The invention relates to a system for laser photocoagulation of the retina, comprising: a photocoagulation laser (1); an optical path (5) connecting the upstream photocoagulation laser (1) to a downstream laser outlet opening (6) intended to be positioned in front of the retina; an adaptive optical element (9) positioned in the optical path and configured to modify the wavefront of the laser beam being propagated in the optical path, in order to compensate for aberrations of the eye that occur as far as the retina; a position control loop (10) controlling a first actuator (14) positioned in the optical path downstream of the adaptive optical element in order to control the position of the laser outlet opening relative to the retina to be treated; and at least one imaging device (8) configured to obtain an image of the retina diverted from the optical path.

Systems and methods for creating multi-spot laser light beams, multiplexing an illumination light and the multi-spot laser light beams, and delivering the multiplexed light to a surgical handpiece via a multi-core optical fiber cable.

Certain embodiments of the present disclosure provide a thermally robust laser probe assembly. The probe assembly comprises a cannula through which one or more optical fibers extend at least partially for transmitting laser light from a laser source to a target location. The probe assembly also comprises a lens housed in the cannula and a protective component at a distal end of the cannula, wherein the lens is positioned between the one or more optical fibers and the protective component, and wherein the distal end of the cannula is sealed at a sealing location of the probe assembly.

A system (20) includes a radiation source (48) and a controller (44), configured to display a live sequence of images of an eye (25) of a patient (22), while displaying the sequence of images, cause the radiation source to irradiate the eye with one or more aiming beams (84), which are visible in the images, subsequently to causing the radiation source to irradiate the eye with the aiming beams, receive a confirmation input from a user, and in response to receiving the confirmation input, treat the eye by causing the radiation source to irradiate respective target regions of the eye with a plurality of treatment beams. Other embodiments are also described.

A photocoagulation apparatus of some embodiment examples is configured to apply both treatment light for subthreshold coagulation and an OCT scan to a retina via a probe inserted in an eye. Upon receiving a user's instruction, the apparatus applies the treatment light to the retina, and applies an OCT scan to the retina at least after the treatment light application. The apparatus compares the first OCT image constructed from OCT data of the retina acquired prior to the treatment light application and the second OCT image constructed from OCT data of the retina acquired after the treatment light application, thereby acquiring change information that represents a tissue change in the retina caused by the treatment light. The apparatus displays a change image based on the change information together with a retinal image.

An ophthalmic treatment system and method for performing therapy on target tissue in a patient's eye. A delivery system delivers treatment light to the patient's eye and a camera captures a live image of the patient's eye. Control electronics control the delivery system, register a pre-treatment image of the patient's eye to the camera's live image (where the pre-treatment image includes a treatment template that identifies target tissue within the patient's eye), and verify whether or not the delivery system is aligned to the target tissue defined by the treatment template. The control electronics control the delivery system to project the treatment light onto the patient's eye in response to both an activation of a trigger device and the verification that the delivery system is aligned to the target tissue, as well as adjust delivery system alignment to track eye movement.

A laser system calibration method and system are provided. In some methods, a calibration plate may be used to calibrate a video camera of the laser system. The video camera pixel locations may be mapped to the physical space. A xy-scan device of the laser system may be calibrated by defining control parameters for actuating components of the xy-scan device to scan a beam to a series of locations. Optionally, the beam may be scanned to a series of locations on a fluorescent plate. The video camera may be used to capture reflected light from the fluorescent plate. The xy-scan device may then be calibrated by mapping the xy-scan device control parameters to physical locations. A desired z-depth focus may be determined by defining control parameters for focusing a beam to different depths. The video camera or a confocal detector may be used to detect the scanned depths.

Certain aspects of the present disclosure provide a thermally robust laser probe assembly comprising a cannula, wherein one or more optical fibers extend at least partially through the cannula for transmitting laser light from a laser source to a target location. The probe assembly further comprises a lens housed in the cannula and a protective component press-fitted to the distal end of the cannula, wherein the lens is positioned between the one or more optical fibers and the protective component.

A multi-spot ophthalmic laser device that produces spatially distributed laser spots with the spatial distribution of the laser spots defined by a spot diameter to space ratio in the range 1:2 to 1:20. The multi-spot ophthalmic laser device comprises: a laser module producing a laser pulse or sequence of laser pulses each having: a pulse duration in the range of 10 ps to 20 μs; a wavelength in the range 500 nm to 900 nm; and a pulse energy in the range 10 μJ to 10 mJ per pulse; and an optical beam profiling module that modifies an output beam profile of each pulse of the laser module to deliver multiple spatially distributed laser spots of defined size and energy. The multi-spot ophthalmic laser device is used in a method of improving the function of the retina of a human eye by irradiation through the cornea of the eye to the retinal pigmented epithelium by a treatment laser having a beam profile with spatially distributed energy peaks.

An ophthalmic laser treatment delivers patterned laser energy to an eye of a patient. A pattern-scanning laser device of the laser treatment system includes a laser module, a scanning module and delivery optics. The laser module generates laser energy (e.g. via a green laser diode), which is directed to the scanning module via a fiber optic cable. The scanning module produces the patterned laser energy by reflecting the laser energy into the delivery optics at different angles via a dielectric MEMS scanning mirror. The delivery optics includes an F-theta lens, a motorized and wirelessly-controlled spot-size selector module, and a focusing lens. A mobile computing device receives parameter information via a graphical user interface or voice control and sends the parameter information to the pattern-scanning laser device. In response to receiving activation signals from an activation unit, the pattern-scanning laser device emits the patterned laser energy based on the parameter information.