The presently disclosed subject matter provides techniques for inducing collagen cross-linking in human tissue, such as cartilage, by inducing ionization of the water contained in the tissue to produce free radicals that induce chemical cross-linking in the human tissue. In an embodiment, a femtosecond laser operates at sufficiently low laser pulse energy to avoid optical breakdown of the tissue being treated. In an embodiment, the femtosecond laser operates in the infrared frequency range.

Disclosed are systems, devices and methods for laser microporation for rejuvenation of tissue of the eye, for example, regarding aging of connective tissue and rejuvenation of connective tissue by scleral rejuvenation. The systems, devices and methods disclosed herein restore physiological functions of the eye including restoring physiological accommodation or physiological pseudo-accommodation through natural physiological and biomechanical phenomena associated with natural accommodation of the eye. In some embodiments, the laser system may be configured to treat ocular tissue off axis or in a region of the eye which is distinct from the visual axis or directed away from the pupil of the eye where the gaze of the eye is.

A device for defining a flap geometry of a flap for laser treatment of a human eye comprises a control unit programmed to evaluate ablation profile data of an ablation profile for a laser ablation treatment of a human cornea and to define the flap geometry based on this evaluation.

An initial treatment pattern defining an initial volume of ocular tissue to be modified for treating glaucoma is designed. An initial laser treatment is delivered by scanning a laser beam across ocular tissue at an initial placement in the eye in accordance with the initial treatment pattern to thereby photo disrupt the initial volume of ocular tissue. A postoperative measure of intraocular pressure (IOP) is evaluated relative to an IOP criterion to determine if the treatment was successful. If the treatment was not successful, meaning the IOP criterion was not satisfied, then a subsequent treatment pattern that defines a subsequent volume of ocular tissue to be modified, and/or a subsequent placement in the eye is determined. A subsequent laser treatment is delivered by scanning a laser beam across ocular tissue at the subsequent placement within the eye in accordance with the subsequent treatment pattern to thereby photo disrupt the subsequent volume of ocular tissue.

Method for controlling an eye surgical laser (18) of a treatment device (10) for the separation of a volume body (12) with a predefined posterior interface (14) and a predefined anterior interface (16) from a human or animal cornea, comprising controlling the laser (18) by means of a control device (20) of the treatment device (10) such that it emits pulsed laser pulses in a shot sequence in a predefined pattern into the cornea, wherein the interfaces (14, 16) of the volume body (12) to be separated are defined by the predefined pattern and the interfaces (14, 16) are generated by means of an interaction of the individual laser pulses with the cornea by the generation of a plurality of cavitation bubbles generated by photodisruption, wherein the plurality of cavitation bubbles is generated along at least one cavitation bubble path, wherein at least a partial area (42) of an outer cavitation bubble path of an outer edge area (50), as radially viewed, of the volume body (12) to be separated is generated with a higher cavitation bubble density than an inner cavitation bubble path.

Use of a treatment apparatus is disclosed for cut-free transfer of a tissue of a correction area of a human or animal eye from a determined actual state into an ascertained desired state. The treatment apparatus includes a fiber laser device, which includes a fiber oscillator and/or a fiber amplifier. In addition, a method is disclosed for providing control data of a fiber laser device for a correction of the eye tissue as well as to the corresponding apparatuses.

Systems, devices and methods are provided to deliver microporation medical treatments to improve biomechanics, wherein the system includes a laser for generating a beam of laser radiation on a treatment-axis not aligned with a patient's visual-axis, operable for use in subsurface ablative medical treatments to create an array pattern of micropores that improves biomechanics. The array pattern of micropores is at least one of a radial pattern, a spiral pattern, a phyllotactic pattern, or an asymmetric pattern.

The present invention relates to a method for recommending a vision correction surgery, and the method according to one aspect of the present invention comprises: obtaining an examination data of a subject; predicting whether the vision correction surgery is suitable for the subject from the examination data; when the vision correction surgery is suitable for the subject, predicting whether the vision correction surgery using a laser is available for the subject from the examination data; when the vision correction surgery using the laser is available for the subject, calculating corneal shape factor prediction values of the subject after a standard vision correction surgery and a custom vision correction surgery from the examination data; and when the vision correction surgery using the laser is available for the subject, suggesting a vision correction surgery corresponding to the subject from the examination data.

Systems and methods automatically locate optical surfaces of an eye and automatically generate surface models of the optical surfaces. A method includes OCT scanning of an eye. Returning portions of a sample beam are processed to locate a point on the optical surface and first locations on the optical surface within a first radial distance of the point. A first surface model of the optical surface is generated based on the location of the point and the first locations. Returning portions of the sample beam are processed so as to detect second locations on the optical surface beyond the first radial distance and within a second radial distance from the point. A second surface model of the optical surface is generated based on the location of the point on the optical surface and the first and second locations on the optical surface.

Generation of treatment recommendations for topographic-based excimer laser surgical procedures is described that includes generating accurate cylinder compensation and spherical compensation values that are adjusted to compensate for unique characteristics of advanced topographic-based excimer laser surgical systems. Generating treatment recommendations generally includes determining a topographic vector from a topographic corneal map of the eye, determining a posterior astigmatism vector and an anterior astigmatism vector for the eye, and generating an interior astigmatism vector using the topographic vector, the posterior astigmatism vector, the anterior astigmatism vector, and a manifest astigmatism vector. In various embodiments, the cylinder compensation is generated using the interior astigmatism vector and the posterior astigmatism vector, and the spherical compensation is generated using an initial spherical compensation modified by a topographic addback modifier and a cylinder addback modifier.