Methods and devices for correcting wear pattern defects in joints. The methods and devices described herein allow for the restoration of correcting abnormal biomechanical loading conditions in a joint brought on by wear pattern defects, and also can, in embodiments, permit correction of proper kinematic movement.

A proposed treatment of arthrosis/osteoarthritis in a joint of a mammal or human patient involves deposing a liquid material on at least one damaged surface of the joint. To accomplish this, a reservoir (110) is provided, which holds a volume of a biocompatible material in liquid form outside of a body containing the joint (J) to be treated. A proximal end (P) of a tub e-shaped instrument (120) is connected to the reservoir (110), and a distal end (D) of the instrument (120) is inserted into the joint (J). The liquid material is fed through the instrument (120) to the distal end (D) for deposition on the at least one damaged joint surface.

The material is configured to assume a solid form under predefined conditions (e.g. when cooling off, or being exposed to a specific type of radiation). When the material has the solid form, it has a resistance to wear adapted to replace a worn out joint surface.

A medical device for treating hip joint osteoarthritis by providing a joint surface is provided. The medical device comprises at least two artificial hip joint surface parts, wherein said at least two artificial hip joint surface parts are adapted to be connected to each other to form an artificial hip joint surface during an operation. Furthermore a method of treating a hip joint of a human patient by providing said the medical device is provided. The hip joint comprising a caput femur and an acetabulum, the method comprises the steps of: cutting the skin of said human patient, dissecting an area of the pelvic bone on the opposite side from said acetabulum, creating a hole in said dissected area, said hole passing through said pelvic bone and into said hip joint of said human patient, and providing said medical device to said hip joint, through said hole in said pelvic bone of said human patient.

A device and a method of treatment for osteoarthritis of a joint, such as the hip. The implant is an extensible cap that is placed over the femoral head.

The invention relates to a method for treating hip joint osteoarthritis with a medical device having a prosthetic part adapted to function as an articulating surface comprising a center axis generally coinciding with the acetabulum and the caput femur center axis when implanted. The method further comprises placing the prosthetic part in a through-going hole in the pelvic bone from the side opposite a concave portion of the acetabulum of the human patient, displacing at least one displaceable protruding supporting member connected to said prosthetic part such that the at least one displaceable protruding supporting member is configured to transfer load from the prosthetic part via the displaceable connection to the pelvic bone when being displaced relative said prosthetic part in a direction more perpendicular than parallel to the prosthetic part's center axis and being implanted.

Systems and method for delivery and positioning of a sheet-like surgical implant to a target site including a means of deploying and orienting the sheet-like implant within the body.

An implantable medical device for implantation in a mammal joint having at least two contacting surfaces is provided. The medical device comprises; an artificial contacting surface adapted to replace at least the surface of at least one of the mammal's joint contacting surfaces, wherein the artificial contacting surface is adapted to be lubricated, when implanted in said joint. Furthermore the medical device comprises at least one inlet adapted to receive a lubricating fluid from a reservoir, at least one channel at least partly integrated in the artificial contacting surface in connection with the at least one inlet for distributing the lubricating fluid to the surface of the artificial contacting surface. The medical device could be adapted to be operable by an operation device to receive the distributed lubricated fluid from a reservoir.

Methods, compositions, and systems are provided for characterization of modified nucleic acids. In certain preferred embodiments, single molecule sequencing methods are provided for identification of modified nucleotides within nucleic acid sequences. Modifications detectable by the methods provided herein include chemically modified bases, enzymatically modified bases, abasic sites, non-natural bases, secondary structures, and agents bound to a template nucleic acid.

A medical device for treating hip joint osteoarthritis by providing a joint surface is provided. The medical device has at least two artificial hip joint surface parts adapted to be connected to each other to form an artificial hip joint surface during an operation. A method of treating a hip joint of a human patient by providing the medical device is also provided. The method includes cutting the skin of the human patient, dissecting an area of the pelvic bone on the opposite side from the acetabulum, creating a hole in the dissected area passing through the pelvic bone and into said hip joint and providing the medical device to the hip joint, through the hole in the pelvic.

A method has been developed for repairing a cartilage lesion. The method includes bringing a three-dimensional porous substrate into direct contact with prepared bone. The three-dimensional porous substrate is fixedly coupled to a three-dimensional scaffold such that the substrate supports the scaffold. The three-dimensional porous substrate comprises at least three layers of woven fibers. The substrate is configured to be inserted into bone tissue including cartilage lesions such that the substrate and the scaffold replace the bone tissue including the cartilage lesions. The substrate and scaffold are further configured such that after the substrate and the scaffold have replaced the bone tissue including the cartilage lesions, the substrate and scaffold promote growth and integration of new bone tissue into the implant.