An apparatus to treat refractive error of the eye comprises one or more optics configured to project stimuli comprising out of focus images onto the peripheral retina outside the macula. While the stimuli can be configured in many ways, in some embodiments the stimuli are arranged to decrease interference with central vison such as macular vision. The stimuli can be out of focus images may comprise an amount of defocus within a range from about 3 Diopters (“D”) to about 6 D. In some embodiments, the brightness of the stimuli is greater than a brightness of background illumination by an appropriate amount such as at least 3 times the background brightness. In some embodiments, each of a plurality of stimuli comprises a spatial frequency distribution with an amplitude profile having spatial frequencies within a range from about range of 1×10.sup.−1 to 2.5×10.sup.1 cycles per degree.

A method of integrating or fusing at least a part of a retina and at least one of a retinal pigmented epithelium (RPE) and choroid underlying the retina and the RPE is disclosed. The method comprises photodehydrating at least some proximal fluid separating one or more of the retina, the RPE and the underlying choroid, with photodehydrating laser light to thereby allow direct contact between the retina and at least one or more of the RPE and choroid. The method further comprises drying at least some of the proximal fluid with a gas flowing at a rate of up to 200 ml/min and photocoagulating with photocoagulating laser light to thereby integrate or fuse at least part of the retina with one or both of the RPE and choroid. Also provided are a device and a system for integrating or fusing these tissues.

Provided herein is a probe for treating an eye of a patient. In one or more embodiments, the probe includes a body, and a tubular element having a main lumen extending from the body, the tubular element comprising a distal end. The probe further includes a visualization optical fiber within the main lumen, the visualization optical fiber adapted to emit an illumination provided by at least one of a plurality of light sources connected to the visualization optical fiber. In some embodiments, the probe further includes an optical switching system (e.g., a time-division multiplexor) operable with the plurality of light sources, wherein the optical switching system is adapted to independently control each of the plurality of light sources. By providing time-division multiplexing between different surgical light sources, quasi-simultaneous illumination delivery through the same optical path may be achieved.

Disorders of the eye can be treated by photobiomodulation therapy according to a device designed to direct light into a patient's eye, no matter the configuration of the eye. The device, including a printed circuit board that includes an array of light delivery devices and a heat sink lens, can be placed proximal to the patient's eye. The light delivery devices can be powered to generate light. The light can be directed into the patient's eye regardless of a position of the patient's eye.

Photobiomedulation therapy (PBMT) can be applied to the eye to treat optical neuritis, a sign of multiple sclerosis (MS). The light of PBMT can be directed into the eye, regardless of the position of the eye, by a device that includes an array of light delivery devices and a heat sink lens. The device can be placed proximal to the eye to direct the light into the eye. The light can have one or more wavelengths from 400-1100 nm and can be applied in at least one of a pulsed operating mode, a continuous operating mode, and a super-pulsed operating mode through the light source device to the skeletal muscle. The light signal is applied for a time sufficient to stimulate a phototherapeutic response in the retina and/or the optic nerve. PBMT applied in this manner provides a noninvasive, safe and effective treatment for optic neuritis.

In some embodiments, a system for providing a therapeutic treatment to a patient's eye includes a treatment beam source configured to transmit a treatment beam along a treatment beam path. The system further includes a processor coupled to the treatment beam source, the processor being configured to direct the treatment beam onto retinal tissue of the patient's eye and deliver a series of short duration pulses from the treatment beam onto the retinal tissue at a first treatment spot to treat the retinal tissue. In some embodiments, a pre-treatment evaluation method using electroretinography (ERG) data may be used to predict effects of treatment beams at different power values and to determine optimal power values.

A device for obtaining retinal ERG signals from a target area of the retina, the device comprising means for obtaining an electrical response signal from the target area and at least one light source configured to provide at least a stimulus beam configured to illuminate the target area for inducing an ERG signal and a light adapting background beam configured to illuminate the retina at least in an area outside of the target area, for light adapting the area outside of the target area and suppressing ERG signaling therefrom.

In certain embodiments, a system for sensing occlusions in an optical system includes a first laser source configured to generate optical signals and a set of optical elements arranged to receive the optical signals from the first laser source and to direct the optical signals along a beam path. The system also includes a detector arranged to receive reflections of the optical signals traveling along at least a portion of the beam path and a control system communicably coupled to the detector. The control system is configured to detect, based on signals generated by the detector, reflection signals associated with the reflections of the optical signals, and disable a second laser source based on detection of the reflection signals.

Proposed are a laser feedback device for irradiation to an eyeball and a laser feedback method using the same, the laser feedback device comprising: a guide beam irradiation unit for irradiating a guide beam to an eyeball of a patient; a reflection unit positioned adjacent to the guide beam irradiation unit; a laser irradiation unit for irradiating a laser into the eyeball; an image acquisition unit that receives a reflection beam reflected from the eyeball and refracted through the reflection unit and acquires at least one retinal image of the retina of the eyeball; and an image mapping unit that maps at least one retinal image to construct a macular image which is a full image of the macula of the eyeball.

Disclosed are a smart auxiliary diagnosis system and method for fundus oculi laser surgery, comprising a imaging stabilization and laser treatment device (1), a data control device (2), an image display device (3), and a data processing device (4); a first database (41) thereof stores fundus oculi image data; disease feature data in a fundus oculi image is extracted by means of a feature extraction module (42); a data analysis matching module (45) is used to perform a comparison operation, perform matching with disease feature data stored in a known-case feature template library (44), and store the result of the matching operation in a second database (43); if the degree of matching exceeds a set threshold, then a corresponding auxiliary diagnosis conclusion is provided, and an auxiliary diagnosis report is generated by means of a diagnosis report generation module (46).