In certain embodiments, an ophthalmic laser surgical system for imaging and treating a target in an eye includes an imaging system with an optical coherence tomography (OCT) device that directs an OCT imaging beam along an imaging beam path towards the target in the eye, and generates OCT images from the OCT imaging beam reflected from the eye. The beam combining and alignment device aligns the OCT imaging beam and the laser beam. The laser-OCT xy-scanner: receives the OCT imaging beam from the imaging system, directs the OCT imaging beam along the imaging beam path towards the eye, and scans the OCT imaging beam in an xy-plane in the eye; and receives the laser beam from the laser device, directs the laser beam along the laser beam path aligned with the imaging beam path towards the eye, and scans the laser beam in the xy-plane in the eye.

In certain embodiments, an ophthalmic laser surgical system for imaging and treating a target in an eye includes an optical coherence tomography (OCT) device that: directs an imaging beam towards the eye; generates three-dimensional (3D) image data from the imaging beam reflected from the eye; and generates two-dimensional (2D) enface images from the 3D image data. The 2D enface images include a target enface image imaging the target in the eye and a retinal enface image imaging a shadow cast by the target onto the retina. An xy-scanner directs the imaging beam along an imaging beam path towards the eye, and directs a laser beam from the laser device along a laser beam path aligned with the imaging beam path towards the eye. A computer compares the target of the target enface image and the shadow of the retinal enface image to confirm the presence of the target.

Certain embodiments provide an apparatus comprising a hand-piece, an outer tube coupled to the hand-piece, an inner tube housed within the outer tube and having a distal end coupled to a soft tip and a proximal end coupled to an adapter, a proximal end of the adapter coupled to a distal end of a valve, the valve slidably coupled to the hand-piece, and a core slidably coupled to the hand-piece and having a distal end coupled to a proximal end of the valve. To retract the soft tip, the valve is retracted, causing the adapter, the valve, and the core to slidably retract in a proximal direction in relation to the hand-piece, and to extend the soft tip, the valve is protracted, causing the adapter, the valve, and the core to slidably protract in a distal direction in relation to the hand-piece.

In certain embodiments, an ophthalmic system includes an anamorphic depth gauge (ADG) device and a computer. The ADG device measures the z-location in the interior of an eye and includes a detector array arranged at an oblique angle with respect to the z-axis. The array generates a detector signal in response to detecting a light beam, which has a z-focus in the interior of the eye. A set of line focus optical elements focuses the light beam to form a line focus on the detector array, and a set of nominal focus optical elements focuses the light beam to form a nominal focus on the detector array. The computer: generates an image using the detector signal; determines the position of the nominal focus on the line focus according to the image; and determines the z-location of the z-focus from the position of the nominal focus on the line focus.

The present disclosure generally relates to microsurgical instruments for ophthalmic surgical procedures, and more particularly, methods and microsurgical instruments for vitreoretinal procedures. In certain embodiments described herein, a vitreoretinal procedure is performed utilizing two surgical instruments: 1) a treatment instrument configured to a) treat a target ophthalmic tissue (e.g., sever and remove the vitreous body), and b) infuse fluid into the intraocular space to maintain intraocular pressure (IOP); and 2) an illumination probe for providing illumination within the intraocular space. The combined treatment and infusion functionalities of the treatment instrument eliminate the need for a separate infusion cannula, thus enabling the vitreoretinal procedure to be performed with only two instruments and reducing the number of incisions made in the eye. Additionally, utilization of two instruments facilitates easier manipulation of the eye by a surgeon, as one of the two instruments can be used to steer the eye during the procedure.

In certain embodiments, an ophthalmic laser system for treating a floater in a vitreous of an eye includes a laser device that directs laser pulses towards the floater to yield cavitation bubbles that create a bubble jet to treat the floater. In some examples, the laser device includes a beam multiplexer that splits a laser beam into multiple beams that form the cavitation bubbles that create the bubble jet. In some examples, the laser device directs laser pulses towards the floater according to a pulse pattern that forms the cavitation bubbles that create the bubble jet.

A composition includes particles for use in a method for the treatment of a vitreous disease or a vitreous disorder as a light sensitizing agent. Each particle has a surface selected for or adapted for providing mobility of the particle in the vitreous and for binding to collagen aggregates, such as floaters.

In certain embodiments, an ophthalmic system is provided. The ophthalmic system includes a low power laser source configured to generate a low power laser beam, wherein the low power laser source has a power of between 5 milliwatts (mW) and 20 mW, and a first illumination device configured to transmit the low power laser beam into a vitreous cavity of an eye. The ophthalmic system further includes a red-green-blue (RGB) light-emitting diode (LED) light source configured to generate a RGB light, and a second illumination device configured to transmit the RGB light into the vitreous cavity of the eye.

In certain embodiments, an ophthalmic surgical system for viewing an eye includes an ophthalmic microscope and a laser device. The ophthalmic microscope receives light reflected or scattered backwards from within the vitreous of the eye in order to provide an image of an object within the vitreous. The ophthalmic microscope includes a slit illumination source (which includes a light source and an optical element), a spectral filter, and oculars. The slit illumination source illuminates the eye with light, where the light source provides the light, and the optical element directs the light into the eye. The spectral filter filters out red spectral components of the light. The oculars receive the light from the eye in order to provide the image of the object. The laser device generates a laser beam to direct towards the object within the eye.

System and method for using in treatment of an opacity within an eye are presented, the system comprising an input utility configured to receive input data comprising image data of the eye being indicative of a convergence spot of first and second aiming beams entering the eye and converging at location of an opacity within the eye, and of first and second spots formed on the retina by respectively the first and second aiming beams; a processing utility configured to process the input data, the processing comprises processing the image data and determining an inter-spot distance between the first and second spots formed on the retina, and utilizing the inter-spot distance and a model of the eye and determining a first distance between the opacity and the retina and a second distance between the opacity and the crystalline lens of the eye; and an output utility configured and operable to generate output data indicative of opacity treatment recommendation based on the first and second distances.