A device and system are described that are capable of isolating at least one targeted tissue and forming an anastomosis between two internal body structures though a completely endoscopic procedure. Further, the device and system described generally comprise two tubular members that are capable of moving in a telescopic fashion relative to one another. Additionally, a method is described for using the device and/or system to bypass the duodenum from digestion.

A gastroscopic method and instrument for treating obesity of a patient, using a device adapted to stretch a part of the stomach wall of said patient. The method comprises the steps of: inserting the device into the stomach through the esophagus, placing the device in contact with the stomach wall, and fixating the device to the stomach wall such that the device can stretch a part of the stomach wall.

A device for inducing weight loss in a patient includes a tubular prosthesis self-expandable from a collapsed position in which the prosthesis has a first diameter to an expanded position in which the prosthesis has a second, larger, diameter. In a method for inducing weight loss, the prosthesis is placed in the collapsed position and inserted into a stomach of a patient. The prosthesis is allowed to self-expand from the collapsed position to the expanded position and into contact with the walls of the stomach, where it induces feelings of satiety and/or inhibits modulation of satiety-controlling factors such as Ghrelin.

Intestinal devices and methods for facilitating weight loss. In at least one embodiment of a method of patient treatment of the present disclosure, the method comprises the step of positioning a device, that is configured to reduce or limit localized intestinal distension, around a portion of an intestine of a patient.

A gastric calibration tube includes a flexible elongate member, a pushing member, and a balloon member. The flexible elongate member has a proximal end portion, a distal end portion, and an outer surface that extends between the proximal and distal end portions. The outer surface defines a side opening. The flexible elongate member defines a lumen that is in communication with the side opening. The pushing member has a proximal portion and a distal portion. The distal portion is advanceable through the lumen of the flexible elongate member and out of the side opening of the flexible elongate member. The balloon member is secured to one or both of the flexible elongate member and the pushing member. The balloon member is inflatable to fix the gastric calibration tube within a patient's stomach.

A gastrointestinal device and method for retrieving the device are disclosed. The device may include a stent including a plurality of strands forming first and second ends, the strands configured to move between a retrieval configuration, with substantially parallel strands, and a deployed configuration, wherein the strands form proximal and distal portions having first and second diameters larger than the pyloric sphincter. The device may include a connector assembly including proximal, middle, and distal connectors. The middle connector may be coupled to the proximal and distal connectors when the strands are in the deployed configuration. The strands may be attached to the proximal and distal connectors and the first and second ends. The device may include a release mechanism configured to decouple the proximal connector from the middle connector. Decoupling of the proximal and middle connectors may allow the strands to move from the deployed to retrieval configuration.

A liner support frame is configured to be positioned in a gastrointestinal tract of a human and to support a liner which inhibits nutrient absorption and anchor the liner in place in the gastrointestinal tract, the liner support frame includes a plurality of frame members connected to one another so that the liner support frame possesses a plurality of openings. The liner support frame includes a plurality of frame portions arranged axially and possessing different tapers.

An intragastric device including (1) a first wire mesh structure having a pre-deployment shape, a post-deployment shape greater than the pre-deployment state, and one or more openings on an upper portion of the first wire mesh structure that are configured to permit food to enter the device, (2) a second wire mesh structure having a pre-deployment shape a post-deployment shape greater than the pre-deployment state, and one or more openings on a lower portion of the second wire mesh structure that are configured to permit food to exit the device. A sleeve may be coupled to the lower portion of the wire mesh structure. An anti-migration collar may interconnect the wire mesh structure and the sleeve. In use, food enters the upper portion of the first wire mesh structure, passes through both wire mesh structures, and then exits the lower portion of the second wire mesh structure.

An apparatus for treating obesity of a patient having a stomach with a food cavity. The apparatus comprising a volume filling device adapted to be at least substantially invaginated by a stomach wall portion of the patient with the outer surface of the volume filling device resting against the stomach wall, such that the volume of the food cavity is reduced in size by a volume substantially exceeding the volume of the volume filling device. The apparatus further comprises at least one adjustable stretching device adapted to be at least substantially invaginated by a stomach wall portion of the patient with the outer surface of the stretching device resting against the stomach wall and adapted to stretch a portion of stomach wall, and a fluid connection device interconnecting the volume filling device and the stretching device.

A gastrointestinal bypass device for directing food and liquids from an esophagus and/or a proximal portion of a stomach into an intestines is described. The device comprises a receiver, a sleeve, and a device coupling. The receiver may be configured to be positioned in the esophagus and/or the stomach. A proximal portion of the receiver may be configured to open and close to at least partially conform to an inside of the esophagus and/or a proximal portion of the stomach. The receiver may be configured to receive food and liquids from the esophagus and/or a proximal portion of the stomach into a lumen of the receiver. The sleeve may be coupled to a distal portion of the receiver. The sleeve may be configured to be positioned in the stomach and the intestines. The sleeve may have a lumen in communication with the lumen of the receiver. The sleeve may be configured to direct the food and the liquids from the receiver into the intestines. The device coupling may be coupled to the distal portion of the receiver and/or a proximal portion of the sleeve. The device coupling may be configured to be coupled to one or more tissue anchors.