Methods, devices, and systems employ cryolysis of oropharyngeal adipose tissues to selectively remove fat cells from the tissues causing obstructive sleep apnea. In various embodiments, a chilled liquide.g., a liquid or airis applied to the target tissue at a temperature and for a duration sufficient to cause cryolysis.

A method for an eye treatment includes the steps of: providing guide elements made on the specific sites of a subject which comprise (1) a site that intersects a perpendicular line of medial malleolus and an extension line of medial margin on OS metatasale primam 1 and 2, (2) a pupil of a left or right eye, (3) ST 36 point of a left or right leg, and (4) SP point; and controlling a temperature of the guide elements to be a range from 40 to 50?5? C., thereby applying the thermal stimulus to the respective specific sites to increase a blood flow by 60% or more and promote secretion of a growth hormone in the subject.

A thermal wrap having identical side portions, each having a pocket formed therein for receiving thermal material such as gel packs or instant/single use chemically activated thermal packs. The side portions are made of an expandable material and connected at the top by at least two independently attached non-elasticated side straps or loop straps which slide through buckles and attach to two adjacent hook pieces, and at the bottom by a pair of cooperating chin straps made from the same material as the main structure that connects the two pouches which further ensures that the pockets allow for even application as well as increased pressure of thermal energy to the head, neck, or face including the mandibular region of the face according to the users desirable fit and pressure. The pockets are sized to receive standard sized gel packs with dimensions relative to the region of the body being treated.

Methods, devices, and systems employ cryolysis of oropharyngeal adipose tissues to selectively remove fat cells from the tissues causing obstructive sleep apnea. In various embodiments, a chilled liquide.g., a liquid or airis applied to the target tissue at a temperature and for a duration sufficient to cause cryolysis.

Methods, devices, and systems employ cryolysis of oropharyngeal adipose tissues to selectively remove fat cells from the tissues causing obstructive sleep apnea. In various embodiments, a chilled liquide.g., a liquid or airis applied to the target tissue at a temperature and for a duration sufficient to cause cryolysis.

The systems and methods in accordance with the principles of the invention can promote correction of an aesthetic or functional defect in a target tissue. A method can include non-invasively applying a cooling agent to a surface of a target tissue; and cooling one or more tissue layers of said target tissue to a predetermined therapeutic temperature, wherein applying the cooling agent is performed such that cryoablation of said one or more layers of the target tissue does not occur. The system can include: a controller and a probe having a distal end configured for non-invasive contact with a surface of a target tissue to cool the target tissue based on treatment parameters.

A soft thermoformable elastomer with a phase change material exhibiting high latent heat of fusion. The compound provides elasticity, softness, formability, and heat over an extended duration and to facilitate prolonged skin contact at elevated temperatures. Used in combination with active ingredients the increased temperature and formability provides enhanced transdermal delivery through the skin. Thermoplastic elastomers may be manufactured by mixing together plasticizing oil, a triblock copolymer, a paraffinic substance and one or more additives, e.g., an antioxidant, an antimicrobial agent, and/or other additives to form a mixture which melted then cooled into the thermoplastic elastomer. During cooling, the thermoplastic elastomer may be molded or otherwise formed into any number of articles including, but not limited to, prosthetic liners, prosthetic sleeves, external breast prostheses, breast enhancement bladders, masks, wound dressing sheets, wound dressing pads, socks, gloves, malleolus pads, metatarsal pads, shoe insoles, urinary catheters, vascular catheters, and balloons for medical catheters both vascular as well as urinary. Active ingredients are preferably added to the cooling thermoplastic elastomer when the temperature is below 100 F. to prevent heat degradation and/or breakdown of vital proteins.

A nasal cannula system includes a nasal cannula comprising a first elongated prong configured to be inserted into a cavity of a subject, the first elongated prong having a first axial fluid channel, and a first aperture on a side wall of the first elongated prong, the first aperture providing access to the first axial fluid channel. The nasal cannula system can further include a temperature controller configured to regulate a temperature of a fluid prior to the fluid being directed through the first axial fluid channel, and a fluid supply configured to direct the fluid through the first axial fluid channel of the first elongated prong and out of the first aperture to a target area.

A temperature control system includes a nasal cannula. The nasal cannula includes a first elongated prong having a first axial fluid channel and an aperture, providing access to the first axial fluid channel, on a side wall of the first elongated prong. The nasal cannula further includes a second elongated prong having a temperature sensor associated with a distal portion thereof and a fluid supply configured to direct fluid through the first axial fluid channel of the first elongated prong and out of the first aperture to a target area. The nasal cannula further includes control circuitry configured to receive one or more signals from the temperature sensor and modify one or more properties of the fluid in response to the one or more signals from the temperature sensor.

A method for controlling tissue temperature involves providing a nasal cannula including a first elongated prong with an axial fluid channel and a downwardly-curved shape. The nasal cannula further includes a first aperture on a side wall of a distal portion of the first elongated prong. The first aperture provides access to the axial fluid channel. The method includes inserting the first elongated prong into a nasal cavity of a subject to face the first aperture at a pharyngeal wall of the subject and modifying a temperature of the pharyngeal wall by delivering a first fluid portion through the axial fluid channel and out of the first aperture to the pharyngeal wall.