The imperfect hemodymamics and non-endothelialized surface of the BT shunt and RV-PA conduit can be improved by utilizing a shape that has more uniform flow and lower shear stress. Accordingly, the shunt will have an acute takeoff angle with a fluted inlet portion that eliminates fluid separation and maintains the shear stress within or near the physiologic range. The distal aspect of the shunt may be fluted in one or both directions along the pulmonary artery to improve the flow transition and reduce the shear forces on the posterior wall the pulmonary artery. An autologous umbilical vein may be used as the shunt with fluted proximal and distal portions with an autologous endothelialized surface to minimize platelet deposition and thrombus formation. The umbilical vein shunt may have an external support for diameter constraint and maintaining the hemodynamically optimized fluted design.

Exemplary embodiments of apparatuses and methods of providing an endovascular′dock within a blood vessel are provided. An apparatus for vascular surgery can be provided, having an external tubular graft capable of expansion and configured to be placed within a sheath in an unexpended state, a first tubular structure provided internally within the external tubular graft and configured for placement of a graft therein, and a second tubular structure provided internally within the external tubular graft and configured for placement of a graft therein. Stent grafts can be provided along each tubular structure to a corresponding blood vessel such that blood flow is provided to the blood vessel from the apparatus within the stent grafts to each blood vessel, blocking the blood flow directly from the aneurysm.

A delivery system for a medical device includes a proximal tip having a curved groove formed therein and a pre-loaded catheter disposed in the groove such that the pre-loaded catheter is disposed at least partly circumferentially with regard to the proximal tip. A guidewire can be advanced through the pre-loaded catheter and extended laterally from the delivery system.

Some embodiments are directed to a deployment system for deploying a stent graft within a passageway, including a delivery catheter having an outer sheath, a proximal end, and a distal end, a stent having a first end and a second end, a graft having a first end and a second end, and at least one connecting element extending from the second end of the stent to the first end of the graft so as to connect the stent to the graft. In some embodiments, the stent can be supported within the outer sheath at a first axial position in a collapsed state, and the graft can be supported within the outer sheath at a second axial position different than the first axial position in a collapsed state, such that the stent does not overlap or substantially overlap the graft in the collapsed state within the deployment system.

Provided are a stent graft and a stent-graft placement device with which it is possible to suitably align a side opening of a main blood vessel stent graft and a blood vessel opening of a branch blood vessel. The stent graft (10) is to be placed in a tubular tissue and is equipped with: a skeleton portion (11); a tubular graft portion (12) having, in part of a tube wall, a side opening (opening 121a of branch portion 121) that communicates with the lumen, the graft portion being provided along the skeleton portion; and a position adjustment portion (13) capable of adjusting the relative position of the side opening in the graft portion when the stent graft is placed in the tubular tissue.

Described herein are bioengineered constructs and methods of producing the same. The constructs and methods disclosed herein can be applied towards, for example, the generation of vascular grafts to treat cardiovascular disease.

A stent graft includes a tubular aortic component that defines a lumen and a fenestration with a pocket at the fenestration. At least one proximal tunnel graft extends proximally within the lumen from the proximal opening of the pocket and is secured at a proximal end to the tubular component, and at least one distal tunnel graft extends distally within the lumen from the distal opening of the pocket and is secured at a distal end to the tubular aortic component. The stent graft can further include at least one branch stent graft, each of which extends through the fenestration and within at least one of the proximal tunnel graft or the distal tunnel graft. The stent graft can be implanted in a patient to thereby treat an aneurysm, such as a suprarenal or thoracoabdominal aortic aneurysm.

A quick-connector for use with an autoretroperfusion and hypothermia system and methods of using the connector. The connector comprises a coolant inlet, a coolant outlet, a coolant reservoir, a blood lumen outlet, a blood lumen inlet, and a blood lumen, whereby the coolant outlet is configured to accept a cooling product from the reservoir, the reservoir is configured to accept cooling product from the coolant inlet. Flowing blood powered by the patient's heart may enter the connector through the blood lumen inlet, travel through the blood lumen while being cooled by cooling product in the reservoir, and leave the connector through the blood lumen outlet. The temperature of blood leaving the connector can be measured at the blood lumen outlet. Catheters can be attached to the blood lumen inlet and blood lumen outlet to receive and send blood, respectively. A cooling system can be attached to the coolant inlet and coolant outlet to provide a source of cooling product.

Methods, systems, devices and apparatuses to support the walls of one or more blood vessels and perfuse blood through the one or more blood vessels. The stent device allows perfusion through one or more vessels. The stent device includes a tubular member. The tubular member has a single body that includes a main body lumen, a bypass lumen and one or more branch lumens. The tubular member is configured to be inserted into the aorta. The main body lumen is configured to expand and support a vessel wall of the aorta and the one or more branch lumens are configured to connect to one or more extension grafts that extend within one or more branch vessels. The stent device includes multiple rings of stents. The multiple rings of stents are positioned within the tubular member and are configured to be expandable to expand the tubular member to support the tubular member against the vessel walls.

The present invention relates to a vascular implant for implanting into a blood vessel of a patient, the vascular implant comprising a hollow-cylindrical main body with a proximal end and a distal end, a main body lumen and a longitudinal axis, and at least one hollow-cylindrical side body that branches off from the main body and comprises a side body lumen, the side body lumen being in fluid communication with the main body lumen, wherein the hollow-cylindrical main body and the at least one hollow-cylindrical side body are formed in one piece from one single planar sheet of graft material.