A closed path vial fill system includes a bulk product vial, a peristaltic pump operated by a stepper motor, a dispensing manifold assembly to which may be coupled at least one final product vial, an optional quality check station, and an optional waste collection system. A concentration, activity, and volume (CAV) sensor may be incorporated into the system to receive a radiopharmaceutical product directly from a synthesizing unit. A control system may be integrated into the system to provide automated control of various aspects of the radiopharmaceutical dispensing process. The system is used to aseptically dispense finished radiopharmaceuticals into receiving vessels, such as a Quality Control vial, a sterility vial, and/or final product vials, while providing users an efficient means for removing and discarding contaminated disposable components.

A vial adaptor comprises first and second housings coupled to each other, a sheath enclosing the first and second housings, and a spike disposed in the first and second housings. The first and second housings form a first chamber therein. The sheath and the first and second housings form therebetween a second chamber in air communication with the first chamber. The second housing is slidable relative to the first housing to cause the spike piercing through a front stopper to establish air and fluid communication with a vial attached to the vial adaptor, meanwhile to vary the volume of the first chamber and press the air into the second chamber. Upon a fluid being drawn from the vial, the air in the first and second chambers enters the vial to compensate the pressure reduction caused by the fluid drawn out to prevent fluid spillage or aerosolizing from the vial.

A primary packaging for storage and/or administration of medical or pharmaceutical compounds includes a container that has a predetermined filling volume for receiving a medical or pharmaceutical compound. The container is permanently closed at a first end and has an integrally formed, circumferential flange portion at an open second end. The container has a cylindrical barrel that extends between the first end and the flange portion such that the barrel has an inner diameter and outer diameter corresponding to that of a standardized syringe for a nominal volume of the standardized syringe corresponding to the predetermined filling volume. Furthermore, a cross-sectional shape of the flange portion corresponds to the cross-sectional shape of a flange of a standardized vial. The primary packaging also includes a closure element that is adapted to fit tightly on the flange portion and into the barrel for sealing the open second end of the container.

A medical delivery device (1; 10) comprises a rod element (3; 30), a dosage member (6; 60) and a lock mechanism. The rod element (3; 30) has a stem (31; 310) with a longitudinal axis (38; 380), a distal end and a proximal end. The dosage member (6; 60) comprises a delivery orifice (62; 620) and a chamber body (61; 610) with a distal end, a proximal end and a hollow interior. The stem (31; 310) of the rod element (3; 30) extends into the interior of the chamber body (61; 610) of the dosage member (6; 60) and the delivery orifice (62; 620) is arranged adjacent to the proximal end of the stem (31; 310) of the rod element (3; 30). In a dosing status of the medical delivery device (1; 10), the rod element (3; 30) is movable along its longitudinal axis (38; 380) relative to the delivery orifice (62; 620) of the dosage member (6; 60), such that a dosage chamber (611; 6110) is formed in the interior of the chamber body (61; 610) of the dosage member (6; 60) between the stem (31; 310) of the rod element (3; 30) and the delivery orifice (62; 620) which dosage chamber (611; 6110) increases when the rod element (3; 30) moves away from the delivery orifice (62; 620). The lock mechanism (530; 2410) is adapted for changing the medical delivery device (1; 10) from a lock status to the dosing status, wherein, in the lock status of the medical delivery device (1; 10), moving the rod element (3; 30) along its longitudinal axis (38; 380) relative to the delivery orifice (62; 620) of the dosage member (6; 60) is prevented.

Medical delivery device (10) comprises a rod element (30) and a dosage member (60). The rod element (30) has a stem (310) with a longitudinal axis (380), a first thread arrangement (3320, 3330), a distal end and a proximal end. The dosage member (60) comprises a delivery orifice (620) and a chamber body (610) with a distal end, a proximal end and a hollow interior. The stem (310) of the rod element (30) extends into the interior of the chamber body (610) of the dosage member (60) and the delivery orifice (620) is arranged adjacent to the proximal end of the stem (310) of the rod element (30). In a dosing status of the medical delivery device (10), the rod element (30) is movable along its longitudinal axis (380) relative to the delivery orifice (620) of the dosage member (60) by the first thread arrangement (3320, 3330) of the stem (310) of the rod element (30) and a second thread arrangement (650) travelling along each other. Thereby, a dosage chamber (6110) is formed in the interior of the chamber body (610) of the dosage member (60) between the stem (310) of the rod element (30) and the delivery orifice (620) which dosage chamber (6110) increases when the rod element (30) moves away from the delivery orifice (620). The dosage member (60) comprises the second thread arrangement (650). Thereby, in the dosing status of the medical delivery device (10), the first thread arrangement (3320, 3330) of the rod element (30) engages the second thread arrangement (650) of the dosage member (60).

