Surgical tissue repair technologies incorporating nitric oxide releasing materials which release nitric oxide into the surrounding tissue. The surgical tissue repair technologies include tissue repair devices, such as surgical meshes, vascular stents, surgical grafts, irrigation solutions, and other internal surgical tissue repair materials. The nitric oxide releasing compound may be a S-nitrosothiol compound, such as s-nitroso-n-acetyl penicillamine (SNAP), s-nitrosoglutathione (GSNO), and mixtures thereof. The tissue repair devices may further include a catalyst to facilitate release of nitric oxide. The devices may include a substrate coated with a coating incorporating the same or different nitric oxide releasing compound. The devices may include a substrate impregnated with the nitric oxide releasing compound and coated with a polymer-based coating incorporating the same or different nitric oxide releasing compound. The polymer-based coating may include diazeniumdiolate groups (NONOate groups). The polymer-based coating may include a polyethyleneimine cellulose NONOate polymer.

Described are surgical implants that include releasable reinforcement, and related methods, particular example implants and methods being useful for treating pelvic tissue, cardiac tissue, and hernia, wherein the releasable reinforcement can be released (removed or disabled) during a surgical procedure to affect a mechanical property of the implant or a portion of the implant.

A human implant arrangement for permanently constricting a human tissue structure in a longitudinal direction. The human implant arrangement includes a longitudinal first anchoring part having lateral self-anchoring elements which have a first longitudinal anchoring orientation, a connection part which does not have anchoring elements, and a longitudinal second anchoring part which is connected in a longitudinal orientation to the longitudinal first anchoring part via the connection part. The longitudinal second anchoring part has lateral self-anchoring elements which have a second longitudinal anchoring orientation which is reverse to the first longitudinal anchoring orientation. A total length of the human implant arrangement is not larger than 40 mm.

Apparatus and methods are provided for treating urinary incontinence, fecal incontinence, and other pelvic defects or dysfunctions, in both males and females, using one or more lateral implants to reinforce the supportive tissue of the urethra. The implants can be configured as a sling device having at least one extension arm and a tissue support portion having an eyelet, wherein a portion of the at least one extension arm is adapted to slide through and adjustably attach with the eyelet.

A medical sling for supporting an anatomical feature having ends that are tapered using a folding fixture and then thermoset. The thermoset ends hold the bunched or folded shape thus allowing the ends to be removed from the fixture and placed into a mold assembly where anchors are molded over the ends.

An implantable device for penile construction can comprise an anchor plate and at least one attachment member. The anchor plate can be configured to engage with a first portion of a pelvic bone of a patient. The anchor plate can comprise a prosthesis attachment interface configured to be coupled to a penile prosthesis, and at least one attachment member configured to attach to the anchor plate. The at least one attachment member can be configured to engage with a second portion of the pelvic bone of the patient. The engagement of the anchor plate with the first portion of the pelvic bone and the engagement of the attachment member with the second portion of the pelvic bone can couple the pelvic bone between the anchor plate and the at least one attachment member.

A surgical device is provided. The surgical device includes a housing adapted for mounting on a finger of a user; and at least one guide tube attached along a length of the housing. The guide tube is configured for guiding a tissue repair implant from a proximal opening to a distal opening thereof.

One or more sensors are incorporated onto one or more of an implantable device and a surgical tool used for placement and/or adjustment of the implantable device. The implantable device includes an adjustable membrane element for controllable coaptation of a body lumen, such as coaptation of a urethra as treatment for urinary incontinence. In various embodiments, the one or more sensors can be configured to detect information indicative of at least one of a shape of the adjustable membrane element, a position of the adjustable membrane element relative to the body lumen, or a shape of the body lumen.

Various surgical introducer needle and anchor systems are provided. The systems can include an introducer needle and a tissue support implant or sling device. The implant device can include one or more anchoring devices. The introducer needle device can include a handle assembly and a needle assembly. The needle assembly can include a generally hollow needle, and a wire traversable therein. The wire can include a distal tip adapted to selectively retract or withdraw from the engaged anchoring device upon deployment of the anchor and/or implant.

Apparatus and methods are provided for treating urinary incontinence, fecal incontinence, and other pelvic defects or dysfunctions, in both males and females, using one or more lateral implants to reinforce the supportive tissue of the urethra. The implants can be configured as a sling device having at least one extension arm and a tissue support portion having an eyelet, wherein a portion of the at least one extension arm is adapted to slide through and adjustably attach with the eyelet.