The present application relates generally to a method for vision correction using corneal collagen crosslinking (CCXL), in which the physician is able to precisely control the pattern of ultraviolet (UV) energy delivered to the cornea, by means of a programmable masking array placed between the UV source and the cornea. A CCXL LCD masked is used to create various patterns of on and off pixels. The physician is able to control the degree of polarization of the LCD pixels, thereby allowing the physician to create various patterns of UV irradiation and thus, varying levels of CCXL.

An example system for corneal treatment includes an illumination system to generate cross-linking in at least one selected region of a cornea treated with a cross-linking agent by delivering photoactivating light according to one or more photoactivation parameters. The system includes a controller to receive input relating to one or more treatment parameters, which include the one or more photoactivation parameters. The controller is configured to output information for adjusting the one or more treatment parameters by (A) determining from the input, a distribution of cross-links for the at least one selected region of the cornea; (B) determining, from the distribution of cross-links, a shape change for the cornea; and (C) determining, from the shape change for the cornea, a change in vision for the subject. Responsive to the output from the controller, the illumination system is configured to adjust at least one of the one or more photoactivation parameters.

A cross-linking device and system are disclosed. In various embodiments, a cross-linking device includes a main body including a sidewall, a corneal gripping portion positioned in the interior cavity and defining an anterior chamber and an ocular chamber and defining an aperture that is configured to allow passage of a portion of a cornea to extend into the anterior chamber. In various embodiments, the device includes a multi-purpose fluid port positioned on the sidewall and defining two or more fluid pathways that connect a pair of exterior ports to an anterior chamber port, and an ocular chamber port respectively to allow for fluids to pass into and out of the interior of the device. In various embodiments the device is constructed from elastomer and, in response to a vacuum, the corneal gripping portion is configured to conform to the eye and seal the anterior chamber.

A conformable covering comprises an outer portion with rigidity to resist movement on the cornea and an inner portion to contact the cornea and provide an environment for epithelial regeneration. The inner portion of the covering can be configured in many ways so as to conform at least partially to an ablated stromal surface so as to correct vision. The conformable inner portion may have at least some rigidity so as to smooth the epithelium such that the epithelium regenerates rapidly and is guided with the covering so as to form a smooth layer for vision. The inner portion may comprise an amount of rigidity within a range from about 110-4 Pa*m3 to about 510-4 Pa*m3 so as to deflect and conform at least partially to the ablated cornea and smooth an inner portion of the ablation with an amount of pressure when deflected.

The present invention relates to a method of altering the refractive properties of the eye, the method including applying a substance to a cornea of an eye, the substance configured to facilitate cross linking of the cornea, irradiating the cornea so as to activate cross linkers in the cornea, and altering the cornea so as to change the refractive properties of the eye.

The disclosure provides a system that may: receive data associated with multiple locations associated with a cornea of an eye; adjust at least one lens, based at least on diameter information of the data associated with at least one of the multiple locations, to set a diameter of a laser beam; and for each location of the multiple locations: determine if the eye has changed from a first position to a second position; if the eye has not changed from the first position to the second position, adjust, based at least on the location, at least one mirror; if the eye has changed from the first position to the second position, adjust, based at least on the location and based at least on the second position, the at least one mirror; produce the laser beam; and direct the laser beam to the location for a period of time.

Ophthalmic treatment systems and methods of using the systems are disclosed. The ophthalmic treatment systems include (a) a light source device; (b) at least one optical treatment head operatively coupled to the light source device, comprising a light source array, and providing at least one treatment light; and (c) a light control device, which (i) provides patterned or discontinuous treatment light projection onto an eye (e.g., the cornea and/or sclera of an eye); or (ii) adjusts intensity of part or all of the light source array, providing adjusted intensity treatment light projection onto an eye (e.g., the cornea and/or sclera of an eye). The at least one treatment light promotes corneal and/or scleral collagen cross-linking.

Ophthalmic treatment systems and methods of using the systems are disclosed. The ophthalmic treatment systems include (a) a light source device; (b) at least one optical treatment head operatively coupled to the light source device, comprising a light source array, and providing at least one treatment light; and (c) a light control device, which (i) provides patterned or discontinuous treatment light projection onto an eye (e.g., the cornea and/or sclera of an eye); or (ii) adjusts intensity of part or all of the light source array, providing adjusted intensity treatment light projection onto an eye (e.g., the cornea and/or sclera of an eye). The at least one treatment light promotes corneal and/or scleral collagen cross-linking.

The invention relates to treatment apparatus (10) for correcting a refractive error of an eye (12) that includes a laser device (14) for separating corneal tissue by means of laser radiation (16); a control device (18) designed to control the laser device (14) to emit the laser radiation (16) for cutting out and/or ablating a volume (24) out of the surface (26) of the cornea (22) of the eye (12) in dependency on a measured pachymetry of the cornea (22) and the refractive error of the eye (12), whereby the cut-out and/or ablated volume (24) in the surface (20) of the cornea (22) results in a shape of a closed ring, a partial ring, a crescent or a crescent shaped closed ring. A method for controlling such an apparatus for correcting a refractive error of an eye, and to a protective mask for an eye are also provided.

An example system for corneal treatment includes an illumination system to generate cross-linking in at least one selected region of a cornea treated with a cross-linking agent by delivering photoactivating light according to photoactivation parameters. The system includes a controller to receive input relating to treatment parameters, which include the photoactivation parameters. The controller is configured to output information for adjusting the one or more treatment parameters by (A) determining from the input, a distribution of cross-links for at least one selected region of the cornea; and (B) determining, from the distribution of cross-links, a shape change for the cornea. Responsive to the output from the controller, the illumination system is configured to adjust at least one of the one or more photoactivation parameters and determine a shape change according to a biomechanical model, and at least one of a biochemical model or an optical mode.