A sponge including one or more hemostatic agents and one or more binding agents. At least one of the hemostatic agents is a pregelatinized potato starch. The collective percentage by weight of the one or more hemostatic agents is within the range of approximately one eighth to approximately sixteen times as great as the collective percentage by weight of the one or more binding agents.

Fibrin Sealant products are used for topical hemostasis and tissue adherence. They are composed of two main reagents, fibrinogen and thrombin. When mixed in solution fibrinogen is converted to fibrin upon the addition of activated thrombin. Therefore typically these two components are stored separately in a lyophilized or liquid state, and mixed, upon or immediately before, application to a patient. While effective, these products require significant preparation that must take place immediately before application, thus delaying treatment and limiting the use of these haemostatic products to the treatment of mild forms of low pressure and low volume bleeding. Attempts to eliminate this delay and expand the usefulness and effectiveness of these products have resulted in products produced by processes that require the separation of these components and their deposition in distinct layers within the product. The processes described herein permit the mixing of fibrinogen and thrombin during product manufacture, without excessive fibrin formation. The resulting pre-mixed fibrin sealant material can then be stored in either a frozen or dried state, or suspended in a non-aqueous environment. Activation of the material to form therapeutic fibrin sealant is accomplished by permitting the product to thaw (if frozen) or by the addition of water or other aqueous fluid, including blood, or other bodily fluids, if dried or suspended in a non-aqueous environment. The resulting material can be used to make a product in which a pre-mixed form of activatable fibrin sealant is a desired component.

Disclosed are solid and frozen haemostatic materials and dressings consisting essentially of a fibrinogen component and a fibrinogen activator. Also disclosed are methods of treating internal wounded tissue in a mammal by applying one or more of these haemostatic materials and dressings.

Disclosed are solid and frozen haemostatic materials having a rod shape and suitable applicators and plungers for application of such dressings to wounded tissue wherein said dressings consisting essentially of a fibrinogen component and a fibrinogen activator. Also disclosed are methods of treating internal wounded tissue in a mammal by applying one or more of these haemostatic materials and dressings, particularly for the treatment of injured tissue via endoscopic or minimally-invasive surgical techniques.

A method, medicated feminine sanitary products and pharmaceutical compositions for reducing menstrual blood loss in a female are provided. The method includes administering a hemostatic agent on a medicated feminine sanitary product during menstrual bleeding, wherein the hemostatic agent is incorporated in the medicated feminine sanitary product as a pharmaceutically acceptable composition, wherein the hemostatic agent is -amino-caproic acid, wherein the feminine sanitary product includes an amount of -amino-caproic acid ranging from 100 mg to 500 mg.

A method for obtaining a biopolymer hemostatic powder including adding in an reactor (1) a mixture of an organic acid (b), a combination of alcohols (b) (d) and a bioadhesive to obtain a binder solution and a step of incorporating on a base of the lower part of a fluid bed reactor (2) a polysaccharide (a) driven by an air stream injected at controlled temperature and speed; on which fluid and micro particles of the polysaccharide (a) are sprayed from the top of said fluid bed reactor (2) the binding solution and where the polysaccharide (a) is chitosan, the organic acid (b) is acetic acid, the alcohol combination (c) is alcohol and polyalcohol and the bioadhesive is polyvinyl alcohol. The product contains between 55 and 85% w/w of a polysaccharide; between 10 to 40% w/w of an organic acid; up to 17% w/w of a combination of alcohols and up to 3% w/w of a bioadhesive; whose alcohol combination is composed of 95% of an alcohol and 5% of a polyalcohol and the binder fluid is sprayed onto the polymer in an amount of between 50 and 150% p/p.

Methods, materials, articles, assemblies, systems, devices, kits and computer hardware/software for improving medical procedures, including, but not limited to, hemodialysis. Particular beneficial designs and uses of disinfecting patches, scab removal patches, hemostatic patches, healing patches and artificial scabs are included. For example, scab removal patches that avoid tenting, hemostatic patches with needle stabilizing elements, hemostatic patches applying pressure at a skin puncture site and a vessel puncture site, artificial scabs that release antimicrobial agents, etc.

The invention provides a solid foam wound dressing useful for hemorrhage control and wound repair, as well as methods for making such a wound dressing.

Compositions that include a clay such as kaolin dispersed in a liquid such as water may be useful for promoting the clotting of blood. The compositions may be in a liquid, gel, paste, foam, or another form. Uses may include treating a traumatic injury such as in injury caused by a bullet, an explosive, a blade etc., or an injury caused during a medical procedure such as surgery.

The present invention provides a hemostatic composite sponge comprising oxidized cellulose and an essentially gelatin-free bioadhesive material stably associated with said sponge and present in an organized pattern on said sponge.