A workstation having a pair of posts on either side of a clamping plate where a donor bone may be placed on sequentially cut in three separate cutting paths. Cutting gates are attached to the posts and used to provide cutting paths that can be precisely oriented with respect to the meniscus of the donor bone part using visual alignment without any manual measurements. The graft is affixed to a machining clamp and shaved to appropriately shape the sides and form a radius on the bottom of the graft. A tibia is then prepared by using a drill guide to form a pilot hole and then to drill out a large hole for the graft. The drilled hole is expanded and shaped using a rod guide and chisel and then a rasp. The shaped graft may then be implanted into the shaped hole and sutured in place.

A bone graft containment device includes a body extending longitudinally from a first end to a second end. The body is defined via a strut framework sized and shaped to correspond to an outer surface of a target bone. The strut framework defines an interior space configured to receive a bone graft or bone graft substitute material. The device also includes a first grasping structure and a second grasping structure extending from an exterior of the body. The first and second grasping structures are configured to receive a bone fixation plate therebetween.

The present invention is directed to a fiber, preferably bone fiber, having a textured surface, which acts as an effective binding substrate for bone-forming cells and for the induction or promotion of new bone growth by bone-forming cells, which bind to the fiber. Methods of using the bone fibers to induce or promote new bone growth and bone material compositions comprising the bone fibers are also described. The invention further relates to a substrate cutter device and cutter, which are effective in producing substrate fibers, such as bone fibers.

The invention provides a plasticized tissue or organ that does not require special conditions of storage, for example refrigeration or freezing, exhibits materials properties that approximate those properties present in natural tissue, is not brittle, does not necessitate rehydration prior to clinical implantation and is not a potential source for disease transmission. Replacement of the chemical plasticizers by water prior to implantation is not required and thus, the plasticized bone or soft tissue product can be placed directly into an implant site without significant preparation in the operating room.

This invention is directed to an assembled implant comprising two or more portions of bone that are held together in appropriate juxtaposition with one or more biocompatible pins to form a graft unit. Preferably, the pins are cortical bone pins. Typically, the cortical pins are press-fitted into appropriately sized holes in the bone portions to achieve an interference fit. The bone portions are allograft or xenograft.

A method of denuding bone stock with a denuder, such as a bone stock denuder container, is disclosed. The bone stock is deposited into a wash chamber formed with a curved chamber wall. The bone stock is impacted with a stream of fluid under pressure to separate non-bone tissue from bone. Fluid and non-bone tissue are drained from the wash chamber.

This disclosure relates to methods of mineralizing cell-laden matrices. Disclosed herein are cell-laden matrix compositions. Also disclosed herein are methods of selectively mineralizing a cell-laden matrix. Methods of culturing biomimetic bone tissue are disclosed herein. Also disclosed herein are kits containing compositions disclosed herein or portions thereof.

A bone graft containment device includes a body extending longitudinally from a first end to a second end. The body is defined via a strut framework sized and shaped to correspond to an outer surface of a target bone. The strut framework defines an interior space configured to receive a bone graft or bone graft substitute material. The device also includes a first grasping structure and a second grasping structure extending from an exterior of the body. The first and second grasping structures are configured to receive a bone fixation plate therebetween.

The invention provides a method of making a biological disc graft. In one embodiment, the biological disc graft is useful for treating back or neck pain. In one embodiment, the biological disc graft is useful for treating any joint pain. The invention also provides a method of implanting said biological disc graft in a way that is minimally invasive and less dangerous.

A system for improving graft harvesting is disclosed including a tendon harvesting instrument for producing a graft from a tendon. The instrument includes a handle, a shaft and a blade portion operatively coupled to the shaft. The blade portion defines a cutting edge that at least partially corresponds to the shape of a graft cross section of the graft. The blade portion is inserted into the tendon by axially rotating the instrument shaft. The blade portion may include a free end for piercing the tendon as the blade portion is rotated into the tendon. The harvesting instrument may also include amputating means for removing the end connection of the graft to the tendon, the amputating means including a means of changing an orientation of an end portion of the cutting edge.