Methods and compositions for the biological repair of cartilage using a hybrid construct combining both an inert structure and living core are described. The inert structure is intended to act not only as a delivery system to feed and grow a living core component, but also as an inducer of cell differentiation. The inert structure comprises concentric internal and external and inflatable/expandable balloon-like bio-polymers. The living core comprises the cell-matrix construct comprised of HDFs, for example, seeded in a scaffold. The method comprises surgically removing a damaged cartilage from a patient and inserting the hybrid construct into the cavity generated after the foregoing surgical intervention. The balloons of the inert structure are successively inflated within the target area, such as a joint, for example. Also disclosed herein are methods for growing and differentiating human fibroblasts into chondrocyte-like cells via mechanical strain.

An improved modular rotational device includes a first and second threaded coupler for affixation along the stem of an endoprosthetic device, for example, a humeral prosthesis or a femoral prosthesis. The rotational device axis of rotation is coaxial with the stem, and its axis of rotation is located in close proximity to the intramedullary stem of the prosthesis or in close proximity to the distal articulation of the prosthesis. A housing has a proximal and distal end with an axial bore therethrough for receiving an elongated stem of the device. A lobe ring may be utilized to limit the axis of rotation of the device. Additional endoprosthetic devices may be attached to male or female threaded couplers, or to Morse tapers. A plurality of suture attachments facilitates attachment of soft tissue thereto.

A compression fastener may include a shaft and a helical thread disposed about the shaft. The shaft may include a proximal end, a distal end, a proximal shaft portion, and a distal shaft portion. The helical thread may include at least one concave undercut surface and a plurality of pitches that may include at least one first pitch along the proximal shaft portion and at least one second pitch along the distal shaft portion. The at least one concave undercut surface may be angled towards one of the proximal end and the distal end of the shaft, and the at least one first pitch and the at least one second pitch may not be equal to each other.

The invention relates to a connecting sleeve for anchoring shafts of two oppositely arranged prostheses, preferably on an elongate bone such as a femur or humerus. The reinforcing sleeve comprises two receiving bushes for one prosthesis shaft each and comprises a separable coupling region arranged therebetween for connection in such a manner as to resist shear forces and rotation. According to the invention, each receiving bush has, on the side thereof facing the coupling region, one fork of a pair of forks that interact with each other, and a fitting block is arranged on a base of the fork, the lateral surfaces of which fitting block have a distance that corresponds to an inner width of the fork, and the lateral surfaces are designed to contact flanks of the fork in a planar manner, at least one fastening screw being arranged transversely through the fork. The fork connection is simpler to produce than the known wedge connection and yet is sufficiently robust. Unlike in the case of the wedge connection, an exact fit is not required; a clearance fit between the fork and the fitting block is sufficient in principle, excessive play being eliminated by means of the fastening screw.

The present invention relates to a spacer device including a sensor as well as electronic means for obtaining and transmitting the data detected by the sensor.

The present disclosure pertains to ionic polymer compositions, including semi.- and fully interpenetrating polymer networks, methods of making, such ionic polymer compositions, articles made from such ionic polymer compositions, and methods of making such articles and packaging, for such articles.

An artificial joint is characterized by: having a first member including a caput part on which a prescribed curved surface is formed, and a second member including a fossa part having a surface which abuts the prescribed curved surface of the caput part; the second member being rotatable in a flexing direction of a joint with a prescribed point on the caput part being the center of rotation; and the prescribed curved surface of the caput part being defined by a curve which depicts a convex arc toward the side abutting the fossa part when the caput part is viewed from the axial direction of the rotation, and in which, when two arbitrary points are taken on the curve, the radius of curvature of the point positioned further toward the flexing side of the joint on the curve is smaller than the radius of curvature of the other point.

A bone implant may include a shaft having a proximal end, a distal end, a longitudinal axis, a proximal shaft portion, and a distal shaft portion. The proximal shaft portion may include a first minor diameter, and a first helical thread disposed about the proximal shaft portion defining a first major diameter. The first helical thread may include a first concave undercut surface. The distal shaft portion may include a second minor diameter, and a second helical thread disposed about the distal shaft portion defining a second major diameter. The second helical thread may include a second concave undercut surface. The first and second concave undercut surfaces may be angled towards the distal end of the shaft. The second minor diameter may be smaller than the first minor diameter and the second major diameter may be smaller than the first major diameter.

A method of preventing bone blowout may include forming a hole in a bone, the hole having a bone hole diameter, and inserting a bone fastener into the hole. The bone fastener may include a shaft having a minor diameter and a helical thread. The helical thread may be disposed about the shaft and may include a first undercut surface and a second undercut surface. The first undercut surface may be angled toward one of the proximal end and the distal end of the shaft, and the second undercut surface may be angled toward the other one of the proximal end and the distal end of the shaft. The minor diameter of the shaft may not be greater than 5% larger the bone hole diameter.

A pedicle bone fastener may include a shaft, a helical thread, and an integrated attachment feature. The shaft may include a proximal end, a distal end, and a longitudinal axis. The helical thread may be disposed about the shaft along the longitudinal axis between the proximal and distal ends of the shaft. The helical thread may include a first undercut surface and a second undercut surface. The first undercut surface may be angled toward one of the proximal end and the distal end of the shaft and the second undercut surface may be angled toward the other one of the proximal end and the distal end of the shaft. The integrated attachment feature may be disposed at the proximal end of the shaft and configured to be adjustably secured to a spinal stabilization implement.