Disclosed are various bioactive grafts and methods of making the same. In one embodiment, bone material is harvested from a donor. The harvested bone material is exposed to a lysing agent, the lysing agent configured to release growth factors and bioactive materials from cellular material of the harvested bone material. The harvested bone material is then rinsed with a rinsing agent. The pH of the harvested bone material is substantially neutralized.

This disclosure relates to planning systems, methods and instrumentation. The planning systems, methods and instrumentation disclosed herein may be utilized for planning orthopaedic procedures to restore functionality to a joint, may include determining an amount of bone loss along or otherwise adjacent to an articular surface of a bone. Instrumentation may be formed based on one or more dimensions associated with the bone loss. The articular surface may be repaired, which may include utilizing the instrumentation and planning systems to position and secure a bone graft along a position of the bone associated with the bone loss.

A bone grinder is provided herein. The bone grinder may have a grinding chamber, an intermediate zone, and a primary cutting element and a secondary cutting element. The intermediate zone may have a first wall and a second wall within the grinding chamber, and the intermediate zone may separate the primary cutting element from the secondary cutting element. The first wall and the second wall may slope inward such that a distance between the first wall and the second wall generally decreases from the primary cutting element to the secondary cutting element. The primary cutting element and the secondary cutting element may be positioned within the grinding chamber to sequentially perform primary cutting operations and secondary cutting operations on a bone. A drive mechanism may operatively engage the primary cutting element and the secondary cutting element.

There is disclosed a system and methods for debriding soft tissue from bone using a high-pressure water debridement system. One embodiment includes a cylindrical sleeve bounded by endcaps and having a drainage port positioned for effluent drainage. A central shaft is configured to receive a bone segment and is disposed along a longitudinal center of the sleeve and rotatively coupled between the endcaps. At least one high-pressure water nozzle is disposed on each side of the sleeve, each of which is positioned to impact the bone segment with a high-pressure water stream. A rotational actuator is configured to rotate the central shaft and the bone segment relative to the sleeve and the water nozzles such that when the high-pressure water nozzles are operational, the high-pressure water streams debride the bone segment. Other embodiments are also disclosed.

A bone graft generation and delivery process can include inserting bone material into an impactor system. The process can include processing, via the impactor system, the bone material into bone graft material. Processing the bone material can include milling the bone material via a first rotational element of the impactor system. Processing the bone material can include cutting the bone material via a second rotational element of the impactor system. Processing the material can include filtering the cut and milled bone material to isolate bone graft material. The process can include delivering, via the impactor system, the bone graft material to a target site.

Coated bone grafts are provided as well as methods of use thereof and methods of making. In accordance with the instant invention, methods of preparing a coated bone graft (e.g., bone allograft) are provided. In certain embodiments, the method comprises electrospraying a composition comprising a polymer and, optionally, an agent, particularly a therapeutic agent, onto the surface of the bone graft. Therapeutic agents include, without limitation: bone stimulating agents, anti-fibrotic agents, antimicrobials, anti-inflammatory agents, and pro-angiogenesis agents.

Described are fibula malleolus caps and surgery devices with fibula malleolus caps. The fibula malleolus caps may be patient-specific fibula malleolus caps. The devices with patient-specific fibula malleolus caps overcome the sliding and rotational errors during fibula flap harvesting. A comparative clinical study demonstrates that the fibula malleolus cap enhances the accuracy of fibula flap harvesting, leading to accurate location and angulation of simultaneous dental implants.

The present invention is directed to methods for collecting and processing autografts, processed autografts, kits for collecting and transporting autografts, and tools for preparing autografts. It is also directed to autologous bone grafts, and methods of preparing them.

The invention concerns a bone graft material for use in a spinal fusion method, wherein the material comprises i) a composition for forming a matrix, comprising at least a first matrix material precursor component and a second matrix material precursor component, capable of forming a matrix by crosslinking of the precursor components under appropriate conditions; and ii) a bioactive factor, which is biologically active to stimulate bone formation between two vertebrae, and for effecting or supporting spinal fusion; wherein the spinal fusion method comprises the steps of applying a cage in between the two vertebrae, which is not pre-filled with the bone graft material; and subsequently applying the bone graft material adjacent to and/or into the cage, such that essentially the entire remaining volume between the two vertebrae is filled with the bone graft material. The invention allows for ease of use while forming a more homogeneous matrix.

A bone plug compression instrument that can be used to reshape includes a first compression element having a first cavity, a second compression element having a second cavity, and a base portion for supporting the first and second compression elements. The second compression element moves between first and second positions. In the first position, the bone plug compression instrument forms an open configuration, in which the first and second cavities are spaced apart from each other allowing the bone plug in a substantially non-compressed state to be inserted in a space between the first and second cavities In the second position, the bone plug compression instrument forms a closed configuration, in which the first and second cavities press against each other to form a combined cavity for compressing the bone plug received in the combined cavity. The combined cavity has at least a partially converging shape.