Certain embodiments are directed to lenses, devices and/or methods. For example, a lens for an eye having an optical axis and an aberration profile along its optical axis, the aberration profile having a focal distance and including higher order aberrations having at least one of a primary spherical aberration component C(4,0) and a secondary spherical aberration component C(6,0). The aberration profile may provide, for a model eye with no aberrations and an on-axis length equal to the focal distance: (i) a peak, first retinal image quality (RIQ) within a through focus range that remains at or above a second RIQ over the through focus range that includes said focal distance, where the first RIQ is at least 0.35, the second RIQ is at least 0.1 and the through focus range is at least 1.8 Diopters; (ii) a RIQ of 0.3 with a through focus slope that improves in a direction of eye growth; and (iii) a RIQ of 0.3 with a through focus slope that degrades in a direction of eye growth. The RIQ may be Visual Strehl Ratio or similar measured along the optical axis for at least one pupil diameter in the range 3 mm to 6 mm, over a spatial frequency range of 0 to 30 cycles/degree inclusive and at a wavelength selected from within the range 540 nm to 590 nm inclusive.

Methods and apparatus are provided for adaptively focusing a lens. In one approach, electromagnetic energy is employed to modify a shape or thickness of a lens such that its refractive power and focal length are modified. In one aspect, a lens embodying adaptive focus features requires low power, and can be adjusted quickly. One or a plurality of electromagnets can be employed to compress or separate end portions of an embedded haptic, the force from which acts to alter the shape of the haptic, thus modifying the refractive power and focal length of a lens.

A corneal implant designed for correcting irregularities of the corneal curvature of a subject, the implant having a dome-shaped structural body configured to impose a regular curvature to the corneal portions designed to be in contact with the implant. The structural body includes an outer peripheral ring and an inner reticular structure. The inner reticular structure includes at least one first and one second series of beams intersecting each other. The beams of the first series have a respective first end connected to the outer peripheral ring. The total area of void portions within the meshes of the reticular structure is between 50 and 99.9% of the surface area of the reticular structure. The inner reticular structure includes an innermost peripheral ring and the beams of the second series include annular beams arranged concentrically to each other. The reticular structure includes a third series of beams, having a respective first end connected to the outer peripheral ring and a respective second end connected to an annular beam defining a circumference or perimeter greater than the circumference or perimeter defined by the innermost peripheral ring.

An example method for cutting a plurality of lenticules from a donor cornea includes receiving a donor cornea, cutting a first layer of a first set of lenticules from the donor cornea, and cutting a second layer of a second set of lenticules from the donor cornea. The lenticules are cut according to a pattern that to maximizes the number of lenticules, thereby maximizing the number of implants from the single donor cornea.

An example implant handling device includes a body. The body includes a flattened end configured to receive a corneal implant and keep the corneal implant from rolling or folding. The flattened end has a width and a height, the width being greater than the height. The body includes a slit opening to the flattened end, the slit opening configured to allow the corneal implant to pass into the flattened end.

Exemplary light control devices and methods provide a regional variation of visual information and sampling (“V-VIS”) of an ocular field of view that improves or stabilizes vision, ameliorates a visual symptom, reduces the rate of vision loss, or reduces the progression of an ophthalmic or neurologic condition, disease, injury or disorder. The V-VIS devices and methods generate a moving aperture effect anterior to a retina that samples and delivers to the retina environmental light from an ocular field of view at a sampling rate between 50 hertz and 50 kilohertz. Certain of these V-VIS devices and methods may be combined with augmented or virtual reality, vision measurement, vision monitoring, or other therapies including, but not limited to, pharmacological, gene, retinal replacement and stem cell therapies.

The invention relates to methods for the treatment or alleviation of an anterior corneal disorder in a subject in need thereof comprising removing corneal epithelial cells from an eye of said subject without removing any corneal tissue or other ocular tissue located posterior to the corneal epithelial cell layer; and positioning an overlay comprising a Bowman layer (BL), Descemet membrane (DM) and/or crystalline lens capsule on the anterior surface of said corneal tissue located posterior to the corneal epithelial cell layer. The invention further relates to freeze-dried and/or gamma irradiated Bowman layer, Descemet membrane and/or crystalline lens capsule and compositions comprising the same that are useful in such methods.

There is disclosed a surgical device comprising a handle (14) for releasable attachment to a cartridge (1) adapted to hold an endothelial corneal implant in a scrolled or double coiled configuration. The handle has a forward end for releasable attachment to the cartridge, a rearward end and a gripping portion (60) between said forward and rearward ends. The gripping portion is substantially planar so as to facilitate being gripped between finger and thumb. The handle incorporates a first flexible fluid conduit (61) for releasable fluid connection to the cartridge at the forward end of the handle. There is further disclosed a surgical device comprising a handle having a forward end and a rearward end and a gripping portion between said forward and rearward ends. The gripping portion is substantially planar so as to facilitate being gripped between finger and thumb. The surgical device also comprises a cartridge having a forward end, a rearward end and a hollow interior that is open at the forward and rearward ends, the rearward end for releasable attachment to the forward end of the handle, and the hollow interior of the cartridge adapted to hold an endothelial corneal implant in a scrolled or double coiled configuration. In addition, the surgical device comprises a first flexible fluid conduit incorporated in the handle, wherein the first flexible fluid conduit is configured for releasable fluid connection to the rearward end of the cartridge at the forward end of the handle.

A corneal inlay device comprising a flat or flat-like base and a dome or droplet top. The corneal inlay can be used to treat, for example without limitation, presbyopia, while reducing or eliminating the risk of a patient developing corneal haze.

A scleral lens with a fenestration and pockets. One fenestration or a plurality of annularly-distributed fenestrations are provided in an optic zone of the scleral lens; and two or more pockets are provided in a pocket annular zone on a posterior surface of the optic zone. The pockets are configured to trap gas bubbles near the fenestration, where the fenestration is located radially outward from the pocket annular zone and not located in a transition zone of the scleral lens, and the transition zone is configured to be located above the limbus of the eyeball during wearing of the scleral lens. The lens of the present invention will not be adsorbed to the cornea and can be worn comfortably and maintain clear visual acuity for up to 12 hours.

The present invention provides a scleral lens with a fenestration and pockets. One fenestration or a plurality of annularly-distributed fenestrations are provided in an optic zone of the scleral lens; and two or more pockets are provided in a pocket annular zone on a posterior surface of the optic zone. The pockets are configured to trap gas bubbles near the fenestration, where the fenestration is located radially outward from the pocket annular zone and not located in a transition zone of the scleral lens, and the transition zone is configured to be located above the limbus of the eyeball during wearing of the scleral lens. The lens of the present invention will not be adsorbed to the cornea, and can be worn comfortably and maintain clear visual acuity for up to 12 hours.