Systems and methods are disclosed that facilitate the local therapy of tissue within the body. In some example embodiments, infrared laser pulses are locally delivered, via optical fiber, to an intracorporal target tissue region and are provided with pulse conditions suitable for causing local tissue disruption and liquification, leading to fine tissue disruption, tissue homogenization, and removal of vasculature and interstitial fluid channels, and enabling passage of the distal tip of the optical fiber into the target tissue region without substantial tissue deformation and damage along a preferred surgical pathway. When optical fiber emitting such pulses is employed to penetrate tumor tissue, the resulting reduction of interstitial fluid pressure facilitates the subsequent injection of a drug into the tumor, enabling the drug to remain localized within the tumor with reduced diffusion. The tumor disruption and subsequent drug delivery may be performed using an integrated optical and fluidic delivery device.

Embodiments of the invention include a method of initiating an optical fiber of a tip assembly to form a finished tip assembly. In some embodiments, at least a portion of a distal portion of the optical fiber is coated with an energy absorbing initiating material. In some embodiments, the initiating material is an enamel material including a mixture of brass (copper and zinc) flakes or aluminum flakes in a solution of organic solvents. After the initiating material dries, a diode laser is fired through the optical fiber. The laser energy is at least partially absorbed in the initiating material and ignites the organic solvents. This combustion melts the material of the optical fiber, and impregnates the optical fiber with the metal flakes of the initiating material. The resulting initiated optical fiber is thus permanently modified so that the energy applied through the fiber is partially absorbed and converted to heat.

A light radiating device (1A) performs solidification or cauterization of a biological tissue (PL) by radiating a light beam (BM). A light source (10A) emits the light beam (BM). An optical waveguide (20A) is a member being provided with a reflection surface (21A) totally reflecting the light beam (BM) on an inner circumferential side wall, causing the light beam (BM) emitted from the light source (10A) to enter a part enclosed by the inner circumferential side wall from one end, and sending the light beam (BM) to the other end. A catoptric system (30A) reflects the light beam (BM) sent to the other end of the optical waveguide (20A) and condenses the light beam (BM) on the biological tissue (PL).

An apparatus for aiding the removal of cataracts in which an optical fiber delivers sufficient optical energy of the correct wavelength, pulse duration to achieve controlled non-thermal and non-acoustic dissolution of hard cataract tissue.

A laser device for photocoagulation surgery is disclosed, wherein the laser device includes a multi-wavelength laser source having a first direction and a second direction different from the first direction. The laser device includes a positioning light source, a first laser light source, a first lens, a second laser light source, a second lens, a third laser light source, a third lens, a fourth laser light source and a fourth lens. The positioning light source configured to project a positioning visible light along the first direction, wherein the positioning visible light has a specific wavelength being about 635 nm. The first laser light source configured to project a first laser light having a first wavelength along the second direction. The first lens disposed in a main optical path of the positioning visible light, and configured to receive the first laser light and reflect the first laser light along the first direction.

An apparatus for aiding the removal of cataracts in which an optical fiber delivers sufficient optical energy of the correct wavelength, pulse duration to achieve controlled non-thermal and non-acoustic dissolution of hard cataract tissue.

A method of dermocosmetic treatment for skin tissue includes a plurality of treatment laser light sources which are in communication with a rectangular-shaped optical fiber; the optical fiber includes a proximal end to receive laser light from the plurality of treatment laser light sources and a distal end to transmit overlapping laser light to the area of skin tissue to be treated; the plurality of treatment of laser light sources are activated to impinge one or more rectangular-shaped laser light images within one or more rectangular-shaped areas.

An end-firing surgical laser fiber suitable for Thulium Laser Fiber lithotripsy applications includes a standoff that extends beyond the distal end surface of the fiber to prevent contact between the end face of the fiber and a targeted stone. The standoff may either (1) extend along only one side of or partially around a circumference of the fiber, so that dust from the pulverized stone can freely flow downstream from the treatment site without being trapped by or accumulating on the standoff, or (2) include at least one flushing port that prevents dust accumulation by permitting passage of dust from within the standoff. Flushing of dust from within the standoff may be facilitated by including a source of fluid to entrain the dust and carry it through the flushing port.

An apparatus for laser treatment, which may provide precise laser treatment in a body, the apparatus for laser treatment including: a light irradiation unit including an optical fiber; a catheter having an expansion fixing portion into which the optical fiber is inserted; a sensor monitoring unit including a plurality of sensors provided in the catheter; and a controller receiving measurement information from the sensor monitoring unit and controlling the light source Furthermore, the plurality of sensors include a shape information sensor inserted together with the optical fiber and configured to obtain internal shape information of the tubular tissue in a position of an optical fiber end to which light is irradiated, and in a cross-section, perpendicular to a longitudinal direction of the catheter, the shape information sensor is disposed in a central portion, together with the optical fiber.