A process for producing an antibacterial coating composition for implants. The process includes the steps i) reaction of a monomer A which is based on (meth)acrylic acid and contains at least one epoxide with a polyguanidine by reaction of an amino group of the polyguanidine with the epoxide to give a (meth)acrylic acid-polyguanidine macromolecule and ii) polymerization of the (meth)acrylic acid-polyguanidine macromolecule with a monomer B which contains at least one polymerizable double bond and at least one phosphonate group by free-radical polymerization of the (meth)acrylic acid unit and the double bond.

Fired magnesium oxide stabilized zirconia ceramic body having a highly smooth, polished or otherwise equivalent surface has, on at least part of the surface, a metal/metal alloy coating. The fired ceramic body can be a magnesium oxide stabilized tetragonally toughened zirconia. The coating can be from a metal or metal alloy other than by tantalum vapor deposition, and can include a titanium metal or alloy. The coating can be a macro coating, up to less than about 0.015 of an inch in thickness. The coated magnesium oxide stabilized zirconia ceramic can be a tool or an orthopedic implant or component for an orthopedic implant, which can be a load bearing implant or component for a load bearing implant having an articular surface and a nonarticular surface where the metal or metal alloy coating is on at least part of the nonarticular surface. Plasma arc spraying under vacuum may be employed.

A surface coating for a medical instrument includes an interference filter having at least one dielectric layer and at least one metallic layer arranged one above another. At least one of the at least one metallic layer and the at least one dielectric layer is adapted to be structurally altered by action of a corrosive environment on the surface coating such that the surface coating is convertible from a first state to a second state. In the first state, the surface coating has a first spectral reflectivity. In the second state, the surface coating has a second spectral reflectivity that is different from the first spectral reflectivity.

A composition and medical implant made therefrom, the composition including a thick diffusion hardened zone, and preferably further including a ceramic layer. Also provided are orthopedic implants made from the composition, methods of making the composition, and methods of making orthopedic implants from the composition.

The invention relates to bioactive surface coatings deposited on selected substrates. Surface nanostructured film coatings deposited on most metal or nonmetal substrates to provide surfaces can be engineered to promote enhanced tissue/cell adhesion. Attached cells, including osteoblasts, fibroblasts and endothelial cells, retain viability and will readily differentiate and proliferate under appropriate conditions. Fibroblasts and endothelial cells exhibit good attachment and growth on most coated substrates, except on nano surfaced structured silicone.

A surface coating for a medical instrument includes an interference filter having at least one dielectric layer and at least one metallic layer arranged one above another. At least one of the at least one metallic layer and the at least one dielectric layer is adapted to be structurally altered by action of a corrosive environment on the surface coating such that the surface coating is convertible from a first state to a second state. In the first state, the surface coating has a first spectral reflectivity. In the second state, the surface coating has a second spectral reflectivity that is different from the first spectral reflectivity.

A bone implant includes a body having a porous structure and having a size and shape configured for fitting to a bone, preferably in a bone defect. The porous structure is comprised of regularly arranged elementary cells whose interior spaces form interconnected pores, the elementary cells are formed by basic elements arranged in layers, wherein the basic elements are shaped like tetrapods, the tetrapods in each layer being arranged in parallel orientation and being positioned in-layer rotated with respect to tetrapods of an adjacent layer. The layers with rotated and non-rotated tetrapods are alternatingly arranged. Thereby a porous structure can be achieved which features improved mechanical characteristics, leading to improved biocompatibility.

A vertebral body spacer of the present invention is used by being inserted between a vertebral body and a vertebral body (intervertebral space). The vertebral body spacer has a block body constituted of titanium or a titanium alloy as a main component thereof, and provided with a pair of contact surfaces to be made contact with the vertebral body and the vertebral body. The block body includes dense sheets having a dense part on at least a surface thereof and porous sheets having a porous part on at least a surface thereof. The porous part has a larger porosity than a porosity of the dense part. Each of the porous sheets is sandwiched between the pair of dense sheets. According to the present invention, it is possible to maintain an appropriate size between the vertebral bodies (intervertebral space).

The invention relates to bioactive surface coatings deposited on selected substrates. Surface nanostructured film coatings deposited on most metal or nonmetal substrates to provide surfaces can be engineered to promote enhanced tissue/cell adhesion. Attached cells, including osteoblasts, fibroblasts and endothelial cells, retain viability and will readily differentiate and proliferate under appropriate conditions. Fibroblasts and endothelial cells exhibit good attachment and growth on most coated substrates, except on nano surfaced structured silicone.

A process for producing an antibacterial coating composition for implants. The process includes the steps i) reaction of a monomer A which is based on (meth)acrylic acid and contains at least one epoxide with a polyguanidine by reaction of an amino group of the polyguanidine with the epoxide to give a (meth)acrylic acid-polyguanidine macromolecule and ii) polymerization of the (meth)acrylic acid-polyguanidine macromolecule with a monomer B which contains at least one polymerizable double bond and at least one phosphonate group by free-radical polymerization of the (meth)acrylic acid unit and the double bond.