An ophthalmic system may comprise an imaging device having a field of view oriented toward the eye of the patient; a patient interface housing defining a passage therethrough, having a distal end coupled to one or more seals configured to be directly engaged with one or more surfaces of the eye of the patient, and wherein the proximal end is configured to be coupled to the patient workstation such that at least a portion of the field of view of the imaging device passes through the passage; and two or more registration fiducials coupled to the patient interface housing in a predetermined geometric configuration relative to the patient interface housing within the field of view of the imaging device such that they may be imaged by the imaging device in reference to predetermined geometric markers on the eye of the patient which may also be imaged by the imaging device.

Methods and systems for the controlled generation of bubbles in a medium having a liquid phase are generally provided. Laser pulses having a time-dependent pulse parameter controllable over their duration are generated. The medium is irradiated with the laser pulses with a radiant exposure sufficient to initiate microcavitation within the medium during each laser pulse. The time-dependent pulse parameter of each laser pulse is controlled according to a generally positive variation over the pulse duration such that the medium absorbs a greater quantity of energy from the laser pulse at an end of the pulse duration than at a beginning thereof. Such methods and systems may be used for various applications such as biology, medicine or material processing.

Methods and systems wherein laser induced refractive index changes by focused femtosecond laser pulses in optical tissues is performed in combination with corneal lenticular surgery to achieve overall desired vision corrections.

A method for evaluating a laser cut edge of a workpiece includes capturing image data of the laser cut edge and its surroundings, segmenting the image data, and identifying a segment of interest of the image data. The segment of interest comprises image data of the laser cut edge. The method further includes carrying out an image quality detection for the segment of interest and generating, based on the image quality detection, an output for a user.

A full depth ophthalmic surgical system includes a femtosecond laser source and an optical coherence tomographer. The system is capable of performing surgical procedures along the entire length of the eye from the cornea to the retina. The optical system of the ophthalmic surgical system is optimized to focus the laser beam and imaging light in the vitreous humor of the eye. In some embodiments, the system includes a video camera with a tunable lens before it to image the entire length of the eye. For procedures performed posterior to the lens, a method for calibrating the full depth ophthalmic surgical system is also provided. The system can be used to perform treatment in the vitreous humor, including treating floaters and liquification of the vitreous humor.

A system for ophthalmic surgery on an eye includes: a pulsed laser which produces a treatment beam; an OCT imaging assembly capable of creating a continuous depth profile of the eye; an optical scanning system configured to position a focal zone of the treatment beam to a targeted location in three dimensions in one or more floaters in the posterior pole. The system also includes one or more controllers programmed to automatically scan tissues of the patient's eye with the imaging assembly; identify one or more boundaries of the one or more floaters based at least in part on the image data; iii. identify one or more treatment regions based upon the boundaries; and operate the optical scanning system with the pulsed laser to produce a treatment beam directed in a pattern based on the one or more treatment regions.

Rather than rely solely upon pupillary occlusion or tracking of eye movement to protect the fundus from accidental exposure to electromagnetic radiation, the present invention also utilizes an electromagnetic radiation pathway with a profile such that the energy density at the iris is greater than the energy density at the posterior portion of the eye. This disparity in energy density allows for efficacy at the anterior iris treatment site, without injury to the fundus.

A method for providing control data for an ophthalmological laser of a treatment apparatus for treating a cornea, which has been treated with a cross-linking method. The method includes setting conventional laser parameters for removing a predetermined correction volume from the cornea, wherein the laser parameters include at least a laser pulse energy and a number of laser pulses of the laser; providing laser parameters increased in power in areas of the correction volume, in which a cornea changed by the cross-linking method is expected, wherein the laser parameters increased in power have a higher laser pulse energy and/or a higher number of laser pulses compared to the conventional laser parameters; and providing the control data, which includes the laser parameters increased in power in the areas of the correction volume with changed cornea and the conventional laser parameters in the remaining areas of the correction volume.

Systems and methods for removing an epithelial layer disposed over a stromal layer in a cornea irradiate a region of the epithelial layer with a pulsed beam of ablative radiation. The ablative radiation is scanned to vary the location of the beam within the region in accordance with a pulse sequence. The pulse sequence is arranged to enhance optical feedback based on a tissue fluorescence of the epithelial layer. The penetration of the epithelial layer is detected in response to the optical feedback. The use of scanning with the pulse sequence arranged to enhance optical feedback allows large areas of the epithelium to be ablated such penetration of the epithelial layer can be detected.

A method for ophthalmic intervention on an eye of a patient includes: imaging a first and a second registration fiducial in reference to temporary geometric markers on the eye of the patient, the registration fiducials being formed on an inner annulus of a patient interface housing within a field of view of an imaging device; imaging a third registration fiducial formed on the inner annulus of the patient interface housing, the third registration fiducial being angularly spaced from the first and second registration fiducials; and processing image data generated via the image device so as to determine an angular orientation of the eye relative to the patient interface housing and an up or down orientation of the patient interface housing relative to the eye based on the location of the third registration fiducial.