Placement apparatus and methods of use for impanation of spacers within an inter-vertebral disc space. In one embodiment, the load-bearing superstructure of the implant is subdivided and the bone forming material is positioned within an internal space of the placement instrument but external to the load bearing elements themselves. At least a portion of the bone graft material is freely contained within the disc space. A method of using the device is also described. In one embodiment, the placement device is used to place the implantable spacers at opposing ends of the disc space using a directly lateral surgical approach.

A mesh implant and/or container may be used as an intervertebral implant. The mesh implant may be anchored or otherwise fixed to the vertebral endplates to prevent the implant from migrating forward and out anteriorly to the spinal column. The mesh implant may be knitted with a rip stop, elastic or other stich pattern to prevent unraveling or tearing.

An organ implant, such as a heart implant, including a support structure having a plurality of pores and defining passages configured for the growth of blood vessels; and stem cells from at least one soft tissue source of a patient deposited into the pores of the support structure is described. The implant is configured to repair a portion of an organ of the patient.

Apparatus and associated methods relate to a balloon kyphoplasty surgical device comprising an extrusion tube having internal fluid channels and a support wire, a port arrangement positioned on a proximal end of the extrusion tube and a balloon arrangement positioned on a distal end of the extrusion tube, the balloon arrangement resulting in a cubic shape when inflated by the port arrangement. An exemplary implementation may be configured with multiple inner balloons housed in an outer balloon to create a specific shape. Some designs may be configured with multiple ports designed to individually and independently inflate each inner balloon and outer balloon. The outer balloon may be inflatable. The outer balloon may be sealed off, constraining inflation of the inner balloons to create a cubic-like shape when the inner balloons are inflated within the sealed outer balloon, resulting in improved vertebral structure stabilization by increased surface area lifting the bone.

A bone screw fixation system includes a bone screw body having a screw head at one end of the screw and a screw tip at an opposite end of the screw, the screw head having an internal complex geometric shaped drive and internal threads within the screw head; and a screw inserter compatible with the screw head and having a complex geometric shaped drive configured to matingly engage the internal complex geometric shaped drive of the screw head and a threaded tip configured to thread into the internal threads of the screw head.

A bone graft generation and delivery process can include inserting bone material into an impactor system. The process can include processing, via the impactor system, the bone material into bone graft material. Processing the bone material can include milling the bone material via a first rotational element of the impactor system. Processing the bone material can include cutting the bone material via a second rotational element of the impactor system. Processing the material can include filtering the cut and milled bone material to isolate bone graft material. The process can include delivering, via the impactor system, the bone graft material to a target site.

The present disclosure relates to a system, apparatus and method for near-simultaneous and integrated delivery of bone graft material during the placement of surgical cages or other medical implants in a patient's spine. The integrated fusion cage and graft delivery device according to various embodiments delivers and disperses biologic material through a fusion cage to a disc space and, without withdrawal from the surgical site, may selectively detach the fusion cage for deposit to the same disc space. The integrated fusion cage and graft delivery device is formed such that a hollow tube and plunger selectively and controllably place bone graft material and a fusion cage in or adjacent to the bone graft receiving area. The system also includes a cover plate that secures to the fusion cage.

A spinal fixation system includes an expandable disc replacement body and an angle-setting disc replacement holder; The expandable disc replacement body includes a first wall, a second wall, and a hinge connecting the first wall and the second wall. An insertion instrument may be used to implant the expandable disc replacement body into a subject. The disc replacement holder is positioned between the first wall and the second wall, and an angle and/or height between the first wall and the second wall can be varied by adjustment of the disc replacement holder and locked into place using locking mechanisms.

A graft compression system for compressing soft tissue grafts used in connection with reconstructive surgery on the anterior cruciate ligament (ACL). The graft compression system includes a compression chamber having an elongate hollow shaft body having two ends that are threaded to mate with correspondingly threaded collet nuts. Collets are removably inserted into, and engage, the collet nuts fastened to opposing ends of the compression chamber A surgical graft may be inserted into a hollow compression tube having a lumen with a compressible diameter, said compression tube being sized for insertion into the collets and compression chamber. When such collet nuts are tightened by a user of the graft compression system, the inner diameters of the respective collet nuts nested within such collet nuts are decreased, causing the diameter of the lumen of the hollow compression tube to in turn be decreased and compress the surgical graft within.

The invention concerns a bone graft material for use in a spinal fusion method, wherein the material comprises i) a composition for forming a matrix, comprising at least a first matrix material precursor component and a second matrix material precursor component, capable of forming a matrix by crosslinking of the precursor components under appropriate conditions; and ii) a bioactive factor, which is biologically active to stimulate bone formation between two vertebrae, and for effecting or supporting spinal fusion; wherein the spinal fusion method comprises the steps of applying a cage in between the two vertebrae, which is not pre-filled with the bone graft material; and subsequently applying the bone graft material adjacent to and/or into the cage, such that essentially the entire remaining volume between the two vertebrae is filled with the bone graft material. The invention allows for ease of use while forming a more homogeneous matrix.