The present invention is directed to methods for collecting and processing autografts, processed autografts, kits for collecting and transporting autografts, and tools for preparing autografts. It is also directed to autologous bone grafts, and methods of preparing them.

A tissue treatment apparatus and method for treating bone tissue has a controller, an enclosure, a reagent supply system, a draining configuration, and a gas relief valve is controlled by the controller. A bioactive agent may be applied through the reagent supply system. Optionally provided is a gas evacuation assembly, a gas supply unit, a thermal unit for heating or cooling reagents or gases, a sonication unit, any or each operated by the controller. The method provides for programming controller to effect a treatment procedure. In an embodiment of the present application the treatment procedure effects demineralization of the bone material.

A method of recovering progenitor cells from bone marrow aspirate. A bone void filler preparation container is provided. The bone void filler preparation container has an inlet port and an outlet port. A bone graft matrix having a particle size of between about 1,000 m and about 2,000 m is placed in the bone void filler preparation container. A bone marrow aspirate is passed through the bone void filler preparation container. Progenitor cells in the bone marrow aspirate are retained in the bone void filler preparation container. Greater than about 83 percent of the progenitor cells in the bone marrow aspirate are retained in the bone void filler preparation container.

A device for loading bone graft material into a delivery tube is provided herein. The device includes a housing defining a reservoir for receiving bone graft, a magazine at least partially disposed within the housing, and an actuation member coupled to the housing for discharging the bone graft material into the delivery tube. The magazine defines a first chamber and a second chamber and is moveable between a first position in which the first chamber is in communication with the reservoir and a second position in which the second chamber is in communication with the reservoir. The actuation member includes a plunger configured to slide into the first chamber and the second chamber to discharge bone graft material, when bone graft material is contained therein, into the delivery tube. Methods of loading bone graft material are also provided.

A bone cutting assembly includes a manually actuated upper cutting element that carries a plurality of cutting blades configured to cut through frozen bone segments. A lower cutting element supports a bone segment to be cut and can include cutting blades aligned with the cutting blades of the upper cutting assembly. A pivoting linkage or a rack and pinion arrangement can be provided between the upper cutting element and a manually operated handle to provide sufficient mechanical advantage or leverage to allow an operator to manually cut through the bone.

The present invention is directed to an adherent resorbable matrix for use in surgical applications. The adherent resorbable matrix includes a biocompatible adherent material including chitosan.

Described herein is a method of preparing a bone graft product, comprising computer-guided precision cutting an unshaped piece of bone from a human cadaver or a bovine animal to provide a shaped piece of bone having a predetermined shape that is determined by a human being using computer-aided design. Bone graft products prepared using this method and methods of grafting these products are also disclosed.

Tools, devices and systems that include a generally cylindrical, hollow shaft, and a suction canister are provided with advantageous interconnectivity features and functions that enable ease of manufacturing, lowered manufacturing costs, and allow for a platform of different shaft embodiments and canister embodiments that may be manufactured in different combinations to form an array of unique instruments. The interconnectivity may be irreversible or reversible, and the connection features maintain an air tight seal between the components. Tools, devices and systems are also provided that include collection functionality that can be employed to manipulate the volume of tissue collected while using a tissue collection feature/function. This may be undertaken to restrict total volume of the collection chamber in a way that allows for continuous suction flow rate to take place while collecting the desired amount of tissue. Containing the tissue to a pre-set volume can enable a user to effectively ascertain the volume of tissue collected.

An apparatus for transforming teeth into bone material, which is suitable to treat the teeth by immersion in liquids and includes a reactor device including a contactor, a reaction chamber, an ejection chamber, a cartridge including a plurality of containers for the processing and washing liquids, separated liquid-tight from each other, a fragmentation device suitable to fragment teeth, a guide suitable to detachably connect the cartridge and the fragmentation device to the apparatus, and a movement device suitable to detachably connect at least partially the reactor device and allow it to sequentially withdraw the teeth from the fragmentation device and the liquids from the cartridge.

The present invention is directed to a fiber, preferably bone fiber, having a textured surface, which acts as an effective binding substrate for bone-forming cells and for the induction or promotion of new bone growth by bone-forming cells, which bind to the fiber. Methods of using the bone fibers to induce or promote new bone growth and bone material compositions comprising the bone fibers are also described. The invention further relates to a substrate cutter device and cutter, which are effective in producing substrate fibers, such as bone fibers.