The present invention provides apparatus for endovascularly replacing a patient's heart valve. The apparatus includes a replacement valve and an expandable anchor configured for endovascular delivery to a vicinity of the patient's heart valve. In some embodiments, the replacement valve is adapted to wrap about the anchor, for example, by everting during endovascular deployment. In some embodiments, the replacement valve is not connected to expandable portions of the anchor. In some embodiments, the anchor is configured for active foreshortening during endovascular deployment. In some embodiments, the anchor includes expandable lip and skirt regions for engaging the patient's heart valve during deployment. In some embodiments, the anchor comprises a braid fabricated from a single strand of wire. In some embodiments, the apparatus includes a lock configured to maintain anchor expansion.

Embodiments of a prosthetic heart valve are disclosed. An implantable prosthetic valve can include an annular frame having an inflow end, an outflow end and a central longitudinal axis extending from the inflow end to the outflow end. The valve can include a valvular structure including two or more leaflets, each of the two or more leaflets having a leaflet inflow edge positioned at least partially outside of the frame and a leaflet outflow edge positioned within the frame, wherein at least a portion of each of the leaflet inflow edges is unsupported by the frame.

Prosthetic mitral valves described herein can be deployed using a transcatheter mitral valve delivery system and technique to interface and anchor in cooperation with the anatomical structures of a native mitral valve. This document describes prosthetic heart valve designs and techniques to manage blood flow through the left ventricular outflow tract. For example, this document describes prosthetic heart valve designs and techniques that reduce or prevent obstructions of the left ventricular outflow tract that may otherwise result from systolic anterior motion of an anterior leaflet of the native mitral valve.

A prosthetic valve assembly includes a prosthetic valve and an anchoring frame. The prosthetic valve includes a valve frame and a valve structure. The valve frame includes a plurality of struts and is expandable from a compressed configuration to an expanded configuration. The valvular structure includes leaflets. The valvular structure is disposed radially within and is coupled to the valve frame. The valvular structure is configured to allow blood flow through the prosthetic valve assembly in a first direction and to restrict blood flow through the prosthetic valve assembly in a second direction. The anchoring frame includes a plurality of struts. The anchoring frame is disposed radially outwardly from and is coupled to the valve frame. The struts of the anchoring frame comprise one or more tissue-engaging elements configured for contacting native tissue to help secure the prosthetic valve assembly at an implantation location.

A locking mechanism for a transcatheter delivery system is disclosed. As one example, the locking mechanism may comprise a first fixing member configured to be coupled to an introducer sheath, a second fixing member configured to be coupled to a handle of a delivery apparatus, and a locking arm configured to be removably coupled at a first end to one of the first fixing member and the second fixing member and fixedly or removably coupled at a second end to another one of the first fixing member and the second fixing member, wherein the locking arm is moveable between a first position where an axial position of the second fixing member is not fixed relative to the first fixing member via the locking arm and a second position where the axial position of the second fixing member is fixed relative to the first fixing member via the locking arm.

An implantable prosthetic device can include a radially expandable and compressible frame including an inflow end portion and an outflow end portion. The frame including a plurality of struts, and at least one expansion and locking mechanism having a first member, a second member extending at least partially into the first member, and a third member. The third member can include an engagement portion. The plurality of struts can include a first strut and a second strut pivotably coupled to one another to form an apex, the first strut having a first flange and the second strut having a second flange. When the frame is expanded, distal advancement of the third member can position the engagement member between the first and second flanges such that they engage the engagement member to resist pivoting of the first and second struts relative to one another to resist compression of the frame.

A stented valve including a stent structure including a generally tubular body portion having a first end, a second end, an interior area, a longitudinal axis, and a plurality of vertical wires extending generally parallel to the longitudinal axis around a periphery of the body portion, wherein the plurality of vertical wires includes multiple commissure wires and at least one structural wire positioned between adjacent commissure wires, and a plurality of V-shaped wire structures having a first end, a second end, and a peak between the first and second ends, wherein a first end of each V-shaped structure extends from a first vertical wire and a second end of each V-shaped structure extends from a second vertical wire that is adjacent to the first vertical wire, wherein each V-shaped structure is oriented so that its peak is facing in the same direction relative to the first and second ends of the body portion, and a valve structure including a plurality of leaflets attached to the stent structure within the tubular body portion.

A mitral valve system comprising a first docking component and a second valvular component that are delivered via a single delivery catheter. The first component is located distal to the second component and provides a detachable rail to allow the second component to accurately position and lock with the first component. The first component has fixation members that are activated by either by a torus balloon or via fiber that does not restrict blood flow during delivery or during fixation member activation.

The present invention relates to devices, assemblies and methods for monitoring radial expansion of a prosthetic valve during prosthetic valve implantation procedures.

The present disclosure provides a method for contracting heart tissue using a transcatheter annuloplasty system. The system includes a plurality of anchoring components, a flexible tightening string and a flexible delivery member. The tightening string is coupled with a first anchoring component and the delivery member. The method includes: implanting the first anchoring component into the heart tissue, the tightening string entering a body along with the first anchoring component, and a proximal end of the delivery member extending outside the body; delivering each of remaining anchoring components, along the delivery member, to the tightening string and implanting it into the heart tissue; and tightening the tightening string. Therefore, after the plurality of anchoring components are implanted at different positions, along a circumferential direction of the mitral annulus, the tightening string is tightened to adjust a spacing of the anchoring components so as to contract the heart tissue.