Compositions comprising a cartilage sheet comprising a plurality of interconnected cartilage tiles and a biocompatible carrier are provided. Methods of manufacturing cartilage compositions comprising a cartilage sheet comprising a plurality of interconnected cartilage tiles are also provided.

A surgical tool assembly is disclosed herein. The assembly includes a first guide tool portion configured to support an instrument. The first guide tool portion is configured to limit movement of the instrument relative to a patient site. A second guide tool portion is provided that is configured to receive at least one K-wire to stabilize the surgical tool assembly.

A tool configured to deliver a radially compressible hydrogel implant at a surgical site includes an introducer tube, a plunger provided inside the introducer tube and configured to travel from the proximal end of the introducer tube toward the distal end of the introducer tube urging the hydrogel implant through a sloped portion of the introducer tube radially compressing the implant before exiting through the distal end of the introducer tube, a handle connected to the introducer tube, and a clamp hingeably connected to the handle.

An prosthetic implant replaces hyaline cartilage in a synovial joint with a flexible polymer sliding surface, preferably of hydrogel, on a segmented support with an array of adjacent segments to which the hydrogel is molded. Adjacent segments are laterally and angularly displaceable permitting the implant to conform to rounded or irregular surfaces or to be rolled or folded for arthroscopic placement. Tension cables threaded through segments along a circuit can cinch segments together for stiffening the supporting layer and/or the cable can pull the implant against a bone surface. Adjacent segments can have inter-engaged structures. In some embodiments the segments are carried on a flexible foil or fibrous sheet.

A mould adapted to be introduced into a joint of a human patient for resurfacing at least one carrying contacting surface of said joint is provided. The mould is adapted to receive material for resurfacing at least one carrying contacting surface of said joint. The mould is further adapted to be resorbed by the human body or melt after having served its purpose.

In some embodiments the present invention provides perfusion bioreactors and cell culture scaffolds suitable for the preparation of tissue grafts, such as bone tissue grafts. In some embodiments, the perfusion bioreactors comprise a graft chamber and/or a graft chamber insert configured to hold a tissue graft having a certain shape and/or certain dimensions, and/or to allow culture of such tissue grafts under press-fit direct perfusion conditions. In some embodiments, the perfusion bioreactors comprise an equilibration chamber.

Methods and devices are provided for preparing and implanting tissue scaffolds. Various embodiments of scribing tools are provided that are configured to mark one or more predetermined shapes around a defect site in tissue. The shape or shapes marked in tissue can be used to cut a tissue scaffold having a shape that matches the shape or shapes marked in tissue. In one embodiment, the scribing tool used to mark a shape in tissue can also be used to cut the tissue scaffold.

A method of creating a wedge-shaped recess in a bone is disclosed. The method includes creating a cylindrical recess within a bone, positioning a tool within the cylindrical recess, radially expanding an articulating cutter of the tool and rotating the tool to remove additional bone along the cylindrical recess' side walls and create a wedge-shaped recess; wherein, a diameter of the bottom surface of the wedge-shaped recess is larger than a diameter of a surface opening of the wedge-shaped recess.

An implant for repairing an articular cartilage defect site including an implant fixation portion with an upper segment and at least one bone interfacing segment and a top articulating portion with an articulating surface and an engagement surface. The upper segment includes a supporting plate with a first locking mechanism segment. The engagement surface includes a second locking mechanism segment. The first locking mechanism segment with at least two channels is structured to couple to the second locking mechanism segment with at least two protrusions. The at least one bone interfacing segment structured for insertion into the articular cartilage defect site. An implant including an implant fixation portion, a top articulating portion, and a locking mechanism with a first locking segment coupled to the upper segment and a second locking segment coupled to the at least one engagement surface and structured to couple to the first locking segment.

A method of treating a hip joint of a human patient using a pelvic drill comprising a driving member, a bone contacting and an operating device for operating said driving member. The method comprise the steps of cutting the skin of the human patient, dissecting an area of the pelvic bone on the opposite side from the acetabulum, creating a hole in said dissected area using said pelvic drill, said hole passing through the pelvic bone and into the hip joint of the human patient, and providing at least one hip joint surface to the hip joint, through said hole in the pelvic bone of the human patient. In one embodiment the method includes inserting a needle or tube like instrument into the patient's body for filling a part of the patient's body with gas and thereby expanding a cavity within the body.