A hydro-enlarged apertured non-woven web includes a plurality of fibers with a plurality of bond points, a first surface defining a planar top, and a second surface defining a planar bottom. The second surface is separated from the first surface by a first distance defining a loft. A plurality of apertures extending through the non-woven web. The plurality of apertures is formed by spraying a fluid against an unapertured precursor web, causing a plurality of pins disposed on a pinned roller to punch through the unapertured precursor web. The unapertured precursor web has a third surface defining a planar top and a fourth surface defining a planar bottom, where the third surface is separated from the fourth surface by a second distance defining a precursor loft. The loft is greater than the precursor loft by a loft increase within a range of 50-110%.

Disclosed herein are nucleotide analogs, methods of synthesizing nucleotide analogs and methods of treating diseases and/or conditions such as a HBV and/or HDV and/or HIV infection with one or more nucleotide analogs.

Disclosed herein are nucleotide analogs, methods of synthesizing nucleotide analogs and methods of treating diseases and/or conditions such as a HBV and/or HDV and/or HIV infection with one or more nucleotide analogs.

A dressing for treating a tissue site with negative pressure includes a manifold having a first surface and a second surface opposite the first surface. The dressing also includes a first layer adjacent to the first surface and a second layer adjacent to the second surface. The first layer and the second layer each include a polymer film. The dressing also includes a plurality of fluid restrictions in the polymer film adjacent to at least the first surface, and a plurality of bonds between the first layer and the second layer. The plurality of bonds defines separable sections of the manifold.

The present disclosure includes absorbent products having an apertured zone in the surface facing the wearer for enhanced absorbency and BM containment. Some aspects of the products include a chassis including a topsheet defining a plurality of apertures, and a backsheet, an absorbent core disposed between the topsheet and the backsheet, and an acquisition-distribution layer (ADL) disposed between the topsheet and the absorbent core, the ADL including a plurality of external edges that cooperate to define an ADL boundary. In some aspects at least 75% of the plurality of apertures are defined within an apertured region that is disposed vertically above the ADL and is enclosed within the ADL boundary when the chassis is in a flat configuration.

A patterned apertured web is disclosed. The patterned apertured web includes a plurality of land areas in the patterned apertured web and a plurality of apertures defined in the patterned apertured web. At least some land areas of the plurality of land areas surround at least some apertures of the plurality of apertures. The patterned apertured web has an Effective Open Area in the range of about 3% to about 30%, according to the Aperture Test herein. The plurality of apertures include a first set of apertures defining a first shape and a second set of apertures defining a second shape. The first shape is positioned within the second shape.

A patterned apertured web is disclosed. The patterned apertured web includes a plurality of land areas in the patterned apertured web and a plurality of apertures defined in the patterned apertured web. At least some land areas of the plurality of land areas surround at least some apertures of the plurality of apertures. The patterned apertured web has an Effective Open Area in the range of about 3% to about 30%, according to the Aperture Test herein. The plurality of apertures include a first set of apertures defining a first shape and a second set of apertures defining a second shape. The first shape is positioned within the second shape.

An absorbent article can have a topsheet layer, a liquid impermeable layer, and an absorbent core positioned between the topsheet layer and the liquid impermeable layer. The absorbent article can further include an exudate management layer in fluid communication with the topsheet layer. In various embodiments, the exudate management layer can be positioned on a body facing surface of the topsheet layer. In various embodiments, the exudate management layer can be positioned between the topsheet layer and the absorbent core. The exudate management layer has a first component which defines an opening for direct passage of body exudates into the absorbent core. The exudate management layer has a second component which at least partially overlaps the first component of the exudate management layer and further extends in the longitudinal direction of the absorbent article in a direction towards the posterior region of the absorbent article.

A nonwoven fabric. The nonwoven fabric can include a first surface and a second surface and a visually discernible pattern of three-dimensional features on one of the first or second surface. Each of the three-dimensional features can define a microzone comprising a first region and a second region. The first and second regions can have a difference in values for an intensive property. The nonwoven further has a plurality of apertures, wherein at least a portion of the aperture abuts at least one of the first region and the second region of the microzone.

A nonwoven fabric. The nonwoven fabric can include a first surface and a second surface and a visually discernible pattern of three-dimensional features on one of the first or second surface. Each of the three-dimensional features can define a microzone comprising a first region and a second region. The first and second regions can have a difference in values for an intensive property. The nonwoven further has a plurality of apertures, wherein at least a portion of the aperture abuts at least one of the first region and the second region of the microzone.