A gastrointestinal device for treating obesity includes a three-dimensional porous structure configurable between a compressed pre-deployment configuration to facilitate delivery and an expanded post-deployment configuration. The porous structure includes a first opening at its proximal end and a larger second opening at its distal end. The porous structure also includes a sleeve coupled to its distal end. Optionally, the device further includes a suture at the proximal end of the wire mesh structure to facilitate retrieval and an anti-migration component positioned at the junction of the porous structure with the sleeve. The porous structure is deployed in a patient's stomach such that the anti-migration component sits proximal to the patient's pylorus and prevents migration of the entirety of the device into and through the pylorus. The sleeve extends through the pylorus, into the duodenum and ends in the duodenum or jejunum. Food enters the device from the first opening at the proximal end of the porous structure, passes through the porous structure and sleeve, and exits at the distal end of the sleeve. The device treats obesity by providing a relatively immovable volume occupying structure in the stomach and a bypass for food past the pylorus and proximal portion of the small intestine. Optionally, the device further acts to slow the passage of food through the digestive tract. Patients with the device experience satiety more quickly and have a prolonged sensation of satiety.

A surgical instrument (100) for placement of a movement restriction device (10) for use in a surgical procedure for treating reflux disease in a patient. The instrument comprises a sleeve (113) and a holding device (111) configured to engage the movement restriction device, wherein the holding device is configured to be placed within the sleeve and be displaceable in relation to the sleeve. The instrument further comprises a first handling portion (101) connected to the sleeve, and a second handling portion (102) connected to the holding device. The handling of at least one of the first and second handling portion creates relative displacement of the holding device in relation to the sleeve, which disengages the holding device from the movement restriction device for performing the placement of the movement restriction device.

An obesity treatment apparatus comprises at least one operable stretching device implantable in an obese patient and adapted to stretch a portion of the patient's stomach wall, and an operation device for operating the stretching device when implanted to stretch the stomach wall portion such that satiety is created.

A gastric outflow device is described. The gastric outflow device includes a ring having a ring aperture; and a topper having a topper aperture, the topper attachable to the ring, the topper aperture alignable with the ring aperture to form the gastric outflow device aperture. The gastric outflow device aperture can be adjusted wirelessly, percutaneously, by replacing the topper, and/or by including an expandable compartment surrounding the aperture, the expandable compartment increasing and decreasing the gastric outflow device aperture on being filled with filling material and having the filling material extracted, respectively.

Disclosed are example embodiments of systems and methods for implantation in a pylorus between a stomach and duodenum for promoting weight loss. An example device for implantation in a pylorus between a stomach and duodenum includes a stomach portion configured to anchor the device in the stomach; The example device includes a pyloric portion extending from the stomach portion. The example device includes a duodenal portion extending from the pyloric portion and a channel extending in an axial direction through the stomach portion. The pyloric portion and the duodenal portion, for allowing passage of food material through the device from the stomach to the duodenum. The duodenal portion includes a portion configured to elongate in the axial direction upon compression.

Systems and methods for anchoring and restraining gastrointestinal prostheses are disclosed. In various examples, the systems and methods include securing a gastrointestinal device within a patient's anatomy by extending an anti-migration anchor through a plurality of portions of the gastrointestinal device to couple together the plurality of portions of the gastrointestinal device. In some examples, the anti-migration anchor extends through tissue situated between the plurality of portions of the gastrointestinal device.

An improved gastroesophageal reflux preventer and related methods are provided. The improved gastroesophageal reflux preventer may include an absorbable material able to be placed in contact with a body organ and configured to induce a scarification of the body organ in response to absorption by the body organ of the material. In this manner, a proximate sphincter may be tightened, such as to ameliorate reflux through a gastroesophageal sphincter.

An occlusion device including a first component configured to anchor the occlusion device with respect to a deployment site, and a second component configured to occlude a lumen through the occlusion device. The first component may be in the form of a stent. The second component may be in the form of a stent or in the form of a liner within the first component. The second component includes an occlusion structure configured to extend across (e.g., transverse to the longitudinal axis of) the lumen of the first component. The occlusion structure may be on a retention member of the second component which engages with a retention member of the first component. Additionally or alternatively, the occlusion structure may be a portion of a liner cinched to occlude the lumen through the occlusion device.

Systems and methods are provided for repairing a heart valve, such as a mitral, tricuspid or aortic valve, using an adjustable and removable implant that can be delivered to the heart through the apex in a simplified and non-invasive manner. The implant can include a prosthetic valve portion coupled to a proximal end of a shaft, and an anchor portion coupled to a distal end of the shaft. The prosthetic valve can be suspended within an opening of the heart valve while the anchor portion is affixed to the apex of the heart. When the implant is deployed, a distance between the prosthetic valve portion and the anchor portion can be adjusted, and/or the implant or a portion thereof can be rotated to thereby change the position of the prosthetic valve within the heart valve. This can allow correcting for post-implantation movements of the implant to mitigate potential complications.

A gastrointestinal device for treating obesity includes a three-dimensional porous structure configurable between a compressed pre-deployment configuration to facilitate delivery and an expanded post-deployment configuration. The porous structure includes a first opening at its proximal end and a larger second opening at its distal end. The porous structure also includes a sleeve coupled to its distal end. Optionally, the device further includes a suture at the proximal end of the wire mesh structure to facilitate retrieval and an anti-migration component positioned at the junction of the porous structure with the sleeve. The porous structure is deployed in a patient’s stomach such that the anti-migration component sits proximal to the patient’s pylorus and prevents migration of the entirety of the device into and through the pylorus. The sleeve extends through the pylorus, into the duodenum and ends in the duodenum or jejunum. Food enters the device from the first opening at the proximal end of the porous structure, passes through the porous structure and sleeve, and exits at the distal end of the sleeve. The device treats obesity by providing a relatively immovable volume occupying structure in the stomach and a bypass for food past the pylorus and proximal portion of the small intestine. Optionally, the device further acts to slow the passage of food through the digestive tract. Patients with the device experience satiety more quickly and have a prolonged sensation of satiety.