A minimally invasive ab interno triple surgery for open-angle glaucoma comprises knotting and fixing a suture at the head end of an optical fiber catheter; performing miosis with carbachol, injecting the viscoelastic into the anterior chamber, making a lateral incision at the infratemporal corneal limbus, and placing the optical fiber catheter; cutting the Schlemm's canal on the nasal side of the anterior chamber, inserting an optical fiber into the incision on the Schlemm's canal, and cutting off the suture; injecting the viscoelastic to expand while retreating the microcatheter, and regularly injecting the viscoelastic; making a conjunctival flap on the eye and nose side, performing anterior chamber paracentesis, clamping out the suture using intraocular microforceps, and knotting in the sclera tunnel; and suturing the conjunctival flap using the suture, coating the eyes, and covering the eyes with gauze to finish the surgery.

Glaucoma patients suffer from increased intraocular pressure due to blocked fluid flow from the anterior chamber of the eye. Methods of the invention include inserting a probe into an eye of a subject having glaucoma, adjusting placement of the probe to a position transverse to Schlemm's canal in the eye, and applying a plurality of shots from an excimer laser source while the probe is in the transverse position, thereby treating glaucoma by creating a plurality of perforations in Schlemm's canal and/or the trabecular meshwork. By providing a laser probe at a position transverse to Schlemm's canal, energy from the laser is delivered to a greater amount of surface area than if the laser was arranged in a parallel or perpendicular position to Schlemm's canal, resulting in optimal formation of perforations. The perforations allow for drainage of fluid and increased outflow of aqueous humor in the eye.

Devices and methods of regulating intraocular pressure can include implanting an intraocular shunt into an eye at a desired location within the sclera. Some methods involve creating an opening in the sclera, and positioning a shunt in the anterior chamber of the eye such that the shunt terminates via the opening in the intrascleral space, thereby facilitating fluid flow through both the opening and the intrascleral space.

A method of treating a subject having glaucoma comprises performing excimer laser trabeculostomy (ELT) on a subject having glaucoma and having previously undergone a failed treatment or a treatment that has been rendered ineffective by progression of the disease. In some examples, the failed treatment is a non-surgical treatment comprising administering medicated eye drops. In some examples, the failed treatment is a laser treatment or surgical treatment, such as a trabeculoplasty, iridotomy, iridectomy, trabeculectomy, trabeculotomy, goniotomy, surgical insertion of a shunt or implant, deep sclerectomy, viscocanalostomy, or a combination thereof.

A system (20) comprises a radiation source (48) and a controller (44). The controller is configured to designate multiple target regions (84) on an eye (25) of a patient (22) for irradiation with respective amounts of energy, to cause the radiation source to irradiate at least a first one of the target regions, to identify a change in the eye by processing an image of the eye subsequently to causing the radiation source to irradiate at least the first one of the target regions, and to refrain, in response to identifying the change, from causing the radiation source to irradiate a second one of the target regions, which has not yet been irradiated, with the amount of energy designated for the second one of the target regions. Other embodiments are also described.

A computer-based surgery support system and method for obtaining information of surgical procedures from networked equipment in an operating room, storing the retrieved information in a database, receiving a request for the stored information from a user terminal, and providing the stored information in accordance with the received request. The networked equipment may be configured for use in cataract surgical procedures, such as a phacoemulsification system.

Systems, devices, and methods for treating a glaucomatous eye are provided. An amount of pulsed laser energy is delivered to the pars plana of the eye by a hand-holdable device which comprises a hand-holdable elongate member and a contact member disposed on an end of the elongate member. A contact surface of the contact member is placed in direct contact with the eye so that a reference edge of the contact member aligns with the limbus and a treatment axis defined by the elongate member is angularly offset from the optical axis of the eye. The amount of pulsed laser energy delivered is insufficient to effect therapeutic photocoagulation but is sufficient to increase uveoscleral outflow so as to maintain a reduction from pre-laser treatment intraocular pressure. Amounts of pulsed laser energy will be transmitted to a circumferential series of tissue regions of the eye.

Apparatus for medical treatment includes a laser source, which is configured to output a beam of laser radiation. An optical device is configured to direct the laser radiation to impinge on a limbal area of an eye with optical properties chosen so as to apply a desired treatment to a tissue structure associated with a cornea of the eye within the limbal area.

Devices and methods useable for forming opening in trabecular meshwork of mammalian eyes.

In some embodiments, an ophthalmic laser system may be provided that does not include a traditional laser console. Instead, the treatment device may be configured to house the treatment light source within the device handle. Additionally, in some embodiments, the handheld treatment device may include a user interface, such as dials and buttons, for adjusting various parameters of the therapeutic light. With certain embodiments, the self-contained handheld treatment device may be operated independent of an AC power source. For example, in some embodiments, the handheld treatment device may be battery powered. Additionally, the handheld treatment device may be disposable or may utilize replaceable distal tips in certain embodiments. Certain embodiments may be particularly designed for transscleral cyclophotocoagulation. Also, treatment guides are provided that may be configured to couple with a treatment device to align the device with a target tissue of the eye.