Provided is a medical base material that is suitable for regeneration of a cardiovascular system being exposed to high pressure from a lumen, such as an aorta and is absorbed by a living body after transplantation. The medical base material of the present invention has a sheet shape, a tube shape, or a combined shape thereof and is used for regeneration of a cardiovascular system by being transplanted in a body. The medical base material has a multilayer structure at least including an inner layer to be arranged on the intimal side of the cardiovascular system and an outer layer to be arranged on the adventitial side of the cardiovascular system from the inner layer and made from a material at least including a stereo complex polylactic acid. The layer to be arranged on the adventitial side of the cardiovascular system from the inner layer is formed in a porous form such that a nutrient blood vessel reaches the inner layer or enters the vicinity of the inner layer.

A system for applying a fiber matrix on a tubular member is provided. A mandrel, configured for atraumatic placement within the tubular member, is included. Methods for atraumatic placement of a mandrel into a tubular member are also provided.

The present invention relates to methods for recellurization of blood vessels. This method is particularly useful for producing an allogeneic vein, wherein a donor vein is decellularized and then recellularized using whole blood or bone marrow stem cells. The allogeneic veins produced by the methods disclosed herein are particularly advantageous for implantation or transplantation into patients with vascular diseases.

Provided is a graft material capable of securing a sufficient space for regenerated tissue in the implantation site, and thereby promoting the regeneration of a blood vessel. Specifically, the present invention provides a revascularization graft material including an outer tube and an inner tube each being formed by knitting twisted yarns of biodegradable single yarns into a hollow tubular structure, wherein there is provided, in the lumen of the outer tube, at least one inner tube having an outer diameter smaller than the lumen diameter of the outer tube. The inner tube functions as a core material for the outer tube, and accordingly the revascularization graft material is excellent in kinking resistance, and the occlusion of the lumen hardly occurs.

A textile engineered prosthetic includes a continuous tube and at least one band of increased thickness formed over a portion of the continuous tube. The continuous tube includes a body portion and a bifurcated portion. The band of increased thickness forms a biomimetic surface. A bioreactor system includes a bioreactor container including a first compartment, a second compartment, a first membrane separating the first and second compartments, a third compartment, and a second membrane separating the second and third compartments. The bioreactor system also includes a woven textile prosthetic integrated with the bioreactor container in the second compartment to form a single bioreactor unit. A furcated textile article includes a continuous tube having a body portion and a furcated portion bifurcated N times from the body portion. The furcated textile article is a continuous woven piece formed from N shuttles of a shuttle loom, where N is at least two.

Disclosed herein is a method of manufacturing a vascular graft comprising disposing cells of a first cell type on a core having a textured surface, wherein the textured surface comprises a plurality of spaced features, the spaced features being arranged in a plurality of groupings, the groupings of spaced features being arranged with respect to one another so as to define a tortuous path when viewed in a first direction; growing the cells to form a primary cell-seeded construct, wherein the primary cell-seeded construct has a textured inner surface that is a negative image of the textured surface of the core; contacting the primary cell-seeded construct with a second cell type to form a secondary cell-seeded construct; and removing the core to produce the vascular graft.

An intravascular cell therapy device comprises a scaffold (2, 12) that is radially adjustable between a contracted orientation suitable for transluminal delivery to a vascular locus and an expanded orientation, and a biodegradable matrix provided on at least a portion of the scaffold that is suitable for seeding with cells and degrades in a vascular environment. The scaffold is configured to have a distal piercing tip (5) when in a deployed orientation. The scaffold comprises a plurality of sidewall panels (3, 13, 14) arranged around a longitudinal axis of the scaffold, and adjustable couplings (4) between the panels configured for adjustment between an expanded configuration and a contracted orientation, and in which each sidewall panel comprises a matrix suitable for seeding with cells.

The present invention relates to methods for recellurization of blood vessels. This method is particularly useful for producing an allogeneic vein, wherein a donor vein is decellularized and then recellularized using whole blood or bone marrow stem cells. The allogeneic veins produced by the methods disclosed herein are particularly advantageous for implantation or transplantation into patients with vascular diseases.

A graft containing a scaffold that includes a matrix in which are positioned mesenchymal progenitor cells (MPCs) has the capacity to substantially improve wound healing, including wounds resulting from injury to nerve, bone and vascular tissue. MPCs can be harvested from debrided muscle tissue following orthopaedic trauma. The traumatized muscle-derived progenitor cells are a readily available autologous cell source that can be utilized to effect or improve wound healing in a variety of therapeutic settings and vehicles.

The artificial blood vessel comprises a cortex layer, a fibroblast layer, a smooth muscle cell layer, an endothelial cell layer and an inner cavity. According to the artificial blood vessel, the endothelial layer, the smooth muscle cell layer, the fibroblast layer and the cortex layer are orderly arranged in a three-dimensional space by utilizing integrated technologies of plasma spraying, electrospraying, electrospining, intra-mold pouring and 3D printing; anticoagulant activity of the artificial blood vessel is enhanced by adopting an anticoagulation factor; step-by-step induced differentiation of stem cells in the artificial blood vessel is realized by adopting a growth factor controlled release method; and the artificial blood vessel is cultured by a pulsatile reactor, so that the artificial blood vessel structurally and functionally simulates natural animal blood vessels and provides a corresponding substitute for vascular transplantation and repair.