A medical delivery device (1; 10) comprises a rod element (3; 30), a dosage member (6; 60) and a lock mechanism. The rod element (3; 30) has a stem (31; 310) with a longitudinal axis (38; 380), a distal end and a proximal end. The dosage member (6; 60) comprises a delivery orifice (62; 620) and a chamber body (61; 610) with a distal end, a proximal end and a hollow interior. The stem (31; 310) of the rod element (3; 30) extends into the interior of the chamber body (61; 610) of the dosage member (6; 60) and the delivery orifice (62; 620) is arranged adjacent to the proximal end of the stem (31; 310) of the rod element (3; 30). In a dosing status of the medical delivery device (1; 10), the rod element (3; 30) is movable along its longitudinal axis (38; 380) relative to the delivery orifice (62; 620) of the dosage member (6; 60), such that a dosage chamber (611; 6110) is formed in the interior of the chamber body (61; 610) of the dosage member (6; 60) between the stem (31; 310) of the rod element (3; 30) and the delivery orifice (62; 620) which dosage chamber (611; 6110) increases when the rod element (3; 30) moves away from the delivery orifice (62; 620). The lock mechanism (530; 2410) is adapted for changing the medical delivery device (1; 10) from a lock status to the dosing status, wherein, in the lock status of the medical delivery device (1; 10), moving the rod element (3; 30) along its longitudinal axis (38; 380) relative to the delivery orifice (62; 620) of the dosage member (6; 60) is prevented.

A medical delivery device (1) comprises a rod element (3), a dial shell (4), a delivery orifice (62) and a switching mechanism (7, 36). The rod element (3) has a stem (31) with a longitudinal axis (38), a first thread arrangement (35, 36), a proximal end and a distal end. The dial shell (4) has a second thread arrangement (411). The delivery orifice (62) is arranged adjacent to the proximal end of the stem (31) of the rod element (3). The switching mechanism (7, 36) is arranged for changing the medical delivery device (1) from a dosing status to a delivery status. In the dosing status of the medical delivery device (1), the first thread arrangement (35, 36) of the rod element (3) and the second thread arrangement (411) of the dial shell (4) engage, the rod element (3) is movable along the longitudinal axis (38) of its stem (31) relative to the delivery orifice (62) by rotating the dial shell (4) around the stem (31) of the rod element (3) causing the first thread arrangement (35, 36) of the rod element (3) and the second thread arrangement (411) of the dial shell (4) to travel along each other, wherein a dosage chamber (611) is formed between the rod element (3) and the delivery orifice (62) when the rod element (3) moves away from the delivery orifice (62), and moving the rod element (3) along the longitudinal axis (38) of its stem (31) by applying an axial force to the rod element (3) is prevented. In the delivery status of the medical delivery device (1), the rod element (3) is movable along the longitudinal axis (38) of its stem (31) relative to the delivery orifice (62) by applying an axial force to the rod element (3), and moving the rod element (3) along the longitudinal axis (38) of its stem (31) by rotating the dial shell (4) around the stem (31) of the rod element (3) is prevented. The medical delivery device (1) according to the invention allows on one hand to precisely dose a liquid, for example from a container (9), and on the other hand for a convenient self-administration of the liquid after being dosed.

A dosing device includes a rod element and a shell. The rod element has a stem with a longitudinal axis and a first thread arrangement. The shell has a second thread arrangement. The first thread arrangement of the rod element or the second thread arrangement of the shell includes a thread. The first thread arrangement of the rod element and the second thread arrangement of the shell engage. The rod element is movable along the longitudinal axis of its stem by rotating the shell and the rod element relative to each other causing the first thread arrangement of the rod element and the second thread arrangement of the shell to travel along each other. A dosage chamber is formed by moving the rod element along the longitudinal axis of its stem. The volume of the dosage chamber is varied by moving the rod element along the longitudinal axis of its stem. An inclination angle (?, ?) of the thread varies along the thread. The dosing device according to the invention can allow for a precise and convenient dosing of a liquid out of a container. In particular, it can allow for efficiently dosing a comparably small volume out of a comparably large container.

In one aspect, a method is provided herein of preparing a drug delivery device, the drug delivery device having a body with at least one fluid duct being open along a first face of the body, the at least one fluid duct for conveying drug from at least one reservoir to a needle configured for injection into a patient, the method including: providing a barrier across the first face of the body to at least cover the at least one fluid duct, wherein the barrier is ultraviolet transmissive; and, exposing the first face of the body to ultraviolet radiation so as to allow the ultraviolet radiation to pass through the barrier and decontaminate the at least one fluid duct.

An apparatus that includes a container portion and a coupler portion. The container and coupler are, in one embodiment, mated via an adapter that includes a one-way valve. The coupler includes a second one-way valve. In use, a fluid source, such as a vial, is connected to the coupler. An air source, such as a syringe is also connected to the coupler. Air from the syringe is introduced to the vial via the second one-way valve. The second one-way valve prevents fluid from the vial from being drawn into the syringe. Introduction of air from the syringe into the vial forces fluid from the vial into the container via the first one-way valve. The first one-way valve prevents the fluid from escaping the container.