Compositions including a surface or film comprising nanofibers, nanotubes or microwells comprising a bioactive agent for elution to the surrounding tissue upon placement of the composition in a subject are disclosed The compositions are useful in medical implants and methods of treating a patient in need of an implant, including orthopedic implants, dental implants, cardiovascular implants, neurological implants, neurovascular implants, gastrointestinal implants, muscular implants, and ocular implants.

An implant system for total shoulder arthroplasties, hemi shoulder arthroplasties, and “reverse” total shoulder arthroplasties including a humeral stem having an enlarged head portion with interfaces adapted to removably receive various modular interchangeable components, such as articulating liners, spacers, and adapter inserts. The humeral stem functions as a universal platform that may be used in either conventional or “reverse” total shoulder arthroplasties, as well as hemi shoulder arthroplasties, and may remain implanted in place during a revision in which the implant system is converted between the foregoing configurations, for example.

An orthopaedic knee prosthesis includes a femoral component which exhibits enhanced articular features, minimizes removal of healthy bone stock from the distal femur, and minimizes the impact of the prosthesis on adjacent soft tissues of the knee.

The modular stem component may include a shaft portion, a head, and a sleeve. The shaft portion is configured for receipt within the intramedullary canal of a bone and the head is configured to receive another component of a modular prosthetic system, such as a femoral neck, thereon. In one exemplary embodiment, the head extends radially around at least a portion of the stem and includes a rib defining a flange extending therefrom. The sleeve, which is formed as an independent part of the modular stem component and is made at least partially of a highly porous biomaterial, includes opposing ends and has a bore extending therethrough. The bore is configured to facilitate sliding receipt of the sleeve on the head.

The present invention disclosed a method of producing a three-dimensional porous tissue in-growth structure. The method includes the steps of depositing a first layer of metal powder and scanning the first layer of metal powder with a laser beam to form a portion of a plurality of predetermined unit cells. Depositing at least one additional layer of metal powder onto a previous layer and repeating the step of scanning a laser beam for at least one of the additional layers in order to continuing forming the predetermined unit cells. The method further includes continuing the depositing and scanning steps to form a medical implant.

An orthopaedic knee prosthesis includes a femoral component which exhibits enhanced articular features, minimizes removal of healthy bone stock from the distal femur, and minimizes the impact of the prosthesis on adjacent soft tissues of the knee.

A bone implant includes a body having a porous structure and having a size and shape configured for fitting to a bone, preferably in a bone defect. The porous structure is comprised of regularly arranged elementary cells whose interior spaces form interconnected pores, the elementary cells are formed by basic elements arranged in layers, wherein the basic elements are shaped like tetrapods, the tetrapods in each layer being arranged in parallel orientation and being positioned in-layer rotated with respect to tetrapods of an adjacent layer. The layers with rotated and non-rotated tetrapods are alternatingly arranged. Thereby a porous structure can be achieved which features improved mechanical characteristics, leading to improved biocompatibility.

The present invention disclosed a method of producing a three-dimensional porous tissue in-growth structure. The method includes the steps of depositing a first layer of metal powder and scanning the first layer of metal powder with a laser beam to form a portion of a plurality of predetermined unit cells. Depositing at least one additional layer of metal powder onto a previous layer and repeating the step of scanning a laser beam for at least one of the additional layers in order to continuing forming the predetermined unit cells. The method further includes continuing the depositing and scanning steps to form a medical implant.

A method of making an implant having a porous portion is disclosed. The method comprises the following steps: obtaining an artificial foam containing porous portion; scanning the artificial foam to obtain a digital porous model; editing the digital porous model; assembling the digital porous model to form a digital porous block; editing the digital porous block to obtain a digital implant model; forming the implant by printing the digital implant model through a 3D printer. An implant and a method of calculating porosity a porosity of a porous material are also disclosed.

The disclosure includes a porous implantable structure, that includes substantially regularly arranged elementary cells, wherein the elementary cells include interior spaces that form a plurality of interconnected pores, the elementary cells include basic elements arranged in layers, wherein the basic elements are configured to form a non-polygonal shape of each of the plurality of interconnected pores, wherein each layer is offset with respect to an adjacent layer.