Implants, systems, instruments, methods, and kits for metatarsophalangeal joint arthroplasty may include metatarsal arthroplasty implants, repositioning guides, broach tools, inserter tools, and sterilizable packaging configured to facilitate metatarsal arthroplasty surgical procedures. The metatarsal arthroplasty implants may generally include an articular member having a convex articular surface, a concave bone-facing surface opposite the convex articular surface, and at least one side surface intermediate the convex articular surface and the concave bone-facing surface, as well as a central shaft sized for insertion into a metatarsal bone having a central shaft longitudinal axis, a central shaft proximal end coupled to the concave bone-facing surface of the articular member, and a central shaft distal end extending away from the concave bone-facing surface of the articular member along the central shaft longitudinal axis.

Implants, systems, instruments, methods, and kits for metatarsophalangeal joint arthroplasty may include metatarsal arthroplasty implants, repositioning guides, broach tools, inserter tools, and sterilizable packaging configured to facilitate metatarsal arthroplasty surgical procedures. The metatarsal arthroplasty implants may generally include an articular member having a convex articular surface, a concave bone-facing surface opposite the convex articular surface, and at least one side surface intermediate the convex articular surface and the concave bone-facing surface, as well as a central shaft sized for insertion into a metatarsal bone having a central shaft longitudinal axis, a central shaft proximal end coupled to the concave bone-facing surface of the articular member, and a central shaft distal end extending away from the concave bone-facing surface of the articular member along the central shaft longitudinal axis.

Implants, systems, instruments, methods, and kits for metatarsophalangeal joint arthroplasty may include metatarsal arthroplasty implants, repositioning guides, broach tools, inserter tools, and sterilizable packaging configured to facilitate metatarsal arthroplasty surgical procedures. The metatarsal arthroplasty implants may generally include an articular member having a convex articular surface, a concave bone-facing surface opposite the convex articular surface, and at least one side surface intermediate the convex articular surface and the concave bone-facing surface, as well as a central shaft sized for insertion into a metatarsal bone having a central shaft longitudinal axis, a central shaft proximal end coupled to the concave bone-facing surface of the articular member, and a central shaft distal end extending away from the concave bone-facing surface of the articular member along the central shaft longitudinal axis.

A method for ameliorating joint conditions and diseases and preventing bone hypertrophy can include facilitating cartilage regrowth and preventing bone overgrowth to a damaged bone at a treatment site within a body joint to promote healing. The method can include providing a device having a first section comprising a joint-ward end having an inner surface and an outer surface and fenestrations between the inner and outer surfaces. A second section can include an opposing leading end and a lateral wall extending between the joint-ward end and the leading end. The leading end can be penetrated into the bone to a depth to substantially position:1) the joint-ward end in a cartilage zone or at a boundary/transition area; and 2) the second section in the bone. Bone overgrowth into the cartilage zone may be prevented within the body joint when the device is positioned at the treatment site.

An implant for the replacement and regeneration of biological tissue in the shape of a plug, comprising a base section (2) configured for anchoring in bone tissue, a middle section (3) configured for replacing cartilage tissue, and a top section (4) configured for growing cartilage tissue onto and into, wherein the middle and top sections comprise the same thermoplastic elastomeric material, which is porous in the top section, and non-porous in the middle section, and wherein the base section comprises a substantially non-porous polyaryletherketone polymer with a porosity of less than 20%, relative to the total volume of the polyaryletherketone polymer.

A non-biodegradable implant for the replacement and regeneration of biological tissue in the shape of a plug, comprising a base section (2) configured for anchoring in bone tissue, a middle section (3) configured for replacing cartilage tissue of an intermediate and deep zone of the cartilage layer and having a thickness of at least 0.2 mm, and a top section (4) configured for growing cartilage tissue onto and into, thus regenerating a superficial zone of the cartilage layer, wherein the middle and top section comprise the same thermoplastic elastomeric material, which is porous in the top section, and non-porous in the middle section, wherein the thermoplastic elastomeric material comprises a linear block copolymer comprising urethane and urea groups, and is substantially free of an added peptide compound having cartilage regenerative properties, and wherein the base section material comprises one of a biocompatible metal, such as titanium or titanium alloy, ceramic, such as sintered crystalline hydroxylapatite, mineral, such as phosphate mineral, and polymer, optionally a hydrogel polymer, and combinations thereof.

This application describes an implantable device for tissue repair comprising at least two fabrics with interconnecting spacer elements transversing, connecting, and separating the fabrics, forming the device. Some embodiments have fixation points which can be an extension of at least one of the fabrics. The implantable device allows modification of the two fabrics having varying constructions, chemistries, and physical properties. The spacer elements create a space between the two fabrics, which can be used for the loading of biological materials (peptides, proteins, cells, tissues), offer compression resistance (i.e. stiffness), and compression recovery (i.e., return to original dimensions) following deformation and removal of deforming load. The inclusive fixation points of the fabrics are designed to allow for fine adjustment of the sizing and tension of the device to promote integration with the surrounding tissues as well as maximize the compressive resistance. The fixation points can include either the first fabric, the second fabric, or the combination of both fabrics. This device is suitable for soft and hard tissue regeneration or replacement with a preference for musculoskeletal tissues including but not limited to cartilage (including hyaline (referred to as articular; e.g. cartilage on the ends of long bones), fibrous (e.g. meniscus or intervertebral discs), elastic (e.g. ear, epiglottis)), bone, muscle, tendon, ligament, and fat.

A non-biodegradable plug-shaped implant (1) for the replacement and regeneration of biological tissue is described. The implant comprises a base section (2) configured for anchoring in bone tissue, and a top section (4) configured for growing cartilage tissue onto and into. The top section comprises a thermoplastic elastomeric material, which is porous. The thermoplastic elastomeric material comprises a linear block copolymer comprising urethane and urea groups, and may be substantially free of an added peptide compound having cartilage regenerative properties. The base section material further comprises one of a biocompatible metal, ceramic, mineral, such as phosphate mineral, and polymer, optionally a hydrogel polymer, and combinations thereof, wherein the thermoplastic elastomeric material further comprises carbonate groups.

A graft holder for securely transporting a graft, the graft holder including a base surface; and a cavity extended from the base surface and formed from one or more walls, the cavity configured so the graft is securely nested therewith when being transported between locations so as to minimize damage and/or impact to the graft during transport.

A graft or construct including an isolated cartilage chondrocytes from young donors (<20 years), seeded on a three-dimensional membrane composed of one of the main chondrogenesis-promoting substances (hyaluronic acid), in high densities (1×106) with autologous serum and sealed with a fibrin adhesive for the treatment of a cartilage lesion, with tissue formation that has greater durability, at a lower cost and with fewer risks than the treatments currently available for the management of such lesions. Likewise, a procedure for the treatment of articular cartilage lesions is provided, through the implantation of allogeneic chondrocyte grafts that present the capacity to generate or repair satisfactorily the cartilage of the lesion.