Systems are described for stabilizing a dysfunctional sacroiliac (SI) joint of a subject. The systems include a tool assembly and a defect creation assembly, and a prosthesis. The tool assembly is adapted to create a pilot SI joint opening in the dysfunctional SI joint; portions of which being disposed in the sacrum and ilium bone structures. The prosthesis is sized and configured to be press-fit into the pilot SI joint opening, wherein the pilot SI joint opening transitions to a larger post-prosthesis insertion SI joint opening and the prosthesis is securely engaged to the sacrum and ilium bone structures. The system optionally includes an image capture apparatus adapted to capture images reflecting positions and/or orientations of the tool assembly when disposed in the subject's body.

A novel method and instrumentation for insertion of humeral and glenoid total shoulder implant using arthroscopic visualization for bony preparation as well as insertion of components through small incisions. Mini instruments and cannulated guides and reamers are used in order to perform the procedure under direct arthroscopic visualization. For ease of insertion, the components are inserted separately and assembled in situ. Securing the humeral components in place is accomplished with bicortical screw transfixing the central peg of component. Also disclosed are components, parts thereof and instruments used therewith.

A bone structural device including a plurality of bone structural segments, wherein adjacent bone structural segments are pivotally connected to one another about a pivot axis, and the bone structural segments are expandable in height, which is in a direction generally parallel to the pivot axis.

An access device for accessing an intervertebral disc having an outer shield comprising an access shield with a larger diameter (˜16-30 mm) that reaches from the skin down to the facet line, with an inner shield having a second smaller diameter (˜5-12 mm) extending past the access shield and reaches down to the disc level. This combines the benefits of the direct visual microsurgical/mini open approaches and the percutaneous, “ultra-MIS” techniques.

Expandable fusion devices, systems, instruments, and methods thereof. The expandable fusion implant may include an upper endplate assembly and a lower endplate assembly. The upper and lower endplate assemblies may be configured to expand in width. A rotatable actuator may move one or more driving ramps, which mate with an upper ramp and a lower ramp, respectively. The actuator may cause independent movement of one or more of the driving ramps, thereby causing an expansion in height of the upper and lower endplate assemblies.

Apparatus for attaching a first object to a second object, said apparatus comprising: a distal anchor comprising a generally cylindrical body, a distal end and a proximal end, wherein said distal end comprises an inclined distal end surface, and a vertical bore extending through said generally cylindrical body, perpendicular to the longitudinal axis of said generally cylindrical body; a distal suture having a proximal end and a distal end, with an enlargement formed at said distal end and an eyelet formed at said proximal end, wherein said suture extends through said vertical bore of said distal anchor; a proximal anchor comprising a generally cylindrical body, a distal end and a proximal end, a vertical bore extending through said generally cylindrical body, perpendicular to the longitudinal axis of said generally cylindrical body, a recess formed on one side of said generally cylindrical body and a U-shaped slot formed on the opposing side of said generally cylindrical body, whereby to form a flexible finger extending distally within said generally cylindrical body, and further wherein said distal end of said finger is spaced from an opposing portion of said generally cylindrical body; and a proximal suture having a proximal end and a distal end, with an enlargement formed at said distal end, wherein said proximal suture extends through said vertical bore of said proximal anchor, through said eyelet of said distal suture, back through said vertical bore of said proximal anchor, through said recess of said proximal bore and through said U-shaped slot of said proximal anchor, with a loop of proximal suture extending through said eyelet of said distal suture.

A bone joint spacer has two endplates which have a bone engaging surface on one side, and ramps extending from an opposite side. A shaft has a threaded end, and another end which has ramp followers which mate with the endplate ramps of both endplates. A collar slides over the threaded end of the shaft, and also has ramp followers which mate with the endplate ramps of both endplates. A nut threads onto the end of the shaft and pushes the collar towards the ramp followers of the shaft. This movement causes the ramp followers to slide the ramp followers of the collar and the shaft against the endplate ramps, pushing the endplates apart. Two of these spacers can be combined by a link plate so that the spacers can be aligned or curved into a U-shape to be inserted into the body and positioned between bony surfaces, respectively.

Methods, compositions, and systems are provided for characterization of modified nucleic acids. In certain preferred embodiments, single molecule sequencing methods are provided for identification of modified nucleotides within nucleic acid sequences. Modifications detectable by the methods provided herein include chemically modified bases, enzymatically modified bases, abasic sites, non-natural bases, secondary structures, and agents bound to a template nucleic acid.

Surgical visualization systems and related methods are disclosed herein, e.g., for providing visualization during surgical procedures. Systems and methods herein can be used in a wide range of surgical procedures, including spinal surgeries such as minimally-invasive fusion or discectomy procedures. Systems and methods herein can include various features for enhancing end user experience, improving clinical outcomes, or reducing the invasiveness of a surgery. Exemplary features can include access port integration, hands-free operation, active and/or passive lens cleaning, adjustable camera depth, and many others.

A prosthesis including a hemiarthroplasty cup including an inner surface shaped and sized to accommodate a reamed or unreamed femoral head outer surface, and an outer surface shaped and sized to accommodate a reamed or unreamed acetabulum outer surface of an acetabulum socket, wherein the hemiarthroplasty cup is configured to maintain allowance of articulation of the femoral head outer surface and the acetabulum socket relative to the hemiarthroplasty cup after implantation.