An imaging system for an ophthalmic laser system includes a prism cone made of a transparent optical material and disposed downstream of the focusing objective lens of the ophthalmic laser system, the prism cone having an upper surface, a lower surface parallel to the upper surface, a tapered side surface between the upper and lower surfaces, and a beveled surface formed at an upper edge of the prism cone and intersecting the upper surface and the side surface, and a camera disposed adjacent to the prism cone and facing the beveled surface. The camera is disposed to directly receive light that enters the lower surface of the prism cone and exits the beveled surface without having been reflected by any surface.

Methods for treatment of dry eye and other acute or chronic inflammatory processes are disclosed herein. One method includes administering a drug delivery implant to a patient in need thereof, the drug delivery implant comprising one or more Rock inhibitors and/or one or more Wnt inhibitors, the patient having a medical condition selected from the group consisting of dry eye, lichen planus, arthritis, psoriasis, plantar fasciitis, pars planitis, scleritis, keratitis, chronic meibomian gland inflammation, optic nerve neuritis, uveitis, papillitis, diabetic neural pain, diabetic retinopathy, a cataract, a side effect occurring after refractive surgery, a side effect occurring after corneal transplant, a side effect occurring after retinal detachment surgery, and combinations thereof. The administration of the drug delivery implant to the patient treats the medical condition, reduces the symptoms associated with the medical condition, enhances nerve regeneration, and/or alleviates the medical condition.

A motor position compensation method for an ophthalmic surgical laser system employs a deep artificial neural network to characterize motor following errors of the motors of the system. The artificial neural network is trained using a large number of commanded motor positions and corresponding measured actual motor positions (measured by encoders associated with the motors) as training data, to obtain a trained artificial neural network that can predict the actual motor position for any commanded motor position. Before executing a treatment scan, the original commanded motor positions calculated from the intended scan pattern are inputted to the trained artificial neural network to predict the actual motor positions, and the predicted actual motor positions are used to adjust the original commanded motor positions. The adjusted commanded motor positions are then used to perform the treatment scan, which produces an actual scan pattern that more closely match the intended scan pattern.

The disclosure provides a system that may: receive data associated with multiple locations associated with a cornea of an eye; adjust at least one lens, based at least on diameter information of the data associated with at least one of the multiple locations, to set a diameter of a laser beam; and for each location of the multiple locations: determine if the eye has changed from a first position to a second position; if the eye has not changed from the first position to the second position, adjust, based at least on the location, at least one mirror; if the eye has changed from the first position to the second position, adjust, based at least on the location and based at least on the second position, the at least one mirror; produce the laser beam; and direct the laser beam to the location for a period of time.

The invention provides an excimer laser system including a means for calibrating laser output to compensate for increased variation in laser optical fibers.

A device for producing control data for a laser device for the surgical correction of defective vision. The device produces the control data such that the laser emits the laser radiation such that a volume in the cornea is isolated. The device calculates a radius of curvature R.sub.CV* to determine the control data, the cornea reduced by the volume having the radius of curvature R.sub.CV* and the radius of curvature being site-specific and satisfying the following equation: R.sub.CV*(r,φ)=1/((1/R.sub.CV(r,φ))+B.sub.COR(r,φ)/(n.sub.c-1))+F, wherein R.sub.CV(r,φ) is the local radius of curvature of the cornea before the volume is removed, n.sub.c is the refractive index of the material of the cornea, F is a coefficient, and B.sub.COR(r,φ) is the local change in refractive force required for the desired correction of defective vision in a plane lying in the vertex of the cornea, and at least two radii r1 and r2 satisfy the equation B.sub.COR(r=r1,φ)≠B.sub.COR(r=r2,φ).

A planning device for generating control data for a treatment apparatus which by means of a laser device produces at least one incision surface in the cornea, and to a treatment apparatus having such a planning device. The invention further relates to a method for generating control data for a treatment apparatus which by using a laser device produces at least one incision surface in the cornea, and to a corresponding ophthalmic surgery method. The planning device is thereby provided with calculation means for defining the corneal incision surfaces, wherein the calculation means determine the corneal incision surfaces on the basis of data of a LIRIC structure and/or a refractive correction, and generate for the corneal incision surfaces a control data set for controlling the laser device, wherein the calculation means determine the corneal incision surfaces in such a manner that the LIRIC structure is enclosed by the incision surfaces.

For the purposes of working on eye tissue, an ophthalmological apparatus comprises a laser source that is configured to produce a pulsed laser beam, a focusing optical unit that is configured to focus the pulsed laser beam into the eye tissue, and a scanner system for deflecting the pulsed laser beam onto work target points in the eye tissue. The scanner system is configured to guide the pulsed laser beam onto work target points along a scan line that extends across a work line at an alignment angle and to tilt the scan line depending on the work target point on the work line in such a way that the scan line extends substantially along an outer face of a lenticule to be cut in the eye tissue.

The present disclosure provides a system and method for cutting a flap in laser ophthalmic surgery using polarization sensitive optical coherence tomography (PS-OCT). The system includes a PS-OCT system, a femtosecond laser, control device, and processor. The PS-OCT system includes a PS-OCT source, a polarization component, a reference reflector, a beam splitter, a wave plate, and a detector. The processor receives data relating to an interference pattern of a reflected PS-OCT beam, received at the detector, determines a relative fiber orientation of the sample, determines whether a photodisruption pattern generated by the femtosecond laser to cut the flap should be adjusted horizontally or vertically, based on the relative fiber orientation, and may generate a control signal to adjust the photodisruption pattern generated by the femtosecond laser. The disclosure further provides a method for cutting a flap on an eye using PS-OCT.

The present disclosure provides a femtosecond laser docking apparatus that includes a suction cone, with an upper frusto-conical portion and lower spherical portion, and a suction ring, with a mechanical stop and at least one contact and sealing surface. The mechanical stop engages the spherical portion of the suction cone to prevent it from being lowered further toward an eye, in a z-direction, beyond the mechanical stop. This disclosure provides a system for femtosecond laser ophthalmic surgery that includes a suction cone, with an upper frusto-conical portion and lower spherical portion, and a suction ring. This disclosure further provides a method for docking a femtosecond laser that includes positioning a suction ring on an eye, lowering a suction cone toward the eye until it engages the mechanical stop of the suction ring, and applying suction to seal the suction cone to the suction ring by a contact and sealing surface.