An ophthalmic laser treatment device includes an irradiation unit that irradiates a patient's eye with laser treatment light and a control unit that controls the irradiation unit. The control unit acquires a motion contrast acquired by an OCT unit that detects an OCT signal of measurement light reflected from the patients eye and reference light corresponding to the measurement light, acquires irradiation target information based on the motion contrast, and controls the irradiation unit so as to irradiate the patient's eye with the laser light, based on the irradiation target information.

A method for increasing the blood flow and metabolic rate of the eye fundus by (1) irradiating the eye fundus through the pupil by using red light or near-infrared light in a certain wavelength range, a certain energy density range and a certain irradiation time range; (2) once irradiation is complete, repeating the irradiating at intervals of a certain time range, using red light or near-infrared light in the same wavelength range and the same energy density range to irradiate the eye fundus through the pupil.

The present disclosure relates to a multi-core optical fiber cable (MCF). In some embodiments, an MCF comprises a plurality of cores surrounded by a cladding and a coating surrounding the cladding, wherein a refractive index of one or more of the plurality of cores is greater than a refractive index of the cladding. The MCF further comprises a probe comprising a probe tip coupled with a distal end of the MCF and a lens located at a distal end of the probe tip. In some embodiments, the lens is configured to translate laser light from the distal end of the MCF to create a multi-spot pattern of laser beams on a target surface and a distal end of the MCF terminates at an interface with the lens.

An apparatus to treat refractive error of the eye comprises one or more optics configured to project stimuli comprising out of focus images onto the peripheral retina outside the macula. While the stimuli can be configured in many ways, in some embodiments the stimuli are arranged to decrease interference with central vison such as macular vision. The stimuli can be out of focus images may comprise an amount of defocus within a range from about 3 Diopters (“D”) to about 6 D. In some embodiments, the brightness of the stimuli is greater than a brightness of background illumination by an appropriate amount such as at least 3 times the background brightness. In some embodiments, each of a plurality of stimuli comprises a spatial frequency distribution with an amplitude profile having spatial frequencies within a range from about range of 1×10.sup.−1 to 2.5×10.sup.1 cycles per degree.

Rather than rely solely upon pupillary occlusion or tracking of eye movement to protect the fundus from accidental exposure to electromagnetic radiation, the present invention also utilizes an electromagnetic radiation pathway with a profile such that the energy density at the iris is greater than the energy density at the posterior portion of the eye. This disparity in energy density allows for efficacy at the anterior iris treatment site, without injury to the fundus.

In the solution of the invention at least one an electrical response signal from a retina is acquired in a first temperature, at least one electrical response signal from the retina is acquired in at least a second temperature, the second temperature being different than the first temperature. At least the electrical response signal acquired in the second temperature is transformed with a plurality of different transformation parameter values resulting a plurality of different transformed signals. The different transformed signals of the electrical response signal in the second temperature are compared to the electrical response signal and/or the transformed signals acquired from the retina in the first temperature. The transformed electrical response signal which produces the highest similarity measure with the electrical response signal and/or transformed signal acquired from the retina in the first temperature is selected. The transformation parameter value or parameter values of the selected transformed signal is converted to a temperature, temperature difference estimate and/or temperature dependent indicator between the first temperature and the second temperature.

Certain aspects of the present disclosure provide a probe comprising a tube, wherein one or more optical fibers extend at least partially through the tube for transmitting at least one of a laser light and an illumination light from a light source to a target location. A distal end of the tube comprises a flat-walled morphology, and a protective window with a round edge is press-fit to the distal end. The flat-walled morphology of the distal end of the tube has a reduced diametric interference sensitivity, thus allowing a wider range of tolerances between the window and the tube walls for effective press-fitting.

Photobiomedulation therapy (PBMT) can be applied to the eye to treat optical neuritis, a sign of multiple sclerosis (MS). The light of PBMT can be directed into the eye, regardless of the position of the eye, by a device that includes an array of light delivery devices and a heat sink lens. The device can be placed proximal to the eye to direct the light into the eye. The light can have one or more wavelengths from 400-1100 nm and can be applied in at least one of a pulsed operating mode, a continuous operating mode, and a super-pulsed operating mode through the light source device to the skeletal muscle. The light signal is applied for a time sufficient to stimulate a phototherapeutic response in the retina and/or the optic nerve. PBMT applied in this manner provides a noninvasive, safe and effective treatment for optic neuritis.

Certain aspects of the present disclosure provide a thermally robust laser probe assembly comprising a cannula, wherein one or more optical fibers extend at least partially through the cannula for transmitting laser light from a laser source to a target location. The probe assembly further comprises a lens housed in the cannula and a protective component press-fitted to the distal end of the cannula, wherein the lens is positioned between the one or more optical fibers and the protective component.

Some embodiments disclosed here provide for a method fragmenting a cataractous lens of a patient's eye using an ultra-short pulsed laser. The method can include determining, within a lens of a patient's eye, a high NA zone where a cone angle of a laser beam with a high numerical aperture is not shadowed by the iris, and a low NA zone radially closer to the iris where the cone angle of the laser beam with a low numerical aperture is not shadowed by the iris. Laser lens fragmentation is accomplished by delivering the laser beam with the high numerical aperture to the high NA zone, and the laser beam with the low numerical aperture to the low NA zone. This can result in a more effective fragmentation of a nucleus of the lens without exposing the retina to radiation above safety standards.