A stent assembly (42) adapted for endoluminal placement by endovascular deployment for the treatment of a false lumen (10) associated with a vascular dissection. The stent assembly has a number of self expanding stents (35) connected together to define an elongate substantially cylindrical lumen wall engaging surface. The stents are adapted to provided pressure on the wall of the lumen adjacent to and extending away from a rupture. A deployment device (40) for the stent assembly includes a sheath (48) and a retention and release arrangement (50) to retain the proximal end (37) of the stent graft to the deployment device. Release of the stent assembly is by withdrawal of the sheath before release of its proximal end by the use of a trigger wire (54) of the retention and release arrangement.

A device for placement in the aortic arch of a patient is provided. The device includes a distal portion for being engageably received in an aortic arch of a patient beyond the left subclavian artery and a stent portion fluidly engaged with the distal portion, the stent portion being permeable and configured to span a portion of the aortic arches to which the brachiocephalic trunk, left common carotid artery, and left subclavian artery attach to the aortic arch. A diameter of the stent portion may be modified by translation of the proximal portion to thereby alter a length of the stent portion thus causing modification of the diameter of the stent portion to fit anatomical features of differing dimensions.

A method and an assembly for securing a crimped medical device over a deflated balloon of a balloon catheter is provided. The medical device is positioned in its expanded state over the deflated balloon of the balloon catheter, and is then crimped over the deflated balloon. First and second eyelets of first and second strings, respectively, are then threaded through first and second rings, respectively, that are provided on the medical device. Next, a locking wire is advanced through a lumen defined between the sheath and the catheter body to exit the distal end of the sheath, and then advanced through the first and second eyelets and into the distal tip of the balloon catheter. The sheath is then advanced over the crimped medical device to the distal tip to completely cover the crimped medical device.

An elongate delivery shaft assembly (30) includes an outer covering shaft (38) and an inner support shaft (40). When the delivery shaft assembly (30) is unconstrained and a stent-graft (20) is removably constrained in a radially-compressed delivery state along a distal end portion (34) of the delivery shaft assembly (30), radially between the outer covering shaft (38) and the inner support shaft (40): (a) the delivery shaft assembly (30) is shaped so as to define a self-orienting portion (50), which (i) is shaped so as to define at least proximal and distal curved portions (52A, 52B), the proximal curved portion (52A) disposed more proximal than the distal curved portion (52B), and (ii) at least one point of inflection (53) on a central longitudinal axis (36) of the delivery shaft assembly (30) longitudinally between the proximal and the distal curved portions (52A, 52B), and (b) respective smallest radii of curvature of the proximal and the distal curved portions (52A, 52B), measured at the central longitudinal axis (36), are each between 2.5 and 12 cm.

A stent graft delivery system includes a handle, a guidewire catheter extending distally from the handle, at least one tube, and at least one wire extending through the at least one tube, wherein each wire of the stent graft delivery system is configured as a loop at the distal end of the tube. The stent graft delivery system can be employed to implant stent grafts in a patient to thereby treat, for example, an aortic aneurysm spanning a region of an aorta that includes at least one arterial branch.

A stent graft delivery system includes a handle, a guidewire catheter extending distally from the handle, at least one tube, and at least one wire extending through the at least one tube, wherein each wire of the stent graft delivery system is configured as a loop at the distal end of the tube. The stent graft delivery system can be employed to implant stent grafts in a patient to thereby treat, for example, an aortic aneurysm spanning a region of an aorta that includes at least one arterial branch.

Various aspects of the present disclosure are directed toward apparatuses, systems, and methods that include an implantable medical device and a constraining line conduit arranged around a circumference of the implantable medical device. The apparatuses, systems, and methods may also include a constraining line arranged through the constraining line conduit.

An implantable medical device for closure of a tissue tract/opening in a vessel wall includes a constraint disposed around and constraining the implantable medical device in a constrained configuration and one or more deployment lines attached to the constraint. A flexible hollow body is coupled proximate a midpoint of the implantable medical device. The implantable medical device and flexible hollow body are operable to transition (pivot) from a parallel, side-by-side arrangement to be substantially angled relative to one another. Retracting the one or more deployment lines causes the constraint to release the implantable medical device to transition from the constrained configuration to an expanded configuration.

Various aspects of the present disclosure are directed toward apparatuses, systems, and methods that include an implantable medical device and a constraining line conduit arranged around a circumference of the implantable medical device. The apparatuses, systems, and methods may also include a constraining line arranged through the constraining line conduit.

Apparatus and methods are described including implanting an aortic pressure-loss-reduction device in a subject's ascending aorta. A frame of the device includes a first set of sinusoidal struts disposed between a downstream end of an upstream anchor and an upstream end of the intermediate portion, the sinusoidal struts being shaped to form a folded portion between the downstream end of the upstream anchor and the upstream end of the intermediate portion. The frame includes a second set of sinusoidal struts disposed between an upstream end of a downstream anchor and a downstream end of the intermediate portion, the sinusoidal struts being shaped to form a folded portion between the upstream end of the downstream anchor and the downstream end of the intermediate portion. Other applications are also described.