One embodiment of the present invention is directed to compositions and methods for enhancing attachment of soft tissues to a metal prosthetic device. In one embodiment a construct is provided comprising a metal implant having a porous metal region, wherein said porous region exhibits a nano-textured surface.

A bone implant includes (a) a first layer provided over a first outer surface of the bone implant and being formed of a first material which is one of water-soluble and degradable in body fluids, the first layer having a first thickness and (b) a second layer provided over an outer periphery of the first layer and being formed of a biocompatible material, the second layer having a second thickness smaller than the first thickness.

An implant includes a body including a substrate and a bone interfacing lattice disposed on the substrate. The bone interfacing lattice includes at least two layers of elongate curved structural members. In addition, the at least two layers of elongate curved structural members include a first layer adjacent the substrate and a second layer adjacent the first layer. Also, the first layer has a first deformability and the second layer has a second deformability, wherein the second deformability is greater than the first deformability.

Disclosed herein are methods and devices for repairing a knee joint, including customizable and/or highly selectable implants and/or implant components for each patient to provide optimal fit and function.

One embodiment of the present invention is directed to compositions and methods for enhancing attachment of soft tissues to a metal prosthetic device. In one embodiment a construct is provided comprising a metal implant having a porous metal region, wherein said porous region exhibits a nano-textured surface.

A medical implant for cartilage and/or bone repair at an articulating surface of a joint includes a contoured implant body and at least one extending post. The implant body has an articulating surface configured to face the articulating part of the joint and a bone contact surface configured to face the bone structure of a joint, where the articulating and bone contact surfaces face mutually opposite directions and the bone contact surface is provided with the extending post. A cartilage contact surface connects the articulating and the bone contact surfaces and is configured to contact the cartilage surrounding the implant body in a joint. The articulating surface has a layer that is a wear-resistant material. The cartilage contact surface has a coating that is a bioactive material.

To provide a bioimplant capable of controlling a rate of an antibacterial agent and an antibiotic to be eluted from the coating film. An evanescent coating film made of a calcium phosphate-based material having crystallinity of 90% or less is formed at a predetermined area of the bioimplant and an antibacterial agent or an antibiotic is contained in the coating film. If necessary, a metal oxide layer made of a metal oxide having an isoelectric point of less than 7 is formed on the bioimplant thereby suppressing adhesion of bacteria.

The present disclosure pertains to ankle prostheses. In an example embodiment, the ankle prosthesis comprises an adjustable and replaceable intermediate implant that is disposed between a tibial implant and a talar implant. The intermediate implant is adjustable relative to the tibial implant and can be interlocked therewith once adjusted. Methods of using, fitting, and adjusting the device are also described. Still other embodiments are described.

One embodiment of the present invention is directed to compositions and methods for enhancing attachment of soft tissues to a metal prosthetic device. In one embodiment a construct is provided comprising a metal implant having a porous metal region, wherein said porous region exhibits a nano-textured surface.

An implant has an implant surface of layered coatings. A method of manufacturing is for an implant having an implant surface. The implant having an implant surface has a micro-pattern layer on the implant surface made by micro-machining, and a primary component layer deposited over the micro-pattern layer that promotes bio-integration of the implant. The micro-pattern layer has micro-trenches in predefined dimensions and arranged in a periodic array.