A method of corneal implantation with cross-linking is disclosed herein. In one or more embodiments, the method includes the steps of: (i) prior to implantation, treating an implant formed from donor corneal tissue or a tissue culture grown corneal stroma with a solution of sodium dodecyl sulfate (SDS), Triton X-100, benzalkonium chloride (BAK), Igepal, genipin, 100% glycerol, or alcohol for making the implant acellular, and for killing any bacteria, viruses, or parasites prior to implantation; (ii) implanting the implant into a recipient cornea; (iii) applying laser energy to the implant so as to modify the refractive power of the implant while being monitored using a Shack-Hartmann wavefront system so as to achieve a desired refractive power for the implant; and (iv) applying a cross-linking solution and irradiating the implant to cross-link the implant to prevent an immune response to the implant and/or rejection of the implant by a patient.

A method of forming and implanting a synthetic corneal lenslet in an eye of a patient includes the steps of: forming a synthetic lenslet from a collagen solution using a mold or a 3-D printer that are configured to form the synthetic lenslet into a predetermined shape for correcting a particular refractive error of the patient; forming a cavity for receiving the synthetic lenslet in the cornea of the eye of the patient; inserting the synthetic lenslet into the cavity of the eye; applying a photosensitizer into the cavity of the eye so that the photosensitizer permeates at least a portion of the tissue surrounding the cavity and at least a portion of the synthetic lenslet; and irradiating the cornea so as to activate cross-linkers in the synthetic lenslet and cross-linkers in the portion of the tissue surrounding the cavity, and thereby prevent an immune response.

The invention provides a laser system for performing an intraocular procedure. The laser system includes a single use, disposable laser probe configured to be coupled to a laser source and transmit laser energy from the laser source to a target tissue for treatment thereof. The laser probe comprises a laser transmitting member including a fiber optic core comprising a delivery tip for transmitting laser energy from the laser source to the target tissue during a procedure. The laser probe further includes a light emitting member providing illumination in a field of view proximate to the delivery tip of the fiber core, thereby providing a clear field of view for a surgeon during laser treatment of the target tissue.

The invention provides personalized laser probes for use in laser systems, wherein each laser probe includes one or more characteristics tailored to a given user to thereby improve performance of and outcome of a laser treatment procedure.

The invention provides an excimer laser system including a means for calibrating laser output to compensate for increased variation in laser optical fibers.

The present invention relates to a laser surgery apparatus for contact laser surgery and to a method of using the laser surgery apparatus. The laser surgery apparatus (1) comprises a contact laser scalpel (3) for contact laser surgery, the contact laser scalpel (4) comprising an optical fiber (4) of IR laser radiation transmissive material and terminating at an optical fiber tip (5) having an exposed core region, and support means for holding said fiber and for positioning said scalpel (3). Said fiber tip (5) is tapered and disposed at a distal end of the scalpel (3) for contacting a tissue to be cut and comprises an uncoated contact surface (6) for transmit ting laser radiation and a guiding surface that is at least partially reflective to laser radiation and provided such that laser radiation guided by said optical fiber (4) to said fiber tip (5) will be at least partially reflected by said guiding surface and emitted through said uncoated contact surface. The contact laser surgery apparatus further comprises a pulsed laser source (2) adapted to provide pulse durations in the femtosecond, picosecond and/or nanosecond range, and light transmitting means (9) connecting said laser source (2) to said optical fiber (4) of said scalpel (3) for conveying laser radiation from said laser source (2) to said optical fiber (4) such that the conveyed laser light is emitted at said uncoated contact surface of the fiber tip.

An ophthalmic surgical laser system includes: a laser that produces a pulsed laser beam having a pulse energy and pulse repetition rate; a high frequency fast scanner; an XY-scan device; a Z-scan device; and a controller. The controller controls the high frequency scanner to produce a scan line having a scan width; controls the XY-scan device and the Z-scan device to carry out of first sweep of the scan line in a first sweep direction and to carry out a second sweep of the scan line in a second sweep direction that is not parallel to the first sweep direction thereby defining an overlap region. At least one of the pulse energy, repetition rate, XY-scan speed, and the scan width is varied so as to accelerate the cutting speed and reduce the exposure of ophthalmic tissue in the overlap region to multiple exposures of laser pulses configured to modify ophthalmic tissue.

The disclosure provides a system that may acquire, via an image sensor, an image of an eye of a person; may determine a location of an iris of the eye from the image; may determine a position of a suction ring from the image; may display, via a display, the image; may display, via the display, a first graphic overlay on the image that indicates the location of the iris of the eye; may display, via the display, a second graphic overlay on the image that indicates the position of the suction ring; may determine multiple iris structures from the image; may determine an orientation of the eye based at least on the multiple iris structures from the image; and may display, via the display, information that indicates the orientation of the eye.

For the purposes of working on eye tissue, an ophthalmological apparatus comprises a laser source that is configured to produce a pulsed laser beam, a focusing optical unit that is configured to focus the pulsed laser beam into the eye tissue, and a scanner system for deflecting the pulsed laser beam onto work target points in the eye tissue. A circuit controls the scanner system in such a way that the scanner system guides the pulsed laser beam into work trajectories that extend next to one another, in order, initially, to produce cut trajectories, separated by remaining tissue bridges, of a tissue cut to be undertaken in an area and in order, thereafter, to guide the pulsed laser beam in the remaining tissue bridges between the cut trajectories in order to complete the tissue cut.

A method for controlling an eye surgical laser for the separation of a volume body with predefined posterior and anterior interfaces from a human/animal cornea is disclosed. The method including controlling the laser by means of a control device wherein the laser emits pulsed laser pulses in a predefined pattern into the cornea. The interfaces of the volume body are defined by the predefined pattern and are generated by means of an interaction of the individual laser pulses with the cornea by means of photodisruption. The control device controls the laser beam such that both interfaces are generated by means of a continuous, uninterrupted sequence of laser pulses. A treatment device is disclosed with at least one eye surgical laser for the separation of a predefined corneal volume with predefined interfaces of a human/animal eye by means of photodisruption and with at least one control device for the laser(s).