A system for forming a corneal implant includes a cutting apparatus, which includes a laser source that emits a laser and optical elements that direct the laser. The system includes a controller implemented with at least one processor and at least one data storage device. The controller generates a sculpting plan for modifying a first shape of a lenticule formed from corneal tissue and achieving a second shape for the lenticule to produce a corneal implant with a refractive profile to reshape a recipient eye. The sculpting plan is determined from measurements relating to the lenticule having the first shape and information relating to a refractive profile for a corneal implant. The controller controls the cutting apparatus to direct, via the one or more optical elements, the laser from the laser source to sculpt the lenticule according to the sculpting plan to produce the corneal implant with the refractive profile.

A device and a method for irradiating the cornea of an eye, wherein the device includes at least the following elements: a ring body, which has a bearing surface embodied concentrically about the longitudinal axis of the device for the purpose of fastening the device on the eye, an irradiation channel for irradiating the cornea, which is located inside the ring body, a light source, which, in the operationally-ready state of the device, is attached inside the ring body for emitting light in the irradiation channel, wherein the bearing surface for fastening the device is arranged outside the irradiation channel, which has the result that the irradiated area itself is not additionally loaded by bearing surfaces of the device.

Devices and approaches for monitoring time based photo active agent delivery or photo active marker presence in an eye. A monitoring system is provided for measuring the presence of a photo active marker by illuminating the eye so as to excite the photo-active marker and then observing characteristic emission from the photo active marker. Example systems incorporate Scheimpflug optical systems or slit lamp optical systems to observe cross sectional images of an eye to monitor instantaneous distribution, diffusion pattern, and rate of uptake of a photo active agent applied to an eye. Systems and methods further allow for utilizing the monitored distribution of photo active agent in the eye as feedback for a cross-linking system.

A cornea holder assembly for laser surgery of an eye, especially for refractive surgery, such as for keratoplasty. The cornea holder includes an elongated cornea holder base having a longitudinal axis and an upper curved surface along at least 50% of a surface area of the cornea holder base. The curved surface is shaped and sized to hold at least a portion of a cornea in a curved orientation. The cornea holder further includes a cornea holder alignment cover, configured to be placed on top of the cornea holder base.

Devices and methods for the amelioration of ectatic corneal disorders using corneal augmentations derived from corneal tissue are disclosed. The shape of the augmentation is determined using data obtained from mapping of a patient's cornea based on computerized corneal topography and tomography. Factors considered include the maximum keratometry and specific iso-deviation contours. In one embodiment, an augmentation is a corneal inlay, intended for insertion into an intrastromal pocket. In a further embodiment, the augmentation is a corneal onlay, intended to be positioned over a region of the cornea from which the epithelial layer has been removed. The corneal onlay is held in place until the epithelial layer regrows over the augmentation. In a further embodiment, the inlay or onlay augmentation is followed by a post-augmentation, further reshaping of the corneal augmentation. In one embodiment, this further reshaping is photorefractive keratectomy (PRK) surgery.

A device and a method for irradiating the cornea of an eye, wherein the device includes at least the following elements: a ring body, which has a bearing surface embodied concentrically about the longitudinal axis of the device for the purpose of fastening the device on the eye, an irradiation channel for irradiating the cornea, which is located inside the ring body, a light source, which, in the operationally-ready state of the device, is attached inside the ring body for emitting light in the irradiation channel, wherein the bearing surface for fastening the device is arranged outside the irradiation channel, which has the result that the irradiated area itself is not additionally loaded by bearing surfaces of the device.

A cross-linking device and system are disclosed. In various embodiments, a cross-linking device includes a main body including a sidewall, a corneal gripping portion positioned in the interior cavity and defining an anterior chamber and an ocular chamber and defining an aperture that is configured to allow passage of a portion of a cornea to extend into the anterior chamber. In various embodiments, the device includes a multi-purpose fluid port positioned on the sidewall and defining two or more fluid pathways that connect a pair of exterior ports to an anterior chamber port, and an ocular chamber port respectively to allow for fluids to pass into and out of the interior of the device. In various embodiments the device is constructed from elastomer and, in response to a vacuum, the corneal gripping portion is configured to conform to the eye and seal the anterior chamber.

A method of corneal lenslet implantation with a cross-linked cornea is disclosed herein. In one or more embodiments, the method includes the steps of: (i) forming a two-dimensional cut into a cornea of an eye; (ii) creating a three-dimensional pocket in the cornea of the eye in tissue around the two-dimensional cut to gain access to tissue surrounding the three-dimensional pocket; (iii) applying a photosensitizer inside the three-dimensional pocket so the photosensitizer permeates at least a portion of the tissue surrounding the three-dimensional pocket to facilitate cross-linking of the tissue surrounding the three-dimensional pocket; (iv) irradiating the cornea to activate cross-linkers in the portion of the tissue surrounding the three-dimensional pocket, and thereby stiffen the cornea, prevent corneal ectasia of the cornea, and kill cells in the portion of the tissue surrounding the three-dimensional pocket; and (v) inserting a lens implant into the three-dimensional pocket through a small corneal incision.

Ophthalmic treatment systems and methods of using the systems are disclosed. The ophthalmic treatment systems include (a) a light source device; (b) at least one optical treatment head operatively coupled to the light source device, comprising a light source array, and providing at least one treatment light; and (c) a light control device, which (i) provides patterned or discontinuous treatment light projection onto an eye (e.g., the cornea and/or sclera of an eye); or (ii) adjusts intensity of part or all of the light source array, providing adjusted intensity treatment light projection onto an eye (e.g., the cornea and/or sclera of an eye). The at least one treatment light promotes corneal and/or scleral collagen cross-linking.

An ophthalmological device (10) for the treatment of corneal diseases such as keratoconus and glaucoma, comprises a moulding head (12), a suction body (14) and a UV lamp (15). The moulding head (12) has a hollow cylindrical configuration and includes a rigid moulding lens (18) for shaping the cornea of an eye (11) of a patient. The lens is curved and defines a plurality of apertures therein. The suction body (14) has a hollow cylindrical configuration. The lamp (15) is fitted to the suction body. Moulding head (12) and suction body (14) together define a chamber (32) from which air is evacuated so as to induce a partial vacuum within the chamber (32) for attracting the cornea onto the lens (18). A photo-sensitizer is applied to the eye and while the cornea is held against the mould, it is irradiated with UV light by lamp (15) so as to cross-link collagen fibres in the cornea.