An accommodating intraocular lens (AIOL) for implantation within a capsular bag of a patient's eye comprises first and second components coupled together to define an inner fluid chamber and an outer fluid reservoir. The inner region of the AIOL provides optical power with one or more of the shaped fluid within the inner fluid chamber or the shape of the first or second components. The fluid reservoir comprises a bellows region with fold(s) extending circumferentially around an optical axis of the eye. The bellows engages the lens capsule, and a compliant fold region between inner and outer bellows portions allows the profile of the AIOL to deflect when the eye accommodates for near vision. Fluid transfers between the inner fluid chamber and the outer fluid reservoir to provide optical power changes. A third lens component coupled to the first or second component provides additional optical power.

Embodiments of the instant disclosure relate to intraocular drug delivery devices for and methods of, delivering at least one therapeutic agent to an eye of a subject. Methods include implanting an intraocular implant into the eye and adjacent to a fluid-permeable membrane of the eye of the patient. Intraocular implants are supported in a position at a surface of the fluid-permeable membrane. Intraocular implants include a drug delivery component having at least one therapeutic agent embedded within a non-bioerodible, non-biodegradable polymer matrix. Devices and methods disclosed herein can further include delivering the at least one therapeutic agent to the eye of the subject according to a near zero-order elution rate of the at least one therapeutic agent.

An apparatus for implant into an eye. The apparatus may comprise a receptacle configured to receive an optic; a flange circumscribing the receptacle, the flange configured to be disposed in the ciliary sulcus of the eye; and a fenestration through the flange, the fenestration configured to allow aqueous humor to pass anteriorly from the ciliary body to the trabecular meshwork of the eye. Some or all of the apparatus may have an oleophobic coating. For example, some embodiments of the flange may have an oleophobic coating. In some embodiments, the fenestration may be inferior to the receptacle. Additionally, or alternatively, the apparatus may further comprise at least two haptics coupled to the flange.

An intraocular lens includes a deformable optic, a rigid optic, and a support structure. The deformable optic is disposed about an optical axis and comprises a solid material and a deformable surface. The rigid optic is disposed about the optical axis and comprises a solid material and a rigid surface. The support structure is operably coupled to at least one of the optics for pressing the deformable surface and the rigid surface together in response to or in the absences of an ocular force, whereby at least a portion of the deformable surface changes shape such that the optical power of the at least a portion of the deformable surface and/or the intraocular lens changes by at least 2 Diopter.

An intraocular lens includes a deformable optic, a rigid optic, and a support structure. The deformable optic is disposed about an optical axis and comprises a solid material and a deformable surface. The rigid optic is disposed about the optical axis and comprises a solid material and a rigid surface. The support structure is operably coupled to at least one of the optics for pressing the deformable surface and the rigid surface together in response to or in the absences of an ocular force, whereby at least a portion of the deformable surface changes shape such that the optical power of the at least a portion of the deformable surface and/or the intraocular lens changes by at least 2 Diopter.

An ophthalmic multifocal switchable lens includes a deformable element manifesting elevated strain with a formable surface of a multifocal surface shape to provide far and near vision. A transparent chamber is filled with optical matching fluid adjacent to the side of the deformable element opposite to the formable surface. The optical matching fluid has a refractive index that matches a refractive index of the deformable element material. A holding chamber is also filled with the optical matching fluid and connected with the transparent chamber with a means for preventing the optical fluid from being transported from the holding chamber to the transparent chamber which would reduce a strain of the deformable element. A split of light between far and near vision of the multifocal switchable lent changes upon a removal of the means to allow a flow of the optical matching fluid into the transparent chamber.

The subject matter of the disclosure relates generally to a MEMS-based position-sensing system and lenses, for example, contact lenses and intra-ocular lenses, manufactured with the position-sensing system employing one or more angular and/or linear accelerometers and/or pressure transducers and methods for detecting position and motion of an eyeball and/or head utilizing the position-sensing contact lenses.

An accommodating intraocular lens (AIOL) for implantation within a capsular bag of a patient's eye comprises first and second components coupled together to define an inner fluid chamber and an outer fluid reservoir. The inner region of the AIOL provides optical power with one or more of the shaped fluid within the inner fluid chamber or the shape of the first or second components. The fluid reservoir comprises a bellows region with one or more folds of the bellows extending circumferentially around an optical axis of the eye. The bellows engages the lens capsule, and a compliant fold region between the inner and outer bellows portions allows the profile of the AIOL to deflect when the eye accommodates for near vision. Fluid transfers between the inner fluid chamber and the outer fluid reservoir to provide optical power changes when the eye accommodates.

A medicament reservoir for an intraocular lens has a medicament, a through-hole, a first medicament reservoir clearance which communicates with the through-hole, a first web which delimits the first medicament reservoir clearance, a first end face which delimits the through-hole, and a second end face which is disposed so as to face away from the first end face and to delimit the through-hole. The through-hole in a region of the first end face has a first longitudinal end and in a region of the second end face has a second longitudinal end. The medicament reservoir has a displacement direction oriented from the first longitudinal end to the second longitudinal end. The first medicament reservoir clearance is formed such that the through-hole is accessible from outside the medicament reservoir via the first medicament reservoir clearance in a medicament reservoir radial direction in terms of the displacement direction.

Accommodating intraocular lenses including an optic having an anterior element and a posterior element defining an optic fluid chamber, wherein the optic is aspheric across all powers throughout accommodation or disaccommodation. Intraocular lenses, optionally accommodating, where an optic portion is centered with a midline of a height of the peripheral portion, the height measured in the anterior to posterior direction.