inputs/selects lasing parameters which allows the selection of a combination of output wavelengths and powers by simply touching the electronic visual display. Method of use comprises the steps of placing at least one waveguide at preselected treatment site; selecting a combination of laser wavelengths and power by interacting with an electronic visual display; and irradiating the treatment site.

Systems for laser assisted delivery of therapeutic agents include an ultraviolet laser configured to produce a laser beam at a wavelength appropriate for tissue ablation; a lens configured to focus and direct the laser beam to a site, such that an opening is produced in a surface of the site's tissue; a nozzle having an aperture that emits the laser beam and that controls delivery of one or more agents to the site; and an imaging device configured to monitor a depth of penetration of the one or more agents into the site's tissue.

A system to perform a bypass procedure performed by an apparatus (100, 400, 600) comprising a steerable body portion (102, 450, 452) and at least one transducer (114, 414) controlled by at least one controller (610). The system may include one or more acts of transluminally detaching at least a portion of a first artery from connective tissue (423) of a chest wall (425) that is attached to the first artery by applying ultrasound signals of a first type emitted by the at least one transducer (114, 414) situated within the first artery; steering the detached portion of the first artery from a current location to a bypass location by applying a force from the steerable body portion, which is located outside of the first artery, to at least a portion of the detached portion of the first artery; and coupling the first artery to a target artery at the bypass location to establish flow communication between the first artery and the target artery.

A method includes generating a plurality of primary beams from a laser beam, and generating, from a primary beam one or more secondary beams. The method also includes focusing the first secondary beam to a first focal region in the target tissue and the second secondary beam to a second focal region in the target tissue. The first focal region and the second focal region can be located at different depths in the target tissue.

Methods and systems for laser assisted delivery of therapeutic agents include preparing a site with an ultraviolet laser beam, at a wavelength appropriate for tissue ablation, such that an opening is produced in a surface of the site's tissue; and applying one or more agents to the prepared site, such that the agents penetrate the tissue through the opening to a predetermined depth.

A method and system for spot size selection wherein an indication of a spot size selection is received and a spot size is generated corresponding to the spot size selection by propagating an optical signal via one of the claddings of a dual-clad optical fiber. The system for spot size selection includes a plurality of lens arrays, at least one galvanometer, and a plurality of dual-clad fibers to propagate an optical signal from one of the plurality of lens arrays.

An apparatus that performs a bypass procedure includes a steerable body portion and at least one transducer controlled by at least one controller. The system may include one or more acts of transluminally detaching at least a portion of a first artery from connective tissue of a chest wall that is attached to the first artery by applying ultrasound signals of a first type emitted by the at least one transducer situated within the first artery; steeling the detached portion of the first artery from a current location to a bypass location by applying a force from the steerable body portion, which is located outside of the first artery, to at least a portion of the detached portion of the first artery; and coupling the first artery to a target artery at the bypass location to establish flow communication between the first artery and the target artery.